Lymphovascular Space Invasion for Endometrial Cancer: Undertreatment and Overtreatment Risks: A Survey of the Spanish Gynecologic Oncology Group
OBJECTIVEThe purpose of this study is to asses the impact of lymphovascular space invasion (LVSI) present in early-stage endometrial cancer, regarding its therapeutic management and prognosis knowledge, based on a survey among Spanish oncologic gynecologist. METHODS/MATERIALSBetween October and Nove...
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| Veröffentlicht in: | International journal of gynecological cancer 2017-07, Vol.27 (6), p.1191-1199 |
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| container_title | International journal of gynecological cancer |
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| creator | Gorostidi Pulgar, Mikel Diaz de la Noval, Begoña Gil-Ibañez, Blanca Lago Leal, Victor Jaunarena Marin, Ibon Padilla Iserte, Pablo |
| description | OBJECTIVEThe purpose of this study is to asses the impact of lymphovascular space invasion (LVSI) present in early-stage endometrial cancer, regarding its therapeutic management and prognosis knowledge, based on a survey among Spanish oncologic gynecologist.
METHODS/MATERIALSBetween October and November 2014, the Young Spanish Onco-gynecologist Group carried out a survey to perform a cross-sectional study about the management of LVSI. All active members in the oncology field of the Spanish Society of Gynecology and Obstetrics were invited to participate in the survey.
RESULTSMost respondents consider LVSI a bad prognosis factor for endometrial cancer (66%) and also consider that it should be included in the International Federation of Gynecology and Obstetrics classification (56%). Seventy-five percent of all gynecologists did not modify their surgical treatment. Regarding follow-up, 38% of the respondents do not change their surveillance, 28% modify it, and 31% reported any change only with additional factors. Forty-seven percent of respondents advise systemic treatment with chemotherapy.Data were dichotomized between less than or equal to 20 versus greater than 20 years of OB-GYN specialist and less than or equal to 5 versus greater than 5 years of main dedication to gynecology oncology, but it was not possible to show any significant differences among the groups. The response rate (34 individuals) was too low to expect any significant differences.
CONCLUSIONSResults suggest that LVSI remains a controversial issue in the management of patients with endometrial cancer. Acquiring a deeper knowledge and uniform criteria could avoid the risk of undertreatment and overtreatment in this group of patients with early-stage endometrial cancer. The identification of vascular pseudoinvasion is recommended, although the clinical and prognostic implications still need to be determined. |
| doi_str_mv | 10.1097/IGC.0000000000001022 |
| format | Article |
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METHODS/MATERIALSBetween October and November 2014, the Young Spanish Onco-gynecologist Group carried out a survey to perform a cross-sectional study about the management of LVSI. All active members in the oncology field of the Spanish Society of Gynecology and Obstetrics were invited to participate in the survey.
RESULTSMost respondents consider LVSI a bad prognosis factor for endometrial cancer (66%) and also consider that it should be included in the International Federation of Gynecology and Obstetrics classification (56%). Seventy-five percent of all gynecologists did not modify their surgical treatment. Regarding follow-up, 38% of the respondents do not change their surveillance, 28% modify it, and 31% reported any change only with additional factors. Forty-seven percent of respondents advise systemic treatment with chemotherapy.Data were dichotomized between less than or equal to 20 versus greater than 20 years of OB-GYN specialist and less than or equal to 5 versus greater than 5 years of main dedication to gynecology oncology, but it was not possible to show any significant differences among the groups. The response rate (34 individuals) was too low to expect any significant differences.
CONCLUSIONSResults suggest that LVSI remains a controversial issue in the management of patients with endometrial cancer. Acquiring a deeper knowledge and uniform criteria could avoid the risk of undertreatment and overtreatment in this group of patients with early-stage endometrial cancer. The identification of vascular pseudoinvasion is recommended, although the clinical and prognostic implications still need to be determined.</description><identifier>ISSN: 1048-891X</identifier><identifier>EISSN: 1525-1438</identifier><identifier>DOI: 10.1097/IGC.0000000000001022</identifier><identifier>PMID: 28557833</identifier><language>eng</language><publisher>United States: by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology</publisher><subject>Adult ; Cross-Sectional Studies ; Endometrial Neoplasms - drug therapy ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - surgery ; Endometrial Neoplasms - therapy ; Female ; Humans ; Lymphatic Metastasis ; Lymphatic System - pathology ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Practice Patterns, Physicians ; Prognosis ; Spain ; Surveys and Questionnaires</subject><ispartof>International journal of gynecological cancer, 2017-07, Vol.27 (6), p.1191-1199</ispartof><rights>2017 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28557833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorostidi Pulgar, Mikel</creatorcontrib><creatorcontrib>Diaz de la Noval, Begoña</creatorcontrib><creatorcontrib>Gil-Ibañez, Blanca</creatorcontrib><creatorcontrib>Lago Leal, Victor</creatorcontrib><creatorcontrib>Jaunarena Marin, Ibon</creatorcontrib><creatorcontrib>Padilla Iserte, Pablo</creatorcontrib><title>Lymphovascular Space Invasion for Endometrial Cancer: Undertreatment and Overtreatment Risks: A Survey of the Spanish Gynecologic Oncology Group</title><title>International journal of gynecological cancer</title><addtitle>Int J Gynecol Cancer</addtitle><description>OBJECTIVEThe purpose of this study is to asses the impact of lymphovascular space invasion (LVSI) present in early-stage endometrial cancer, regarding its therapeutic management and prognosis knowledge, based on a survey among Spanish oncologic gynecologist.
METHODS/MATERIALSBetween October and November 2014, the Young Spanish Onco-gynecologist Group carried out a survey to perform a cross-sectional study about the management of LVSI. All active members in the oncology field of the Spanish Society of Gynecology and Obstetrics were invited to participate in the survey.
RESULTSMost respondents consider LVSI a bad prognosis factor for endometrial cancer (66%) and also consider that it should be included in the International Federation of Gynecology and Obstetrics classification (56%). Seventy-five percent of all gynecologists did not modify their surgical treatment. Regarding follow-up, 38% of the respondents do not change their surveillance, 28% modify it, and 31% reported any change only with additional factors. Forty-seven percent of respondents advise systemic treatment with chemotherapy.Data were dichotomized between less than or equal to 20 versus greater than 20 years of OB-GYN specialist and less than or equal to 5 versus greater than 5 years of main dedication to gynecology oncology, but it was not possible to show any significant differences among the groups. The response rate (34 individuals) was too low to expect any significant differences.
CONCLUSIONSResults suggest that LVSI remains a controversial issue in the management of patients with endometrial cancer. Acquiring a deeper knowledge and uniform criteria could avoid the risk of undertreatment and overtreatment in this group of patients with early-stage endometrial cancer. The identification of vascular pseudoinvasion is recommended, although the clinical and prognostic implications still need to be determined.</description><subject>Adult</subject><subject>Cross-Sectional Studies</subject><subject>Endometrial Neoplasms - drug therapy</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - surgery</subject><subject>Endometrial Neoplasms - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic System - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Practice Patterns, Physicians</subject><subject>Prognosis</subject><subject>Spain</subject><subject>Surveys and Questionnaires</subject><issn>1048-891X</issn><issn>1525-1438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1q3DAUhUVpaX7aNyhFy26cXkm2JWcXhnQ6MDDQNNCdkOXr2o0suZI9wW_RR67zUwi9m3s4fJzFOYR8YHDBoJKfd9vNBbw4Bpy_Iqes4EXGcqFerxpylamK_TghZyn9WqGKQ_WWnHBVFFIJcUr-7Jdh7MLRJDs7E-nNaCzSnV-NPnjahkivfRMGnGJvHN0YbzFe0lvfYJwimmlAP1HjG3o4vnS-9ekuXdIrejPHIy40tHTq8CHe96mj28WjDS787C09-Ee10G0M8_iOvGmNS_j--Z-T2y_X3zdfs_1hu9tc7bORl8AzwbARJRdFUeW1wkaWlWllqyRwkLmwrWGyAcmwtqqubQulQllKyxXUlgOIc_LpKXeM4feMadJDnyw6ZzyGOWlWQc6hXHta0Y_P6FwP2Ogx9oOJi_7X4gqoJ-A-uAljunPzPUbdoXFTpxnoh8H0Opj-fzDxF6_kiDs</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Gorostidi Pulgar, Mikel</creator><creator>Diaz de la Noval, Begoña</creator><creator>Gil-Ibañez, Blanca</creator><creator>Lago Leal, Victor</creator><creator>Jaunarena Marin, Ibon</creator><creator>Padilla Iserte, Pablo</creator><general>by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Lymphovascular Space Invasion for Endometrial Cancer: Undertreatment and Overtreatment Risks: A Survey of the Spanish Gynecologic Oncology Group</title><author>Gorostidi Pulgar, Mikel ; Diaz de la Noval, Begoña ; Gil-Ibañez, Blanca ; Lago Leal, Victor ; Jaunarena Marin, Ibon ; Padilla Iserte, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2602-31ed36235594b8ed769af7f87020743cfa17d071ebc8bbcf068e767c280bc2003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Cross-Sectional Studies</topic><topic>Endometrial Neoplasms - drug therapy</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - surgery</topic><topic>Endometrial Neoplasms - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic System - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Practice Patterns, Physicians</topic><topic>Prognosis</topic><topic>Spain</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorostidi Pulgar, Mikel</creatorcontrib><creatorcontrib>Diaz de la Noval, Begoña</creatorcontrib><creatorcontrib>Gil-Ibañez, Blanca</creatorcontrib><creatorcontrib>Lago Leal, Victor</creatorcontrib><creatorcontrib>Jaunarena Marin, Ibon</creatorcontrib><creatorcontrib>Padilla Iserte, Pablo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecological cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorostidi Pulgar, Mikel</au><au>Diaz de la Noval, Begoña</au><au>Gil-Ibañez, Blanca</au><au>Lago Leal, Victor</au><au>Jaunarena Marin, Ibon</au><au>Padilla Iserte, Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphovascular Space Invasion for Endometrial Cancer: Undertreatment and Overtreatment Risks: A Survey of the Spanish Gynecologic Oncology Group</atitle><jtitle>International journal of gynecological cancer</jtitle><addtitle>Int J Gynecol Cancer</addtitle><date>2017-07</date><risdate>2017</risdate><volume>27</volume><issue>6</issue><spage>1191</spage><epage>1199</epage><pages>1191-1199</pages><issn>1048-891X</issn><eissn>1525-1438</eissn><abstract>OBJECTIVEThe purpose of this study is to asses the impact of lymphovascular space invasion (LVSI) present in early-stage endometrial cancer, regarding its therapeutic management and prognosis knowledge, based on a survey among Spanish oncologic gynecologist.
METHODS/MATERIALSBetween October and November 2014, the Young Spanish Onco-gynecologist Group carried out a survey to perform a cross-sectional study about the management of LVSI. All active members in the oncology field of the Spanish Society of Gynecology and Obstetrics were invited to participate in the survey.
RESULTSMost respondents consider LVSI a bad prognosis factor for endometrial cancer (66%) and also consider that it should be included in the International Federation of Gynecology and Obstetrics classification (56%). Seventy-five percent of all gynecologists did not modify their surgical treatment. Regarding follow-up, 38% of the respondents do not change their surveillance, 28% modify it, and 31% reported any change only with additional factors. Forty-seven percent of respondents advise systemic treatment with chemotherapy.Data were dichotomized between less than or equal to 20 versus greater than 20 years of OB-GYN specialist and less than or equal to 5 versus greater than 5 years of main dedication to gynecology oncology, but it was not possible to show any significant differences among the groups. The response rate (34 individuals) was too low to expect any significant differences.
CONCLUSIONSResults suggest that LVSI remains a controversial issue in the management of patients with endometrial cancer. Acquiring a deeper knowledge and uniform criteria could avoid the risk of undertreatment and overtreatment in this group of patients with early-stage endometrial cancer. The identification of vascular pseudoinvasion is recommended, although the clinical and prognostic implications still need to be determined.</abstract><cop>United States</cop><pub>by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology</pub><pmid>28557833</pmid><doi>10.1097/IGC.0000000000001022</doi><tpages>9</tpages></addata></record> |
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| ispartof | International journal of gynecological cancer, 2017-07, Vol.27 (6), p.1191-1199 |
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| subjects | Adult Cross-Sectional Studies Endometrial Neoplasms - drug therapy Endometrial Neoplasms - pathology Endometrial Neoplasms - surgery Endometrial Neoplasms - therapy Female Humans Lymphatic Metastasis Lymphatic System - pathology Middle Aged Neoplasm Invasiveness Neoplasm Staging Practice Patterns, Physicians Prognosis Spain Surveys and Questionnaires |
| title | Lymphovascular Space Invasion for Endometrial Cancer: Undertreatment and Overtreatment Risks: A Survey of the Spanish Gynecologic Oncology Group |
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