Formation of lamellar micelle-like oligomers and membrane disruption revealed by the study of short peptide hIAPP18-27

Prefibrillar amyloid aggregates of proteins are known as cytotoxic species and a common pathogenic factor for many degenerative diseases. The mechanism underlying the formation and cytotoxicity of prefibrillar aggregates is believed to be independent of the actual nature of the amyloid protein. In t...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2016-11, Vol.18 (43), p.29847-29857
Hauptverfasser:	Wei, Ying, Lu, Jun, Lu, Tong, Meng, Feihong, Xu, Jia, Wang, Li, Li, Yang, Wang, Liping, Li, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Formations Lamellar structure Membranes Oligomers Peptides Proteins Toxicity
Online-Zugang:	Volltext
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