Improvement of hydration and epidermal barrier function in human skin by a novel compound isosorbide dicaprylate

Objective The study involved the synthesis of a novel derivative of caprylic acid – isosorbide dicaprylate (IDC) – and the evaluation of its potential in improving water homoeostasis and epidermal barrier function in human skin. Methods The effect of IDC on gene expression was assayed in skin organo...

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Veröffentlicht in:	International journal of cosmetic science 2017-10, Vol.39 (5), p.518-526
Hauptverfasser:	Chaudhuri, R. K., Bojanowski, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Aquaporin 3 Aquaporin 3 - metabolism Barriers Body Water Cadherins - genetics Caprylates - administration & dosage Caprylates - pharmacology CD44 antigen Cell Differentiation - drug effects ceramide synthase Cosmetics industry Cytochemistry Deoxyribonucleic acid Differentiation DNA DNA microarrays Emollients - administration & dosage Epidermis - drug effects Epidermis - metabolism Gene expression Genes Glycerol Glycerol - administration & dosage human clinical Humans Hyaluronan Receptors - metabolism hyaluronic acid receptor Hydration isosorbide dicaprylate Keratinocytes - cytology Keratinocytes - drug effects Lotions Octanoic acid Oligonucleotide Array Sequence Analysis Permeability Placebos Polymerase Chain Reaction Proteins RNA, Messenger - genetics Skin Stratum corneum Structure-function relationships Therapeutic applications Up-Regulation - drug effects Water - metabolism Water loss
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