IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis

Gut homeostasis is a tightly regulated process requiring finely tuned complex interactions between different cell types, growth factors, or cytokines and their receptors. Previous work has implicated a role for IL-6 and mucosal immune cells in intestinal regeneration following injury and in promotin...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-07, Vol.199 (1), p.304-311
Hauptverfasser:	Jeffery, Victoria, Goldson, Andrew J, Dainty, Jack R, Chieppa, Marcello, Sobolewski, Anastasia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Autocrine signalling Budding Cancer Cell activation Cell Differentiation Cell proliferation Cell Proliferation - drug effects Digestive system Epithelium Gastrointestinal tract Gene Expression Regulation Growth factors Homeostasis Immunoglobulin G Immunoglobulin G - administration & dosage Immunoglobulin G - immunology Interleukin 6 Interleukin 6 receptors Interleukin-6 - genetics Interleukin-6 - metabolism Interleukin-6 - pharmacology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - physiology Intestine Intestine, Small - metabolism Mice Mucosal immunity Nuclei Nuclei (cytology) Organ Culture Techniques Organoids Paneth cells Paneth Cells - drug effects Paneth Cells - immunology Receptors, Interleukin-6 - immunology Receptors, Interleukin-6 - metabolism Rodents Signal transduction Small intestine STAT3 Transcription Factor - genetics STAT3 Transcription Factor - immunology STAT3 Transcription Factor - metabolism Stem cell transplantation Stem cells Stem Cells - drug effects Stem Cells - immunology Stem Cells - physiology Wnt protein Wnt Signaling Pathway
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