Long non-coding RNA MALAT1 promotes proliferation and suppresses apoptosis of glioma cells through derepressing Rap1B by sponging miR-101

Long non-coding RNAs (lncRNAs) have been recently shown to be dysregulated and closely related to several cancers. Here, we aimed to elucidate the function and the possible molecular mechanisms of lncRNA Metastasis-associated lung Adenocarcinoma transcript-1 (MALAT1) in human glioma. Quantitative re...

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Veröffentlicht in:	Journal of neuro-oncology 2017-08, Vol.134 (1), p.19-28
Hauptverfasser:	Li, Zhenjiang, Xu, Chenyang, Ding, Bingqian, Gao, Ming, Wei, Xinting, Ji, Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Apoptosis Apoptosis - genetics Apoptosis - physiology Brain tumors Cell Count Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cell Proliferation - physiology Cholecystokinin Flow cytometry Glioma Glioma - pathology Glioma cells Humans Laboratory Investigation Lung cancer Medicine Medicine & Public Health Metastases MicroRNAs - genetics MicroRNAs - metabolism Molecular modelling Mutation - genetics Neurology Non-coding RNA Oncology Polymerase chain reaction rap GTP-Binding Proteins - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Time Factors Transcription Transfection Up-Regulation - genetics Up-Regulation - physiology
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