Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

Higher lipid solubility of lipophilic salt forms creates new product development opportunities for high-dose liquid-filled capsules. The purpose of this study is to determine if lipophilic salts of Biopharmaceutical Classification System (BCS) Class I amlodipine and BCS Class III fexofenadine, ranit...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2018-01, Vol.107 (1), p.203-216
Hauptverfasser:	Williams, Hywel D., Ford, Leigh, Lim, Shea, Han, Sifei, Baumann, John, Sullivan, Hannah, Vodak, David, Igonin, Annabel, Benameur, Hassan, Pouton, Colin W., Scammells, Peter J., Porter, Christopher J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopharmaceutics classification system Capsules - chemistry Chemistry, Pharmaceutical - methods developability Drug Delivery Systems - methods Excipients - chemistry formulation vehicle Ionic Liquids - chemistry lipids Lipids - chemistry oral drug delivery Pharmaceutical Preparations - chemistry Salts - chemistry salts/salt selection self-emulsifying Solubility zwitterion
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