Impact of Small Molecules on β-Catenin and E-Cadherin Expression in HPV16-positive and -negative Squamous Cell Carcinomas

The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib a...

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Veröffentlicht in:	Anticancer research 2017-06, Vol.37 (6), p.2845-2852
Hauptverfasser:	Kramer, Benedikt, Hock, Clemens, Schultz, Johannes David, Lammert, Anne, Kuhlin, Beatrice, Birk, Richard, Hörmann, Karl, Aderhold, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Antineoplastic Agents - pharmacology beta Catenin - metabolism Cadherins - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - virology Cell Line, Tumor Dasatinib - pharmacology Erlotinib Hydrochloride - pharmacology Gefitinib Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - virology Human papillomavirus 16 Humans Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Quinazolines - pharmacology
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