Total Synthesis of Isohericerin, Isohericenone, and Erinacerin A: Development of a Copper-Catalyzed Methylboronation of Terminal Alkynes

Efficient and concise approaches for the synthesis of three bioactive natural products, isohericerin, isohericenone, and erinacerin A, are described in this paper. The key reactions employed include a Mannich reaction with commercially available hydroxy­benzoate and subsequent one-pot lactamization...

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Veröffentlicht in:	Journal of organic chemistry 2017-06, Vol.82 (12), p.6349-6357
Hauptverfasser:	Mun, Bohyun, Kim, Sangyong, Yoon, Hongju, Kim, Ki Hyun, Lee, Yunmi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Boron Compounds - chemical synthesis Boron Compounds - chemistry Catalysis Copper - chemistry Heterocyclic Compounds, 3-Ring - chemical synthesis Heterocyclic Compounds, 3-Ring - chemistry Indole Alkaloids - chemical synthesis Indole Alkaloids - chemistry Molecular Structure
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