Phthalimide conjugation as a strategy for in vivo target protein degradation

The development of effective pharmacological inhibitors of multidomain scaffold proteins, notably transcription factors, is a particularly challenging problem. In part, this is because many small-molecule antagonists disrupt the activity of only one domain in the target protein. We devised a chemica...

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Veröffentlicht in:	Science 2015-06, Vol.348 (6241), p.1376-1381
Hauptverfasser:	Winter, Georg E., Buckley, Dennis L., Paulk, Joshiawa, Roberts, Justin M., Souza, Amanda, Dhe-Paganon, Sirano, Bradner, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Degradation Enzymes Leukemia Leukemias Molecular biology Phthalimides Progressions Proteins Rodents Strategy
Online-Zugang:	Volltext
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