Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade
•Strawberry consumption counteracts oxidative stress in old rats.•Strawberry consumption ameliorates endogenous antioxidant defences in old rats.•Strawberry consumption improves mitochondrial biomass and functionality in old rats.•Strawberry consumption activates AMPK signaling pathway in old rats.•...
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| Veröffentlicht in: | Food chemistry 2017-11, Vol.234, p.464-471 |
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| creator | Giampieri, Francesca Alvarez-Suarez, Josè M. Cordero, Mario D. Gasparrini, Massimiliano Forbes-Hernandez, Tamara Y. Afrin, Sadia Santos-Buelga, Celestino González-Paramás, Ana M. Astolfi, Paola Rubini, Corrado Zizzi, Antonio Tulipani, Sara Quiles, Josè L. Mezzetti, Bruno Battino, Maurizio |
| description | •Strawberry consumption counteracts oxidative stress in old rats.•Strawberry consumption ameliorates endogenous antioxidant defences in old rats.•Strawberry consumption improves mitochondrial biomass and functionality in old rats.•Strawberry consumption activates AMPK signaling pathway in old rats.•AMPK can be a new valuable target for improving aging condition.
Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P |
| doi_str_mv | 10.1016/j.foodchem.2017.05.017 |
| format | Article |
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Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2017.05.017</identifier><identifier>PMID: 28551262</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aging ; AMP-Activated Protein Kinases - metabolism ; AMPK activation ; Animals ; Antioxidants ; Fragaria ; Humans ; Mitochondria ; Mitochondrial functionality ; Organelle Biogenesis ; Oxidative stress ; Rats ; Strawberry polyphenols</subject><ispartof>Food chemistry, 2017-11, Vol.234, p.464-471</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-d36e9b8c00f357679995506a2620b9eca17f4cb26558b08842856e4edb63cb2f3</citedby><cites>FETCH-LOGICAL-c519t-d36e9b8c00f357679995506a2620b9eca17f4cb26558b08842856e4edb63cb2f3</cites><orcidid>0000-0001-8509-1498</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0308814617307896$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28551262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giampieri, Francesca</creatorcontrib><creatorcontrib>Alvarez-Suarez, Josè M.</creatorcontrib><creatorcontrib>Cordero, Mario D.</creatorcontrib><creatorcontrib>Gasparrini, Massimiliano</creatorcontrib><creatorcontrib>Forbes-Hernandez, Tamara Y.</creatorcontrib><creatorcontrib>Afrin, Sadia</creatorcontrib><creatorcontrib>Santos-Buelga, Celestino</creatorcontrib><creatorcontrib>González-Paramás, Ana M.</creatorcontrib><creatorcontrib>Astolfi, Paola</creatorcontrib><creatorcontrib>Rubini, Corrado</creatorcontrib><creatorcontrib>Zizzi, Antonio</creatorcontrib><creatorcontrib>Tulipani, Sara</creatorcontrib><creatorcontrib>Quiles, Josè L.</creatorcontrib><creatorcontrib>Mezzetti, Bruno</creatorcontrib><creatorcontrib>Battino, Maurizio</creatorcontrib><title>Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>•Strawberry consumption counteracts oxidative stress in old rats.•Strawberry consumption ameliorates endogenous antioxidant defences in old rats.•Strawberry consumption improves mitochondrial biomass and functionality in old rats.•Strawberry consumption activates AMPK signaling pathway in old rats.•AMPK can be a new valuable target for improving aging condition.
Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.</description><subject>Aging</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>AMPK activation</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Fragaria</subject><subject>Humans</subject><subject>Mitochondria</subject><subject>Mitochondrial functionality</subject><subject>Organelle Biogenesis</subject><subject>Oxidative stress</subject><subject>Rats</subject><subject>Strawberry polyphenols</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCITgu_UHnJggQ7iR1nR1XxqFREpcLacuybjIfEHmxn0HxPfxSHadl2dSTf87jXB6FLSkpKKP-wKwfvjd7CXFaEtiVhZYYXaENFWxctaauXaENqIgpBG36GzmPcEUIyV7xGZ5VgjFa82qCH-xTUnx5COGLtXVzmfbLeYTvvgz9AxGq0bixUjF5blcCsE2XDDC7F93i2yeutdyZYNeHe-hEcRJtlzuBhcXo1U5NNR5y2wS_jNiPgq293hcqzwz_HnJTAOvzLOhUBRzuuEjdiraJWBt6gV4OaIrx9xAv08_OnH9dfi9vvX26ur24LzWiXClNz6HqhCRlq1vK26zrGCFf5TtJ3oBVth0b3FWdM9ESIJv8ChwZMz-v8PNQX6N3JNy_0e4GY5GyjhmlSDvwSJe1I3dRcNCRT-Ymqg48xwCD3wc4qHCUlci1I7uRTQXItSBImM2Th5WPG0s9g_sueGsmEjycC5EsPFoKM2oLTYGwAnaTx9rmMv8JwqiY</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Giampieri, Francesca</creator><creator>Alvarez-Suarez, Josè M.</creator><creator>Cordero, Mario D.</creator><creator>Gasparrini, Massimiliano</creator><creator>Forbes-Hernandez, Tamara Y.</creator><creator>Afrin, Sadia</creator><creator>Santos-Buelga, Celestino</creator><creator>González-Paramás, Ana M.</creator><creator>Astolfi, Paola</creator><creator>Rubini, Corrado</creator><creator>Zizzi, Antonio</creator><creator>Tulipani, Sara</creator><creator>Quiles, Josè L.</creator><creator>Mezzetti, Bruno</creator><creator>Battino, Maurizio</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8509-1498</orcidid></search><sort><creationdate>20171101</creationdate><title>Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade</title><author>Giampieri, Francesca ; Alvarez-Suarez, Josè M. ; Cordero, Mario D. ; Gasparrini, Massimiliano ; Forbes-Hernandez, Tamara Y. ; Afrin, Sadia ; Santos-Buelga, Celestino ; González-Paramás, Ana M. ; Astolfi, Paola ; Rubini, Corrado ; Zizzi, Antonio ; Tulipani, Sara ; Quiles, Josè L. ; Mezzetti, Bruno ; Battino, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-d36e9b8c00f357679995506a2620b9eca17f4cb26558b08842856e4edb63cb2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aging</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>AMPK activation</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Fragaria</topic><topic>Humans</topic><topic>Mitochondria</topic><topic>Mitochondrial functionality</topic><topic>Organelle Biogenesis</topic><topic>Oxidative stress</topic><topic>Rats</topic><topic>Strawberry polyphenols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giampieri, Francesca</creatorcontrib><creatorcontrib>Alvarez-Suarez, Josè M.</creatorcontrib><creatorcontrib>Cordero, Mario D.</creatorcontrib><creatorcontrib>Gasparrini, Massimiliano</creatorcontrib><creatorcontrib>Forbes-Hernandez, Tamara Y.</creatorcontrib><creatorcontrib>Afrin, Sadia</creatorcontrib><creatorcontrib>Santos-Buelga, Celestino</creatorcontrib><creatorcontrib>González-Paramás, Ana M.</creatorcontrib><creatorcontrib>Astolfi, Paola</creatorcontrib><creatorcontrib>Rubini, Corrado</creatorcontrib><creatorcontrib>Zizzi, Antonio</creatorcontrib><creatorcontrib>Tulipani, Sara</creatorcontrib><creatorcontrib>Quiles, Josè L.</creatorcontrib><creatorcontrib>Mezzetti, Bruno</creatorcontrib><creatorcontrib>Battino, Maurizio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giampieri, Francesca</au><au>Alvarez-Suarez, Josè M.</au><au>Cordero, Mario D.</au><au>Gasparrini, Massimiliano</au><au>Forbes-Hernandez, Tamara Y.</au><au>Afrin, Sadia</au><au>Santos-Buelga, Celestino</au><au>González-Paramás, Ana M.</au><au>Astolfi, Paola</au><au>Rubini, Corrado</au><au>Zizzi, Antonio</au><au>Tulipani, Sara</au><au>Quiles, Josè L.</au><au>Mezzetti, Bruno</au><au>Battino, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>234</volume><spage>464</spage><epage>471</epage><pages>464-471</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><abstract>•Strawberry consumption counteracts oxidative stress in old rats.•Strawberry consumption ameliorates endogenous antioxidant defences in old rats.•Strawberry consumption improves mitochondrial biomass and functionality in old rats.•Strawberry consumption activates AMPK signaling pathway in old rats.•AMPK can be a new valuable target for improving aging condition.
Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28551262</pmid><doi>10.1016/j.foodchem.2017.05.017</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8509-1498</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aging AMP-Activated Protein Kinases - metabolism AMPK activation Animals Antioxidants Fragaria Humans Mitochondria Mitochondrial functionality Organelle Biogenesis Oxidative stress Rats Strawberry polyphenols |
| title | Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade |
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