Anti-inflammatory effects and corresponding mechanisms of cirsimaritin extracted from Cirsium japonicum var. maackii Maxim

[Display omitted] In this study, we investigated the anti-inflammatory effects and mechanisms of cirsimaritin isolated from an ethanol extract of the aerial parts of Cirsium japonicum var. maackii Maxim. using RAW264.7 cells. The extract and its flavonoid cirsimaritin inhibited nitric oxide (NO) pro...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2017-07, Vol.27 (14), p.3076-3080
Hauptverfasser:	Shin, Myoung-Sook, Park, Jun Yeon, Lee, Jaemin, Yoo, Hye Hyun, Hahm, Dae-Hyun, Lee, Sang Cheon, Lee, Sanghyun, Hwang, Gwi Seo, Jung, Kiwon, Kang, Ki Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Cirsimaritin Cirsium - chemistry Cirsium - metabolism Cirsium japonicum Flavones - chemistry Flavones - isolation & purification Flavones - pharmacology Inflammation Interleukin-6 - metabolism Lipopolysaccharides - toxicity Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice NF-KappaB Inhibitor alpha - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Phosphorylation - drug effects Plant Components, Aerial - chemistry Plant Components, Aerial - metabolism Plant Extracts - chemistry Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-fos - metabolism RAW 264.7 Cells Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Tumor Necrosis Factor-alpha - metabolism
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