PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS

Poly(adenosine diphosphate ribose) polymerases (PARPs) are multifunctional proteins which play a role in many cellular processes. Namely, PARP1 and PARP2 have been shown to be involved in DNA repair, and therefore are valid targets in cancer treatment with PARP inhibitors, such as rucaparib, current...

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Veröffentlicht in:	NMR in biomedicine 2017-09, Vol.30 (9), p.n/a
Hauptverfasser:	Almeida, Gilberto S., Bawn, Carlo M., Galler, Martin, Wilson, Ian, Thomas, Huw D., Kyle, Suzanne, Curtin, Nicola J., Newell, David R., Maxwell, Ross J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine diphosphate Animals Biological products Biomarkers Biotechnology Cancer Cell Line, Tumor Clinical trials Depletion DNA repair Hepatocytes Humans Indoles - pharmacology Inhibitors Liver Liver - metabolism Magnetic resonance spectroscopy Mice, Knockout molecular imaging MRS NAD NAD - chemistry NAD - metabolism Nicotinamide NMR Nuclear magnetic resonance Ovarian cancer PARP inhibitor Perchloric acid Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Proton magnetic resonance Proton Magnetic Resonance Spectroscopy - methods Ribose Rodents Spectroscopy Spectrum analysis Temozolomide Tumor cell lines Tumors
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