Preoperative CA-125 Values as a Predictive Factor for the Postoperative Outcome in Primary Serous Ovarian Cancer
The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node...
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| Veröffentlicht in: | Anticancer research 2017-06, Vol.37 (6), p.3157-3161 |
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| creator | Muallem, Mustafa Zelal Parashkevova, Asya Almuheimid, Jumana Richter, Rolf Diab, Yasser Braicu, Elena Ioana Sehouli, Jalid |
| description | The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node involvement, diffuse peritoneal carcinomatosis, grading and staging.
A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values.
The median preoperative CA-125 value in high-grade serous POC patients was 636 U/ml (204- 2312 U/ml) compared to 284 U/ml (148.5-1,378 U/ml) in low-grade serous POC patients (p=0.016). For the survival analyses both the cut-off values 252 and 475 U/ml, with highest sum from sensitivity (79.1% and 65.9%, respectively) and specificity (41.9% and 55.1%, respectively), were used to compare the relationship between preoperative CA-125 levels and (CTR), progression-free (PFS) and overall survival (OS). There was no significant difference between PFS and OS in three different groups of patients (preoperative CA-125 levels 475 U/ml).
Preoperative CA-125 is a poor, but statistically significant predictive factor for CTR after PCS. Preoperative CA-125 can predict neither the progression-free nor overall survival for POC patients. |
| doi_str_mv | 10.21873/anticanres.11674 |
| format | Article |
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A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values.
The median preoperative CA-125 value in high-grade serous POC patients was 636 U/ml (204- 2312 U/ml) compared to 284 U/ml (148.5-1,378 U/ml) in low-grade serous POC patients (p=0.016). For the survival analyses both the cut-off values 252 and 475 U/ml, with highest sum from sensitivity (79.1% and 65.9%, respectively) and specificity (41.9% and 55.1%, respectively), were used to compare the relationship between preoperative CA-125 levels and (CTR), progression-free (PFS) and overall survival (OS). There was no significant difference between PFS and OS in three different groups of patients (preoperative CA-125 levels <252 U/ml, CA 125 levels between 252-475 U/ml and >475 U/ml).
Preoperative CA-125 is a poor, but statistically significant predictive factor for CTR after PCS. Preoperative CA-125 can predict neither the progression-free nor overall survival for POC patients.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.11674</identifier><identifier>PMID: 28551658</identifier><language>eng</language><publisher>Greece</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; CA-125 Antigen - blood ; Cytoreduction Surgical Procedures ; Databases, Factual ; Disease-Free Survival ; Female ; Germany ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Membrane Proteins - blood ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Neoplasms, Cystic, Mucinous, and Serous - blood ; Neoplasms, Cystic, Mucinous, and Serous - mortality ; Neoplasms, Cystic, Mucinous, and Serous - secondary ; Neoplasms, Cystic, Mucinous, and Serous - surgery ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; Young Adult</subject><ispartof>Anticancer research, 2017-06, Vol.37 (6), p.3157-3161</ispartof><rights>Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-b617e531b4d42e9f387d450e72550b8922e1ec7646afe40c2bdeb5f73bdb8bfa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28551658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muallem, Mustafa Zelal</creatorcontrib><creatorcontrib>Parashkevova, Asya</creatorcontrib><creatorcontrib>Almuheimid, Jumana</creatorcontrib><creatorcontrib>Richter, Rolf</creatorcontrib><creatorcontrib>Diab, Yasser</creatorcontrib><creatorcontrib>Braicu, Elena Ioana</creatorcontrib><creatorcontrib>Sehouli, Jalid</creatorcontrib><title>Preoperative CA-125 Values as a Predictive Factor for the Postoperative Outcome in Primary Serous Ovarian Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node involvement, diffuse peritoneal carcinomatosis, grading and staging.
A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values.
The median preoperative CA-125 value in high-grade serous POC patients was 636 U/ml (204- 2312 U/ml) compared to 284 U/ml (148.5-1,378 U/ml) in low-grade serous POC patients (p=0.016). For the survival analyses both the cut-off values 252 and 475 U/ml, with highest sum from sensitivity (79.1% and 65.9%, respectively) and specificity (41.9% and 55.1%, respectively), were used to compare the relationship between preoperative CA-125 levels and (CTR), progression-free (PFS) and overall survival (OS). There was no significant difference between PFS and OS in three different groups of patients (preoperative CA-125 levels <252 U/ml, CA 125 levels between 252-475 U/ml and >475 U/ml).
Preoperative CA-125 is a poor, but statistically significant predictive factor for CTR after PCS. Preoperative CA-125 can predict neither the progression-free nor overall survival for POC patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>CA-125 Antigen - blood</subject><subject>Cytoreduction Surgical Procedures</subject><subject>Databases, Factual</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Germany</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis</subject><subject>Membrane Proteins - blood</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Cystic, Mucinous, and Serous - blood</subject><subject>Neoplasms, Cystic, Mucinous, and Serous - mortality</subject><subject>Neoplasms, Cystic, Mucinous, and Serous - secondary</subject><subject>Neoplasms, Cystic, Mucinous, and Serous - surgery</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUMtKAzEUDaLYWv0AN5Klm6l5Z2ZZilWh0IKP7ZBk7uDIvEwyBf_eoa0W7uUuzoN7DkK3lMwZTTV_MG2snGk9hDmlSoszNKU6o4mWnJyjKWGSJJoQOUFXIXwRolSW8ks0YamUVMl0ivqth64Hb2K1A7xcJJRJ_GHqAQI24-ARLyq3R1fGxc7jctz4CXjbhXiSbobougZw1Y6SqjH-B7-C74aANzvjK9PipWkd-Gt0UZo6wM3xztD76vFt-ZysN08vy8U6cVyImFhFNUhOrSgEg6zkqS6EJKCZlMSmGWNAwWkllClBEMdsAVaWmtvCprY0fIbuD769777HNDFvquCgrk0L41c5zQgXXGeKjlR6oDrfheChzPtDgpySfF90fio63xc9au6O9oNtoPhX_DXLfwFDSHz0</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Muallem, Mustafa Zelal</creator><creator>Parashkevova, Asya</creator><creator>Almuheimid, Jumana</creator><creator>Richter, Rolf</creator><creator>Diab, Yasser</creator><creator>Braicu, Elena Ioana</creator><creator>Sehouli, Jalid</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Preoperative CA-125 Values as a Predictive Factor for the Postoperative Outcome in Primary Serous Ovarian Cancer</title><author>Muallem, Mustafa Zelal ; Parashkevova, Asya ; Almuheimid, Jumana ; Richter, Rolf ; Diab, Yasser ; Braicu, Elena Ioana ; Sehouli, Jalid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-b617e531b4d42e9f387d450e72550b8922e1ec7646afe40c2bdeb5f73bdb8bfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>CA-125 Antigen - blood</topic><topic>Cytoreduction Surgical Procedures</topic><topic>Databases, Factual</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Germany</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis</topic><topic>Membrane Proteins - blood</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Cystic, Mucinous, and Serous - blood</topic><topic>Neoplasms, Cystic, Mucinous, and Serous - mortality</topic><topic>Neoplasms, Cystic, Mucinous, and Serous - secondary</topic><topic>Neoplasms, Cystic, Mucinous, and Serous - surgery</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muallem, Mustafa Zelal</creatorcontrib><creatorcontrib>Parashkevova, Asya</creatorcontrib><creatorcontrib>Almuheimid, Jumana</creatorcontrib><creatorcontrib>Richter, Rolf</creatorcontrib><creatorcontrib>Diab, Yasser</creatorcontrib><creatorcontrib>Braicu, Elena Ioana</creatorcontrib><creatorcontrib>Sehouli, Jalid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muallem, Mustafa Zelal</au><au>Parashkevova, Asya</au><au>Almuheimid, Jumana</au><au>Richter, Rolf</au><au>Diab, Yasser</au><au>Braicu, Elena Ioana</au><au>Sehouli, Jalid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative CA-125 Values as a Predictive Factor for the Postoperative Outcome in Primary Serous Ovarian Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>37</volume><issue>6</issue><spage>3157</spage><epage>3161</epage><pages>3157-3161</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node involvement, diffuse peritoneal carcinomatosis, grading and staging.
A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values.
The median preoperative CA-125 value in high-grade serous POC patients was 636 U/ml (204- 2312 U/ml) compared to 284 U/ml (148.5-1,378 U/ml) in low-grade serous POC patients (p=0.016). For the survival analyses both the cut-off values 252 and 475 U/ml, with highest sum from sensitivity (79.1% and 65.9%, respectively) and specificity (41.9% and 55.1%, respectively), were used to compare the relationship between preoperative CA-125 levels and (CTR), progression-free (PFS) and overall survival (OS). There was no significant difference between PFS and OS in three different groups of patients (preoperative CA-125 levels <252 U/ml, CA 125 levels between 252-475 U/ml and >475 U/ml).
Preoperative CA-125 is a poor, but statistically significant predictive factor for CTR after PCS. Preoperative CA-125 can predict neither the progression-free nor overall survival for POC patients.</abstract><cop>Greece</cop><pmid>28551658</pmid><doi>10.21873/anticanres.11674</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over CA-125 Antigen - blood Cytoreduction Surgical Procedures Databases, Factual Disease-Free Survival Female Germany Humans Kaplan-Meier Estimate Lymphatic Metastasis Membrane Proteins - blood Middle Aged Neoplasm Grading Neoplasm Staging Neoplasms, Cystic, Mucinous, and Serous - blood Neoplasms, Cystic, Mucinous, and Serous - mortality Neoplasms, Cystic, Mucinous, and Serous - secondary Neoplasms, Cystic, Mucinous, and Serous - surgery Ovarian Neoplasms - blood Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Predictive Value of Tests Retrospective Studies Risk Factors Time Factors Treatment Outcome Young Adult |
| title | Preoperative CA-125 Values as a Predictive Factor for the Postoperative Outcome in Primary Serous Ovarian Cancer |
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