An in-depth analysis identifies two new independent signals in 11q23.3 associated with vitiligo in the Chinese Han population

Highlights • Three SNPs (rs613791, rs523604, rs638893) showed significant association with vitiligo in the study in Han Chinese population. • Previously reported SNP rs638893 was replicated, two newly identified SNPs (rs613791 and rs523604) were all independent of the reported SNP rs638893, and they...

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Veröffentlicht in:	Journal of dermatological science 2017-10, Vol.88 (1), p.103-109
Hauptverfasser:	Zhao, Suli, Fang, Fang, Tang, Xianfa, Dou, Jinfa, Wang, Wenjun, Zheng, Xiaodong, Sun, Liangdan, Zhang, Anping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Alleles Asian Continental Ancestry Group - genetics Autoimmune Diseases - genetics Child Child, Preschool Chromosomes, Human, Pair 11 - genetics CXCR5 DDX6 Dermatology Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Genotyping Techniques - methods Humans Infant Male Middle Aged Multiplex Polymerase Chain Reaction Oligonucleotide Array Sequence Analysis Polymorphism, Single Nucleotide Receptors, CXCR5 - genetics Susceptibility gene Vitiligo Vitiligo - genetics Young Adult
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Zusammenfassung:	Highlights • Three SNPs (rs613791, rs523604, rs638893) showed significant association with vitiligo in the study in Han Chinese population. • Previously reported SNP rs638893 was replicated, two newly identified SNPs (rs613791 and rs523604) were all independent of the reported SNP rs638893, and they were also independent of each other. • SNP rs523604 and rs613791 are located in CXCR5, and CXCR5 is crucial for follicular helper T cells (Tfh), which plays a key role in the pathogenesis of autoimmune diseases.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2017.05.001