Digital-to-biological converter for on-demand production of biologics
Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing. Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parell...
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| Veröffentlicht in: | Nature biotechnology 2017-07, Vol.35 (7), p.672-675 |
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| container_title | Nature biotechnology |
| container_volume | 35 |
| creator | Boles, Kent S Kannan, Krishna Gill, John Felderman, Martina Gouvis, Heather Hubby, Bolyn Kamrud, Kurt I Venter, J Craig Gibson, Daniel G |
| description | Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing.
Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization
1
,
2
,
3
. We report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention. |
| doi_str_mv | 10.1038/nbt.3859 |
| format | Article |
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Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization
1
,
2
,
3
. We report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt.3859</identifier><identifier>PMID: 28553942</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>38 ; 38/77 ; 631/337 ; 631/61/185 ; 631/61/51 ; 82 ; 82/1 ; 82/56 ; 82/80 ; Agriculture ; Automation ; Bioinformatics ; Biological activity ; Biological products ; Biological Products - chemistry ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biopolymers - chemistry ; Biotechnology ; Deoxyribonucleic acid ; Digital electronics ; DNA ; Equipment Design ; Equipment Failure Analysis ; Gene sequencing ; Genetic Engineering - instrumentation ; High-Throughput Nucleotide Sequencing - instrumentation ; letter ; Life Sciences ; Manufacturing industry ; Nucleotide sequence ; Production processes ; Proteins ; Ribonucleic acid ; RNA ; Robotics - instrumentation ; Synthetic Biology - instrumentation</subject><ispartof>Nature biotechnology, 2017-07, Vol.35 (7), p.672-675</ispartof><rights>Springer Nature America, Inc. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-ade8261d67b2a95add0e77e483dc79f8d023de2c89b04d16889e6520b3f89d233</citedby><cites>FETCH-LOGICAL-c583t-ade8261d67b2a95add0e77e483dc79f8d023de2c89b04d16889e6520b3f89d233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28553942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boles, Kent S</creatorcontrib><creatorcontrib>Kannan, Krishna</creatorcontrib><creatorcontrib>Gill, John</creatorcontrib><creatorcontrib>Felderman, Martina</creatorcontrib><creatorcontrib>Gouvis, Heather</creatorcontrib><creatorcontrib>Hubby, Bolyn</creatorcontrib><creatorcontrib>Kamrud, Kurt I</creatorcontrib><creatorcontrib>Venter, J Craig</creatorcontrib><creatorcontrib>Gibson, Daniel G</creatorcontrib><title>Digital-to-biological converter for on-demand production of biologics</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing.
Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization
1
,
2
,
3
. We report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention.</description><subject>38</subject><subject>38/77</subject><subject>631/337</subject><subject>631/61/185</subject><subject>631/61/51</subject><subject>82</subject><subject>82/1</subject><subject>82/56</subject><subject>82/80</subject><subject>Agriculture</subject><subject>Automation</subject><subject>Bioinformatics</subject><subject>Biological activity</subject><subject>Biological products</subject><subject>Biological Products - chemistry</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biopolymers - chemistry</subject><subject>Biotechnology</subject><subject>Deoxyribonucleic acid</subject><subject>Digital electronics</subject><subject>DNA</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Gene sequencing</subject><subject>Genetic Engineering - instrumentation</subject><subject>High-Throughput Nucleotide Sequencing - instrumentation</subject><subject>letter</subject><subject>Life Sciences</subject><subject>Manufacturing industry</subject><subject>Nucleotide sequence</subject><subject>Production processes</subject><subject>Proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Robotics - instrumentation</subject><subject>Synthetic Biology - instrumentation</subject><issn>1087-0156</issn><issn>1546-1696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>N95</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl1rFDEYhYMotq6Cv0AGvKngrMkkk4_LUqsWCgW_bkMmeWdMmU1qkhH992bpVneLFxJIQvKcw8vhIPSc4DXBVL4JQ1lT2asH6Jj0jLeEK_6w3rEULSY9P0JPcr7GGHPG-WN01Mm-p4p1x-j8rZ98MXNbYjv4OMfJWzM3NoYfkAqkZoypiaF1sDHBNTcpusUWH0MTx-ZOkJ-iR6OZMzzbnSv05d3557MP7eXV-4uz08vW9pKW1jiQHSeOi6EzqjfOYRACmKTOCjVKhzvqoLNSDZg5wqVUwPsOD3SUynWUrtDJrW-d4_sCueiNzxbm2QSIS9ZEYcqo6CWr6Mt76HVcUqjTVYpIRgQXe9RkZtA-jLEkY7em-pQpSalgNeAVWv-Dqqum4mtUMPr6fiB4dSCoTIGfZTJLzvri08f_Z6--HrKv99hhyT5Arlv207eSbyUH-C4um2LOCUZ9k_zGpF-aYL0tjq7F0dviVPTFLq5l2ID7A9415e-YuX6FCdJenvfNfgPS8MdT</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Boles, Kent S</creator><creator>Kannan, Krishna</creator><creator>Gill, John</creator><creator>Felderman, Martina</creator><creator>Gouvis, Heather</creator><creator>Hubby, Bolyn</creator><creator>Kamrud, Kurt I</creator><creator>Venter, J Craig</creator><creator>Gibson, Daniel G</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>N95</scope><scope>XI7</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>Digital-to-biological converter for on-demand production of biologics</title><author>Boles, Kent S ; Kannan, Krishna ; Gill, John ; Felderman, Martina ; Gouvis, Heather ; Hubby, Bolyn ; Kamrud, Kurt I ; Venter, J Craig ; Gibson, Daniel G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-ade8261d67b2a95add0e77e483dc79f8d023de2c89b04d16889e6520b3f89d233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>38</topic><topic>38/77</topic><topic>631/337</topic><topic>631/61/185</topic><topic>631/61/51</topic><topic>82</topic><topic>82/1</topic><topic>82/56</topic><topic>82/80</topic><topic>Agriculture</topic><topic>Automation</topic><topic>Bioinformatics</topic><topic>Biological activity</topic><topic>Biological products</topic><topic>Biological Products - 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Academic</collection><jtitle>Nature biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boles, Kent S</au><au>Kannan, Krishna</au><au>Gill, John</au><au>Felderman, Martina</au><au>Gouvis, Heather</au><au>Hubby, Bolyn</au><au>Kamrud, Kurt I</au><au>Venter, J Craig</au><au>Gibson, Daniel G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Digital-to-biological converter for on-demand production of biologics</atitle><jtitle>Nature biotechnology</jtitle><stitle>Nat Biotechnol</stitle><addtitle>Nat Biotechnol</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>35</volume><issue>7</issue><spage>672</spage><epage>675</epage><pages>672-675</pages><issn>1087-0156</issn><eissn>1546-1696</eissn><abstract>Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing.
Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization
1
,
2
,
3
. We report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28553942</pmid><doi>10.1038/nbt.3859</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1087-0156 |
| ispartof | Nature biotechnology, 2017-07, Vol.35 (7), p.672-675 |
| issn | 1087-0156 1546-1696 |
| language | eng |
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| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 38 38/77 631/337 631/61/185 631/61/51 82 82/1 82/56 82/80 Agriculture Automation Bioinformatics Biological activity Biological products Biological Products - chemistry Biomedical Engineering/Biotechnology Biomedicine Biopolymers - chemistry Biotechnology Deoxyribonucleic acid Digital electronics DNA Equipment Design Equipment Failure Analysis Gene sequencing Genetic Engineering - instrumentation High-Throughput Nucleotide Sequencing - instrumentation letter Life Sciences Manufacturing industry Nucleotide sequence Production processes Proteins Ribonucleic acid RNA Robotics - instrumentation Synthetic Biology - instrumentation |
| title | Digital-to-biological converter for on-demand production of biologics |
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