Microglia-glioblastoma interactions: New role for Wnt signaling
Glioblastoma, the most aggressive and fatal type of brain tumor, is capable of interacting with brain immune cells such as microglia, which contributes to the growth of these tumors. Various molecules, including growth factors and cytokines, have been identified as regulators of microglia-glioblasto...
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| Veröffentlicht in: | Biochimica et biophysica acta. Reviews on cancer 2017-08, Vol.1868 (1), p.333-340 |
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| container_title | Biochimica et biophysica acta. Reviews on cancer |
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| creator | Matias, D. Predes, D. Niemeyer Filho, P. Lopes, M.C. Abreu, J.G. Lima, F.R.S. Moura Neto, V. |
| description | Glioblastoma, the most aggressive and fatal type of brain tumor, is capable of interacting with brain immune cells such as microglia, which contributes to the growth of these tumors. Various molecules, including growth factors and cytokines, have been identified as regulators of microglia-glioblastoma interaction. Recent studies suggest that the Wnt family of lipoglycoproteins plays an important role, not only in biological events during development, but also in cancer progression, and can be part of microglia recruitment to glioblastoma as well as of tumor growth and invasion. Here, we discuss recent interesting findings that support a role for Wnt signaling pathways in the microglia-glioblastoma crosstalk. |
| doi_str_mv | 10.1016/j.bbcan.2017.05.007 |
| format | Article |
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Here, we discuss recent interesting findings that support a role for Wnt signaling pathways in the microglia-glioblastoma crosstalk.</description><subject>Animals</subject><subject>Brain macrophages</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Cytokines - metabolism</subject><subject>Glioblastoma</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma - pathology</subject><subject>Gliomas</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Microglia</subject><subject>Microglia - metabolism</subject><subject>Microglia - pathology</subject><subject>Wnt pathway</subject><subject>Wnt Signaling Pathway - physiology</subject><issn>0304-419X</issn><issn>1879-2561</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotlY_gSB79LLrpNkku4KIFP9B1Yuit5Ck05Ky3dRkq_jtTW316GUGhvfm8X6EHFMoKFBxNi-MsbothkBlAbwAkDukTytZ50Mu6C7pA4MyL2n91iMHMc4BKGdM7JPesOK8FEL2yeWDs8HPGqfzNLxpdOz8Qmeu7TBo2znfxvPsET-z4BvMpj5kr22XRTdrdePa2SHZm-om4tF2D8jLzfXz6C4fP93ej67GuWW87nJeTiopQNIKpSmN1GB4ZWtthEZuK0SOQIdaSsoANRM4LUta2XQFXhmJbEBON3-Xwb-vMHZq4aLFptEt-lVUtAZWl6mXSFK2kaZiMQacqmVwCx2-FAW1Jqfm6oecWpNTwFUil1wn24CVWeDkz_OLKgkuNgJMNT8cBhWtw9bixAW0nZp492_AN4naf7g</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Matias, D.</creator><creator>Predes, D.</creator><creator>Niemeyer Filho, P.</creator><creator>Lopes, M.C.</creator><creator>Abreu, J.G.</creator><creator>Lima, F.R.S.</creator><creator>Moura Neto, V.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Microglia-glioblastoma interactions: New role for Wnt signaling</title><author>Matias, D. ; Predes, D. ; Niemeyer Filho, P. ; Lopes, M.C. ; Abreu, J.G. ; Lima, F.R.S. ; Moura Neto, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-54d8760718e7b4b7a0b58c9ab6ae5c8ee5e012a77130ea36ef4418c5e0058b7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Brain macrophages</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Cytokines - metabolism</topic><topic>Glioblastoma</topic><topic>Glioblastoma - metabolism</topic><topic>Glioblastoma - pathology</topic><topic>Gliomas</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Microglia</topic><topic>Microglia - metabolism</topic><topic>Microglia - pathology</topic><topic>Wnt pathway</topic><topic>Wnt Signaling Pathway - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matias, D.</creatorcontrib><creatorcontrib>Predes, D.</creatorcontrib><creatorcontrib>Niemeyer Filho, P.</creatorcontrib><creatorcontrib>Lopes, M.C.</creatorcontrib><creatorcontrib>Abreu, J.G.</creatorcontrib><creatorcontrib>Lima, F.R.S.</creatorcontrib><creatorcontrib>Moura Neto, V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimica et biophysica acta. 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| identifier | ISSN: 0304-419X |
| ispartof | Biochimica et biophysica acta. Reviews on cancer, 2017-08, Vol.1868 (1), p.333-340 |
| issn | 0304-419X 1879-2561 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain macrophages Brain Neoplasms - metabolism Brain Neoplasms - pathology Cytokines - metabolism Glioblastoma Glioblastoma - metabolism Glioblastoma - pathology Gliomas Humans Intercellular Signaling Peptides and Proteins - metabolism Microglia Microglia - metabolism Microglia - pathology Wnt pathway Wnt Signaling Pathway - physiology |
| title | Microglia-glioblastoma interactions: New role for Wnt signaling |
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