Involvement of Reactive Metabolites of Diclofenac in Cytotoxicity in Sandwich-Cultured Rat Hepatocytes

Background and Objectives: Diclofenac (DIC) is metabolized to reactive metabolites such as diclofenac acyl-β-d-glucuronide (DIC-AG). It is possible that such reactive metabolites could cause tissue damage by formation of covalent protein adducts and other modification of cellular proteins or by indu...

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Veröffentlicht in:	International journal of toxicology 2017-05, Vol.36 (3), p.260-267
Hauptverfasser:	Kawase, Atsushi, Hashimoto, Ryota, Shibata, Mai, Shimada, Hiroaki, Iwaki, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - toxicity Cell Survival - drug effects Cells, Cultured Chemical and Drug Induced Liver Injury - metabolism Diclofenac - analogs & derivatives Diclofenac - metabolism Diclofenac - pharmacology Diclofenac - toxicity Glucuronides - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Male Rats, Sprague-Dawley
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