Social Relationships and Inflammatory Markers in the MIDUS Cohort: The Role of Age and Gender Differences
Objective: To better understand age and gender differences in associations of social relationships with chronic inflammation. Method: Using a sample of middle-aged and older adults (N = 963) from the Midlife Development in the United States (MIDUS) biomarker project, we examined interactions of age...
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| Veröffentlicht in: | Journal of aging and health 2018-07, Vol.30 (6), p.904-923 |
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| container_title | Journal of aging and health |
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| creator | Elliot, Ari J. Heffner, Kathi L. Mooney, Christopher J. Moynihan, Jan A. Chapman, Benjamin P. |
| description | Objective: To better understand age and gender differences in associations of social relationships with chronic inflammation. Method: Using a sample of middle-aged and older adults (N = 963) from the Midlife Development in the United States (MIDUS) biomarker project, we examined interactions of age and gender with structural and functional social network measures in predicting interleukin-6 (IL-6) and C-reactive protein (CRP). Results: Significant interactions involving age and gender showed that social support was associated with lower IL-6 in older women, whereas perceived positive relationships and social integration were related to lower IL-6 in both men and women of advanced age. Functional measures were associated with higher CRP in both men and women after adjustment for health conditions and behaviors, with some further variation by age. Discussion: Greater social support may be related to lower IL-6 in older women. Further research is needed to understand observed associations of social support with higher CRP. |
| doi_str_mv | 10.1177/0898264317698551 |
| format | Article |
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Method: Using a sample of middle-aged and older adults (N = 963) from the Midlife Development in the United States (MIDUS) biomarker project, we examined interactions of age and gender with structural and functional social network measures in predicting interleukin-6 (IL-6) and C-reactive protein (CRP). Results: Significant interactions involving age and gender showed that social support was associated with lower IL-6 in older women, whereas perceived positive relationships and social integration were related to lower IL-6 in both men and women of advanced age. Functional measures were associated with higher CRP in both men and women after adjustment for health conditions and behaviors, with some further variation by age. Discussion: Greater social support may be related to lower IL-6 in older women. 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Further research is needed to understand observed associations of social support with higher CRP.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Female</subject><subject>Gender differences</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sex Factors</subject><subject>Social Support</subject><subject>United States - epidemiology</subject><subject>Women</subject><issn>0898-2643</issn><issn>1552-6887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUlPwzAQhS0EomW5c0KWuHAJeIljm1tVtkqtkFo4R44zaVOSuNjpgX9PSgtIlTiNNPO9N6N5CF1QckOplLdEacWSmFOZaCUEPUB9KgSLEqXkIepvxtFm3kMnISwJIYwSeox6rIO5oryPypmzpanwFCrTlq4Ji3IVsGlyPGqKytS1aZ3_xBPj38EHXDa4XQCejO7fZnjoFs63d_i160xdBdgVeDCHb_UTNDl4fF8WBXhoLIQzdFSYKsD5rp6it8eH1-FzNH55Gg0H48jyRLSRopJmhChgmmvQkmVWCxlLxnOWx1bEJMsSZgUITWOrWecvMi6TLKGgGbP8FF1vfVfefawhtGldBgtVZRpw65BSTXjMpVBJh17toUu39k13XcqIUJyrmG4osqWsdyF4KNKVL2vjP1NK0k0M6X4MneRyZ7zOash_BT9_74BoCwQzh7-t_xp-AbAUjLE</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Elliot, Ari J.</creator><creator>Heffner, Kathi L.</creator><creator>Mooney, Christopher J.</creator><creator>Moynihan, Jan A.</creator><creator>Chapman, Benjamin P.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201807</creationdate><title>Social Relationships and Inflammatory Markers in the MIDUS Cohort: The Role of Age and Gender Differences</title><author>Elliot, Ari J. ; Heffner, Kathi L. ; Mooney, Christopher J. ; Moynihan, Jan A. ; Chapman, Benjamin P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-8171b008e2939e972bc9574723d2d4c540bb62c5e5914c92ffe5b376b61e922c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Female</topic><topic>Gender differences</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sex Factors</topic><topic>Social Support</topic><topic>United States - epidemiology</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elliot, Ari J.</creatorcontrib><creatorcontrib>Heffner, Kathi L.</creatorcontrib><creatorcontrib>Mooney, Christopher J.</creatorcontrib><creatorcontrib>Moynihan, Jan A.</creatorcontrib><creatorcontrib>Chapman, Benjamin P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of aging and health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elliot, Ari J.</au><au>Heffner, Kathi L.</au><au>Mooney, Christopher J.</au><au>Moynihan, Jan A.</au><au>Chapman, Benjamin P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Social Relationships and Inflammatory Markers in the MIDUS Cohort: The Role of Age and Gender Differences</atitle><jtitle>Journal of aging and health</jtitle><addtitle>J Aging Health</addtitle><date>2018-07</date><risdate>2018</risdate><volume>30</volume><issue>6</issue><spage>904</spage><epage>923</epage><pages>904-923</pages><issn>0898-2643</issn><eissn>1552-6887</eissn><abstract>Objective: To better understand age and gender differences in associations of social relationships with chronic inflammation. 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| subjects | Adult Age Age Factors Aged Biomarkers - blood C-Reactive Protein - analysis Female Gender differences Health Surveys Humans Interleukin-6 - blood Longitudinal Studies Male Middle Aged Sex Factors Social Support United States - epidemiology Women |
| title | Social Relationships and Inflammatory Markers in the MIDUS Cohort: The Role of Age and Gender Differences |
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