A Critical Role for IL-21 Receptor Signaling in the Coxsackievirus B3-Induced Myocarditis

To determine whether IL-21 receptor signaling plays a significant role in promoting Tfh cell-mediated cardiac injury in viral myocarditis (VMC), we compared IL-21R-deficient mice for some parameters of VMC. Balb/c and IL-21R −/− mice were infected with CVB3. Frequencies of splenic Tfh cells were det...

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Veröffentlicht in:	Inflammation 2017-08, Vol.40 (4), p.1428-1435
Hauptverfasser:	Yang, Fan, Wei, Xiao-mou, Liang, Wen-wu, Mo, Wen-hong, Tan, Bao-ping, Wang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adenine Nucleotide Translocator 1 - immunology Animals Antibodies Autoantibodies Autoantibodies - analysis B-Lymphocytes - cytology Biomedical and Life Sciences Biomedicine CD19 antigen Cell Proliferation Coxsackieviruses Enterovirus B, Human - pathogenicity Enzyme-linked immunosorbent assay Flow cytometry Heart diseases Immunology Interleukin 21 Interleukins - metabolism Internal Medicine Lipopolysaccharides Lymphocytes B Mice, Inbred BALB C Mice, Knockout Myocarditis Myocarditis - virology Myocardium Original Article Pathology Pharmacology/Toxicology Receptors, Interleukin-21 - deficiency Receptors, Interleukin-21 - metabolism Rheumatology Rodents Signal Transduction Spleen
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