Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo

UNC-51-like kinase 1 (ULK1) is well-known to initiate autophagy, and the downregulation of ULK1 has been found in most breast cancer tissues. Thus, the activation of ULK1-modulated autophagy could be a promising strategy for breast cancer therapy. In this study, we found that ULK1 was remarkably dow...

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Veröffentlicht in:	Chemical science (Cambridge) 2017-04, Vol.8 (4), p.2687-2701
Hauptverfasser:	Zhang, Lan, Fu, Leilei, Zhang, Shouyue, Zhang, Jin, Zhao, Yuqian, Zheng, Yaxin, He, Gu, Yang, Shengyong, Ouyang, Liang, Liu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Breast Cancer Cell death Chemistry Kinases Screening Synthesis (chemistry) Therapy
Online-Zugang:	Volltext
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