Novel Mutation (T273R) in Thyroid Hormone Receptor β Gene Provides Further Insight into Cryptic Negative Regulation by Thyroid Hormone

Production of thyroid hormone is precisely regulated in a negative feed-back mechanism that depends critically on thyroid hormone receptor β (TRβ). This mechanism decreases production of thyrotropin- releasing hormone (TRH) and thyrotropin (TSH) in the hypothalamus and pituitary gland in response to...

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Veröffentlicht in:	Folia biologica 2017, Vol.63 (2), p.60-66
Hauptverfasser:	Kaššák, F, Hána, V, Saudek, V, Kostrouchová, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Humans Hypothalamus - metabolism Male Mutation Thyroid Hormone Receptors beta - genetics Thyroid Hormones - metabolism Thyrotropin - metabolism Thyrotropin-Releasing Hormone - metabolism
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