Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
Scope Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry‐enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; l...
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| Veröffentlicht in: | Molecular nutrition & food research 2017-09, Vol.61 (9), p.1700019-n/a |
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| creator | Mello, Vanessa DF Lankinen, Maria A Lindström, Jaana Puupponen‐Pimiä, Riitta Laaksonen, David E Pihlajamäki, Jussi Lehtonen, Marko Uusitupa, Matti Tuomilehto, Jaakko Kolehmainen, Marjukka Törrönen, Riitta Hanhineva, Kati |
| description | Scope
Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry‐enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism.
Methods and results
Hippuric acid was measured with LC‐QTOF‐MS metabolite profiling analysis from fasting serum samples at baseline and after an 8‐week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5‐fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p |
| doi_str_mv | 10.1002/mnfr.201700019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1903944280</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1903944280</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3407-87767416a356158700f00a4b0b47539e8a3fb2f2ac6358e8974d8d36d9c0fbf83</originalsourceid><addsrcrecordid>eNqFkUtvFDEQhEcIRELgyhH5GA67-DWvI4pYQAogIeA68njauw2eB25Povmz_BY82WWvnGxLVV91u7LspeBbwbl80w8ubCUXJedc1I-yS1EItdFCqcfnu8wvsmdEPzlXQmr1NLuQVZ4XeVldZn92hiIOe0YQ5p4dcJrmgJYZix1DYuDhzkTomHERAmvRtxDCwq5_GGtxwOTplxDR-5leMzsONPdTxHFgZkgmotFi8hO7x3hg2E9hvIMehshGx9wpe-9nOxKwlAWeHpyYQB6HNJYN8MBLjwkCpQRmYhp0f2AB6dfK6VbfOK2ouEzAJOvQtJBin2dPnPEEL07nVfZ99-7bzYfN7Zf3H2_e3m6s0rzcVGVZlFoURuWFyKv0mY5zo1ve6jJXNVRGuVY6aWyh8gqqutRd1amiqy13ravUVXZ95Kb9fs9AsemRLHhvBhhnakTNVa21rHiSbo9SG0aiAK6ZAvYmLI3gzdpps3banDtNhlcn9tz20J3l_0pMAn0U3KOH5T-45tPn3VdZ61L9BRs7svI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1903944280</pqid></control><display><type>article</type><title>Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Mello, Vanessa DF ; Lankinen, Maria A ; Lindström, Jaana ; Puupponen‐Pimiä, Riitta ; Laaksonen, David E ; Pihlajamäki, Jussi ; Lehtonen, Marko ; Uusitupa, Matti ; Tuomilehto, Jaakko ; Kolehmainen, Marjukka ; Törrönen, Riitta ; Hanhineva, Kati</creator><creatorcontrib>Mello, Vanessa DF ; Lankinen, Maria A ; Lindström, Jaana ; Puupponen‐Pimiä, Riitta ; Laaksonen, David E ; Pihlajamäki, Jussi ; Lehtonen, Marko ; Uusitupa, Matti ; Tuomilehto, Jaakko ; Kolehmainen, Marjukka ; Törrönen, Riitta ; Hanhineva, Kati</creatorcontrib><description>Scope
Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry‐enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism.
Methods and results
Hippuric acid was measured with LC‐QTOF‐MS metabolite profiling analysis from fasting serum samples at baseline and after an 8‐week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5‐fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198).
Conclusion
Fasting serum hippuric acid is increased after consumption of anthocyanin‐rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β‐cell function.
Bilberries are rich dietary source of phenolic compounds, in particular anthocyanins. Our study demonstrates how high consumption of bilberries resulted in increased plasma levels of hippuric acid, a compound resulting from metabolism of colonic microbiota. Increased plasma hippuric acid was associated with beneficial changes in glucose and insulin metabolism, and may thus contribute to the beneficial health effects related to bilberry consumption.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201700019</identifier><identifier>PMID: 28556578</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Bilberry ; Blood Glucose - analysis ; Diabetes Mellitus, Type 2 - prevention & control ; Fasting - blood ; Female ; Glucose metabolism ; Hippurates - blood ; Hippuric acid ; Humans ; Insulin - metabolism ; Insulin Secretion ; LC‐MS ; Male ; Middle Aged ; Vaccinium myrtillus</subject><ispartof>Molecular nutrition & food research, 2017-09, Vol.61 (9), p.1700019-n/a</ispartof><rights>2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3407-87767416a356158700f00a4b0b47539e8a3fb2f2ac6358e8974d8d36d9c0fbf83</citedby><cites>FETCH-LOGICAL-c3407-87767416a356158700f00a4b0b47539e8a3fb2f2ac6358e8974d8d36d9c0fbf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201700019$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201700019$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28556578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mello, Vanessa DF</creatorcontrib><creatorcontrib>Lankinen, Maria A</creatorcontrib><creatorcontrib>Lindström, Jaana</creatorcontrib><creatorcontrib>Puupponen‐Pimiä, Riitta</creatorcontrib><creatorcontrib>Laaksonen, David E</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Lehtonen, Marko</creatorcontrib><creatorcontrib>Uusitupa, Matti</creatorcontrib><creatorcontrib>Tuomilehto, Jaakko</creatorcontrib><creatorcontrib>Kolehmainen, Marjukka</creatorcontrib><creatorcontrib>Törrönen, Riitta</creatorcontrib><creatorcontrib>Hanhineva, Kati</creatorcontrib><title>Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry‐enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism.
Methods and results
Hippuric acid was measured with LC‐QTOF‐MS metabolite profiling analysis from fasting serum samples at baseline and after an 8‐week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5‐fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198).
Conclusion
Fasting serum hippuric acid is increased after consumption of anthocyanin‐rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β‐cell function.
Bilberries are rich dietary source of phenolic compounds, in particular anthocyanins. Our study demonstrates how high consumption of bilberries resulted in increased plasma levels of hippuric acid, a compound resulting from metabolism of colonic microbiota. Increased plasma hippuric acid was associated with beneficial changes in glucose and insulin metabolism, and may thus contribute to the beneficial health effects related to bilberry consumption.</description><subject>Adult</subject><subject>Bilberry</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Mellitus, Type 2 - prevention & control</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucose metabolism</subject><subject>Hippurates - blood</subject><subject>Hippuric acid</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>LC‐MS</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Vaccinium myrtillus</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvFDEQhEcIRELgyhH5GA67-DWvI4pYQAogIeA68njauw2eB25Povmz_BY82WWvnGxLVV91u7LspeBbwbl80w8ubCUXJedc1I-yS1EItdFCqcfnu8wvsmdEPzlXQmr1NLuQVZ4XeVldZn92hiIOe0YQ5p4dcJrmgJYZix1DYuDhzkTomHERAmvRtxDCwq5_GGtxwOTplxDR-5leMzsONPdTxHFgZkgmotFi8hO7x3hg2E9hvIMehshGx9wpe-9nOxKwlAWeHpyYQB6HNJYN8MBLjwkCpQRmYhp0f2AB6dfK6VbfOK2ouEzAJOvQtJBin2dPnPEEL07nVfZ99-7bzYfN7Zf3H2_e3m6s0rzcVGVZlFoURuWFyKv0mY5zo1ve6jJXNVRGuVY6aWyh8gqqutRd1amiqy13ravUVXZ95Kb9fs9AsemRLHhvBhhnakTNVa21rHiSbo9SG0aiAK6ZAvYmLI3gzdpps3banDtNhlcn9tz20J3l_0pMAn0U3KOH5T-45tPn3VdZ61L9BRs7svI</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Mello, Vanessa DF</creator><creator>Lankinen, Maria A</creator><creator>Lindström, Jaana</creator><creator>Puupponen‐Pimiä, Riitta</creator><creator>Laaksonen, David E</creator><creator>Pihlajamäki, Jussi</creator><creator>Lehtonen, Marko</creator><creator>Uusitupa, Matti</creator><creator>Tuomilehto, Jaakko</creator><creator>Kolehmainen, Marjukka</creator><creator>Törrönen, Riitta</creator><creator>Hanhineva, Kati</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes</title><author>Mello, Vanessa DF ; Lankinen, Maria A ; Lindström, Jaana ; Puupponen‐Pimiä, Riitta ; Laaksonen, David E ; Pihlajamäki, Jussi ; Lehtonen, Marko ; Uusitupa, Matti ; Tuomilehto, Jaakko ; Kolehmainen, Marjukka ; Törrönen, Riitta ; Hanhineva, Kati</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3407-87767416a356158700f00a4b0b47539e8a3fb2f2ac6358e8974d8d36d9c0fbf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Bilberry</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Mellitus, Type 2 - prevention & control</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Glucose metabolism</topic><topic>Hippurates - blood</topic><topic>Hippuric acid</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>LC‐MS</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Vaccinium myrtillus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mello, Vanessa DF</creatorcontrib><creatorcontrib>Lankinen, Maria A</creatorcontrib><creatorcontrib>Lindström, Jaana</creatorcontrib><creatorcontrib>Puupponen‐Pimiä, Riitta</creatorcontrib><creatorcontrib>Laaksonen, David E</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Lehtonen, Marko</creatorcontrib><creatorcontrib>Uusitupa, Matti</creatorcontrib><creatorcontrib>Tuomilehto, Jaakko</creatorcontrib><creatorcontrib>Kolehmainen, Marjukka</creatorcontrib><creatorcontrib>Törrönen, Riitta</creatorcontrib><creatorcontrib>Hanhineva, Kati</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mello, Vanessa DF</au><au>Lankinen, Maria A</au><au>Lindström, Jaana</au><au>Puupponen‐Pimiä, Riitta</au><au>Laaksonen, David E</au><au>Pihlajamäki, Jussi</au><au>Lehtonen, Marko</au><au>Uusitupa, Matti</au><au>Tuomilehto, Jaakko</au><au>Kolehmainen, Marjukka</au><au>Törrönen, Riitta</au><au>Hanhineva, Kati</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2017-09</date><risdate>2017</risdate><volume>61</volume><issue>9</issue><spage>1700019</spage><epage>n/a</epage><pages>1700019-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope
Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry‐enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism.
Methods and results
Hippuric acid was measured with LC‐QTOF‐MS metabolite profiling analysis from fasting serum samples at baseline and after an 8‐week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5‐fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198).
Conclusion
Fasting serum hippuric acid is increased after consumption of anthocyanin‐rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β‐cell function.
Bilberries are rich dietary source of phenolic compounds, in particular anthocyanins. Our study demonstrates how high consumption of bilberries resulted in increased plasma levels of hippuric acid, a compound resulting from metabolism of colonic microbiota. Increased plasma hippuric acid was associated with beneficial changes in glucose and insulin metabolism, and may thus contribute to the beneficial health effects related to bilberry consumption.</abstract><cop>Germany</cop><pmid>28556578</pmid><doi>10.1002/mnfr.201700019</doi><tpages>8</tpages></addata></record> |
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| ispartof | Molecular nutrition & food research, 2017-09, Vol.61 (9), p.1700019-n/a |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Bilberry Blood Glucose - analysis Diabetes Mellitus, Type 2 - prevention & control Fasting - blood Female Glucose metabolism Hippurates - blood Hippuric acid Humans Insulin - metabolism Insulin Secretion LC‐MS Male Middle Aged Vaccinium myrtillus |
| title | Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes |
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