2-Adamantanamine produces prolonged spinal block in rats

•Intrathecal 2-adamantanamine provoked spinal block dose-dependently.•2-Adamantanamine was less potent than mepivacaine in spinal anesthesia.•2-Adamantanamine produced more nociceptive block than motor block.•The duration caused by 2-adamantanamine was longer than that caused by mepivacaine. We aime...

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Veröffentlicht in:	Neuroscience letters 2017-07, Vol.653, p.168-172
Hauptverfasser:	Chen, Yu-Wen, Chen, Chia-Ming, Liu, Kuo-Sheng, Wang, Jhi-Joung, Hung, Ching-Hsia
Format:	Artikel
Sprache:	eng
Schlagworte:	2-adamantanamine Amantadine - administration & dosage Amantadine - analogs & derivatives Anesthetics - administration & dosage Animals Dose-Response Relationship, Drug Injections, Spinal Intrathecal injection Male Mepivacaine Mepivacaine - administration & dosage Motor Activity - drug effects Motor function Nerve Block - methods Nociception Nociception - drug effects Proprioception Proprioception - drug effects Rats, Sprague-Dawley
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