Assessment of the Effects of 2′-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates

Decreases in platelet (PLT) counts observed in nonhuman primates (NHPs) given 2′-O-methoxyethyl modified antisense inhibitors (2′-MOE ASOs) have been reported, but the incidence and severity of the change vary considerably between sequences, studies, and animals. This article will broadly illustrate...

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Veröffentlicht in:	Nucleic acid therapeutics 2017-08, Vol.27 (4), p.197-208
Hauptverfasser:	Henry, Scott P., Narayanan, Padmakumar, Shen, Lijiang, Bhanot, Sanjay, Younis, Husam S., Burel, Sebastien A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense oligonucleotides Blood platelets Clinical trials Clinical Trials, Phase II as Topic Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Dose-Response Relationship, Drug Double-Blind Method Drug Evaluation, Preclinical Female Gene expression Humans Incidence Macaca fascicularis Male Monkeys & apes Oligonucleotides Oligonucleotides, Antisense - toxicity Original Articles Patients Pharmacology Platelet Count Platelets Polymers Primates Reduction
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