Anaplastic Ependymoma With Ganglionic Differentiation: Report of a Rare Case and Implications in Diagnosis
Ependymomas are glial neoplasms with rare cases exhibiting neuronal differentiation. We describe a case of spinal anaplastic ependymoma with ganglionic differentiation in a 28-year-old woman. The ganglionic component was labeled by synaptophysin, whereas the rest of the tumor showed features of an a...
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| Veröffentlicht in: | International journal of surgical pathology 2017-10, Vol.25 (7), p.644-647 |
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| container_title | International journal of surgical pathology |
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| creator | Rao, Shilpa Ravindra, Niveditha Sadashiva, Nishanth Indira Devi, Bhagavatula Santosh, Vani |
| description | Ependymomas are glial neoplasms with rare cases exhibiting neuronal differentiation. We describe a case of spinal anaplastic ependymoma with ganglionic differentiation in a 28-year-old woman. The ganglionic component was labeled by synaptophysin, whereas the rest of the tumor showed features of an anaplastic ependymoma. Stem cell marker MELK was noted to stain both the neoplastic ependymal and ganglionic components, possibly suggesting a stem cell/progenitor origin for the tumor with subsequent divergent differentiation. |
| doi_str_mv | 10.1177/1066896917710716 |
| format | Article |
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We describe a case of spinal anaplastic ependymoma with ganglionic differentiation in a 28-year-old woman. The ganglionic component was labeled by synaptophysin, whereas the rest of the tumor showed features of an anaplastic ependymoma. Stem cell marker MELK was noted to stain both the neoplastic ependymal and ganglionic components, possibly suggesting a stem cell/progenitor origin for the tumor with subsequent divergent differentiation.</description><subject>Adult</subject><subject>Cell Differentiation</subject><subject>Ependymoma - diagnosis</subject><subject>Ependymoma - pathology</subject><subject>Ependymoma - surgery</subject><subject>Female</subject><subject>Ganglia, Spinal - cytology</subject><subject>Ganglia, Spinal - pathology</subject><subject>Ganglia, Spinal - surgery</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Neoplasm Grading</subject><subject>Protein-Serine-Threonine Kinases - analysis</subject><subject>Proto-Oncogene Proteins B-raf - analysis</subject><subject>Spinal cancer</subject><subject>Spinal Cord Neoplasms - diagnosis</subject><subject>Spinal Cord Neoplasms - pathology</subject><subject>Spinal Cord Neoplasms - surgery</subject><subject>Stem cells</subject><subject>Thoracic Vertebrae</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUlrHDEQhYWJiZfk7lMQ5JJL21K1Fss3M17BYDAJOTY1ammioVtqSz0H_3vLGTsBg09V1PveK6Ei5IizY861PuFMqVOjTO0501ztkH1uBGtAKPmp9lVuXvQ9clDKmjEGCvhnsgenUgpo1T5Zn0ecBixzsPRycrF_GtOI9HeY_9BrjKshpFili-C9yy7OAec6OaMPbkp5pslTpA-YHV1gcRRjT2_HaQj2L1ZoiNWKq5hKKF_IrsehuK-v9ZD8urr8ubhp7u6vbxfnd41tlZwbtEJZhSCBeQEAilunllp7sNYb5xT2veIClBLScIZMa5BLy_kShPfWtIfkxzZ3yulx48rcjaFYNwwYXdqUjhvWGgFG64p-f4eu0ybH-roOWiYrKBVUim0pm1Mp2fluymHE_NRx1r3coXt_h2r59hq8WY6u_2d4-_gKNFug4Mr93_ph4DOhXI7S</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Rao, Shilpa</creator><creator>Ravindra, Niveditha</creator><creator>Sadashiva, Nishanth</creator><creator>Indira Devi, Bhagavatula</creator><creator>Santosh, Vani</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Anaplastic Ependymoma With Ganglionic Differentiation: Report of a Rare Case and Implications in Diagnosis</title><author>Rao, Shilpa ; 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| ispartof | International journal of surgical pathology, 2017-10, Vol.25 (7), p.644-647 |
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| subjects | Adult Cell Differentiation Ependymoma - diagnosis Ependymoma - pathology Ependymoma - surgery Female Ganglia, Spinal - cytology Ganglia, Spinal - pathology Ganglia, Spinal - surgery Humans Magnetic Resonance Imaging Neoplasm Grading Protein-Serine-Threonine Kinases - analysis Proto-Oncogene Proteins B-raf - analysis Spinal cancer Spinal Cord Neoplasms - diagnosis Spinal Cord Neoplasms - pathology Spinal Cord Neoplasms - surgery Stem cells Thoracic Vertebrae |
| title | Anaplastic Ependymoma With Ganglionic Differentiation: Report of a Rare Case and Implications in Diagnosis |
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