Astronaut ophthalmic syndrome
ABSTRACT During and after missions on the International Space Station, some astronauts experience ophthalmic changes, including choroidal folds, optic disc edema, cotton‐wool spots, globe flattening, and refraction changes. Astronauts with ophthalmic issues had significantly higher plasma concentrat...
Gespeichert in:
| Veröffentlicht in: | The FASEB journal 2017-09, Vol.31 (9), p.3746-3756 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3756 |
|---|---|
| container_issue | 9 |
| container_start_page | 3746 |
| container_title | The FASEB journal |
| container_volume | 31 |
| creator | Zwart, Sara R. Gibson, Charles R. Gregory, Jesse F. Mader, Thomas H. Stover, Patrick J. Zeisel, Steven H. Smith, Scott M. |
| description | ABSTRACT
During and after missions on the International Space Station, some astronauts experience ophthalmic changes, including choroidal folds, optic disc edema, cotton‐wool spots, globe flattening, and refraction changes. Astronauts with ophthalmic issues had significantly higher plasma concentrations of metabolites that are associated with the 1‐carbon metabolic pathway than those without ophthalmic issues. We hypothesized that genetic differences might explain the metabolite differences. Indeed, genetics and B vitamin status were significant predictors of ophthalmic issues. We now have developed a hypothesis regarding the mechanisms that link 1‐carbon pathway genetics and the condition that we suggest calling, “astronaut ophthalmic syndrome.” We maintain that this condition is genetically predisposed and is associated with endothelial dysfunction that is induced by oxidative stress. Subsequent edema can hinder cerebrospinal fluid efflux and can lead to locally increased pressures in the subarachnoid space within the orbit, which impinges on the optic nerve and/or eye in affected individuals. Confirming this hypothesis will help characterize the genetics of 1‐carbon pathway metabolism, homocysteine, oxidative stress, endothelial dysfunction, and cardiovascular and potentially other diseases.—Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., Smith, S. M. Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017). www.fasebj.org—Zwart, Sara R., Gibson, Charles R., Gregory, Jesse F., Mader, Thomas H., Stover, Patrick J., Zeisel, Steven H., Smith, Scott M., Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017) |
| doi_str_mv | 10.1096/fj.201700294 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1903159647</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1984080516</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4074-d200f4bd159bb3e96675522a8c1b1f296702d367f9b965a563556528b66ef8663</originalsourceid><addsrcrecordid>eNp90EtLAzEUhuEgiq3VnVul4MaFU08yyZlk2RbrhYILdR3mktAZ5lKTGaT_3imtFVy4OpuHl8NHyCWFCQWF97aYMKARAFP8iAypCCFAiXBMhiAVCxBDOSBn3hcAQIHiKRkwKThyHg7J1dS3rqnjrh0361W7issqT8d-U2euqcw5ObFx6c3F_o7Ix-Lhff4ULF8fn-fTZZByiHiQMQDLk4wKlSShUYiREIzFMqUJtUxhBCwLMbIqUShigaEQKJhMEI2V_YMjcrvrrl3z2Rnf6ir3qSnLuDZN5zVVEPZx5FFPb_7Qoulc3X_XK8lBgqDb4N1Opa7x3hmr1y6vYrfRFPR2Nm0LfZit59f7aJdUJjvgn516oHbgKy_N5t-YXrzN2OLlN_4Nsch0tw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1984080516</pqid></control><display><type>article</type><title>Astronaut ophthalmic syndrome</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Zwart, Sara R. ; Gibson, Charles R. ; Gregory, Jesse F. ; Mader, Thomas H. ; Stover, Patrick J. ; Zeisel, Steven H. ; Smith, Scott M.</creator><creatorcontrib>Zwart, Sara R. ; Gibson, Charles R. ; Gregory, Jesse F. ; Mader, Thomas H. ; Stover, Patrick J. ; Zeisel, Steven H. ; Smith, Scott M.</creatorcontrib><description>ABSTRACT
During and after missions on the International Space Station, some astronauts experience ophthalmic changes, including choroidal folds, optic disc edema, cotton‐wool spots, globe flattening, and refraction changes. Astronauts with ophthalmic issues had significantly higher plasma concentrations of metabolites that are associated with the 1‐carbon metabolic pathway than those without ophthalmic issues. We hypothesized that genetic differences might explain the metabolite differences. Indeed, genetics and B vitamin status were significant predictors of ophthalmic issues. We now have developed a hypothesis regarding the mechanisms that link 1‐carbon pathway genetics and the condition that we suggest calling, “astronaut ophthalmic syndrome.” We maintain that this condition is genetically predisposed and is associated with endothelial dysfunction that is induced by oxidative stress. Subsequent edema can hinder cerebrospinal fluid efflux and can lead to locally increased pressures in the subarachnoid space within the orbit, which impinges on the optic nerve and/or eye in affected individuals. Confirming this hypothesis will help characterize the genetics of 1‐carbon pathway metabolism, homocysteine, oxidative stress, endothelial dysfunction, and cardiovascular and potentially other diseases.—Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., Smith, S. M. Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017). www.fasebj.org—Zwart, Sara R., Gibson, Charles R., Gregory, Jesse F., Mader, Thomas H., Stover, Patrick J., Zeisel, Steven H., Smith, Scott M., Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017)</description><identifier>ISSN: 0892-6638</identifier><identifier>EISSN: 1530-6860</identifier><identifier>DOI: 10.1096/fj.201700294</identifier><identifier>PMID: 28546443</identifier><language>eng</language><publisher>United States: Federation of American Societies for Experimental Biology (FASEB)</publisher><subject>Aerospace Medicine ; Astronauts ; B vitamins ; Carbon ; Carbon Dioxide ; Cerebrospinal fluid ; Edema ; Edema - etiology ; Edema - pathology ; Efflux ; endothelial dysfunction ; Genetic Predisposition to Disease ; Genetics ; Homocysteine ; Humans ; Hypotheses ; International Space Station ; Metabolism ; Metabolites ; microgravity ; Optic nerve ; Oxidative metabolism ; Oxidative stress ; Space Flight ; Space missions ; Subarachnoid space ; Vision Disorders - etiology ; Vision Disorders - genetics ; Vision Disorders - physiopathology ; Vitamin B Complex - blood ; Vitamin B Complex - metabolism ; Weightlessness</subject><ispartof>The FASEB journal, 2017-09, Vol.31 (9), p.3746-3756</ispartof><rights>FASEB</rights><rights>FASEB.</rights><rights>Copyright Federation of American Societies for Experimental Biology (FASEB) Sep 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4074-d200f4bd159bb3e96675522a8c1b1f296702d367f9b965a563556528b66ef8663</citedby><cites>FETCH-LOGICAL-c4074-d200f4bd159bb3e96675522a8c1b1f296702d367f9b965a563556528b66ef8663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1096%2Ffj.201700294$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1096%2Ffj.201700294$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28546443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zwart, Sara R.</creatorcontrib><creatorcontrib>Gibson, Charles R.</creatorcontrib><creatorcontrib>Gregory, Jesse F.</creatorcontrib><creatorcontrib>Mader, Thomas H.</creatorcontrib><creatorcontrib>Stover, Patrick J.</creatorcontrib><creatorcontrib>Zeisel, Steven H.</creatorcontrib><creatorcontrib>Smith, Scott M.</creatorcontrib><title>Astronaut ophthalmic syndrome</title><title>The FASEB journal</title><addtitle>FASEB J</addtitle><description>ABSTRACT
During and after missions on the International Space Station, some astronauts experience ophthalmic changes, including choroidal folds, optic disc edema, cotton‐wool spots, globe flattening, and refraction changes. Astronauts with ophthalmic issues had significantly higher plasma concentrations of metabolites that are associated with the 1‐carbon metabolic pathway than those without ophthalmic issues. We hypothesized that genetic differences might explain the metabolite differences. Indeed, genetics and B vitamin status were significant predictors of ophthalmic issues. We now have developed a hypothesis regarding the mechanisms that link 1‐carbon pathway genetics and the condition that we suggest calling, “astronaut ophthalmic syndrome.” We maintain that this condition is genetically predisposed and is associated with endothelial dysfunction that is induced by oxidative stress. Subsequent edema can hinder cerebrospinal fluid efflux and can lead to locally increased pressures in the subarachnoid space within the orbit, which impinges on the optic nerve and/or eye in affected individuals. Confirming this hypothesis will help characterize the genetics of 1‐carbon pathway metabolism, homocysteine, oxidative stress, endothelial dysfunction, and cardiovascular and potentially other diseases.—Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., Smith, S. M. Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017). www.fasebj.org—Zwart, Sara R., Gibson, Charles R., Gregory, Jesse F., Mader, Thomas H., Stover, Patrick J., Zeisel, Steven H., Smith, Scott M., Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017)</description><subject>Aerospace Medicine</subject><subject>Astronauts</subject><subject>B vitamins</subject><subject>Carbon</subject><subject>Carbon Dioxide</subject><subject>Cerebrospinal fluid</subject><subject>Edema</subject><subject>Edema - etiology</subject><subject>Edema - pathology</subject><subject>Efflux</subject><subject>endothelial dysfunction</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>International Space Station</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>microgravity</subject><subject>Optic nerve</subject><subject>Oxidative metabolism</subject><subject>Oxidative stress</subject><subject>Space Flight</subject><subject>Space missions</subject><subject>Subarachnoid space</subject><subject>Vision Disorders - etiology</subject><subject>Vision Disorders - genetics</subject><subject>Vision Disorders - physiopathology</subject><subject>Vitamin B Complex - blood</subject><subject>Vitamin B Complex - metabolism</subject><subject>Weightlessness</subject><issn>0892-6638</issn><issn>1530-6860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EtLAzEUhuEgiq3VnVul4MaFU08yyZlk2RbrhYILdR3mktAZ5lKTGaT_3imtFVy4OpuHl8NHyCWFCQWF97aYMKARAFP8iAypCCFAiXBMhiAVCxBDOSBn3hcAQIHiKRkwKThyHg7J1dS3rqnjrh0361W7issqT8d-U2euqcw5ObFx6c3F_o7Ix-Lhff4ULF8fn-fTZZByiHiQMQDLk4wKlSShUYiREIzFMqUJtUxhBCwLMbIqUShigaEQKJhMEI2V_YMjcrvrrl3z2Rnf6ir3qSnLuDZN5zVVEPZx5FFPb_7Qoulc3X_XK8lBgqDb4N1Opa7x3hmr1y6vYrfRFPR2Nm0LfZit59f7aJdUJjvgn516oHbgKy_N5t-YXrzN2OLlN_4Nsch0tw</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Zwart, Sara R.</creator><creator>Gibson, Charles R.</creator><creator>Gregory, Jesse F.</creator><creator>Mader, Thomas H.</creator><creator>Stover, Patrick J.</creator><creator>Zeisel, Steven H.</creator><creator>Smith, Scott M.</creator><general>Federation of American Societies for Experimental Biology (FASEB)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Astronaut ophthalmic syndrome</title><author>Zwart, Sara R. ; Gibson, Charles R. ; Gregory, Jesse F. ; Mader, Thomas H. ; Stover, Patrick J. ; Zeisel, Steven H. ; Smith, Scott M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4074-d200f4bd159bb3e96675522a8c1b1f296702d367f9b965a563556528b66ef8663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aerospace Medicine</topic><topic>Astronauts</topic><topic>B vitamins</topic><topic>Carbon</topic><topic>Carbon Dioxide</topic><topic>Cerebrospinal fluid</topic><topic>Edema</topic><topic>Edema - etiology</topic><topic>Edema - pathology</topic><topic>Efflux</topic><topic>endothelial dysfunction</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>International Space Station</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>microgravity</topic><topic>Optic nerve</topic><topic>Oxidative metabolism</topic><topic>Oxidative stress</topic><topic>Space Flight</topic><topic>Space missions</topic><topic>Subarachnoid space</topic><topic>Vision Disorders - etiology</topic><topic>Vision Disorders - genetics</topic><topic>Vision Disorders - physiopathology</topic><topic>Vitamin B Complex - blood</topic><topic>Vitamin B Complex - metabolism</topic><topic>Weightlessness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zwart, Sara R.</creatorcontrib><creatorcontrib>Gibson, Charles R.</creatorcontrib><creatorcontrib>Gregory, Jesse F.</creatorcontrib><creatorcontrib>Mader, Thomas H.</creatorcontrib><creatorcontrib>Stover, Patrick J.</creatorcontrib><creatorcontrib>Zeisel, Steven H.</creatorcontrib><creatorcontrib>Smith, Scott M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The FASEB journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zwart, Sara R.</au><au>Gibson, Charles R.</au><au>Gregory, Jesse F.</au><au>Mader, Thomas H.</au><au>Stover, Patrick J.</au><au>Zeisel, Steven H.</au><au>Smith, Scott M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astronaut ophthalmic syndrome</atitle><jtitle>The FASEB journal</jtitle><addtitle>FASEB J</addtitle><date>2017-09</date><risdate>2017</risdate><volume>31</volume><issue>9</issue><spage>3746</spage><epage>3756</epage><pages>3746-3756</pages><issn>0892-6638</issn><eissn>1530-6860</eissn><abstract>ABSTRACT
During and after missions on the International Space Station, some astronauts experience ophthalmic changes, including choroidal folds, optic disc edema, cotton‐wool spots, globe flattening, and refraction changes. Astronauts with ophthalmic issues had significantly higher plasma concentrations of metabolites that are associated with the 1‐carbon metabolic pathway than those without ophthalmic issues. We hypothesized that genetic differences might explain the metabolite differences. Indeed, genetics and B vitamin status were significant predictors of ophthalmic issues. We now have developed a hypothesis regarding the mechanisms that link 1‐carbon pathway genetics and the condition that we suggest calling, “astronaut ophthalmic syndrome.” We maintain that this condition is genetically predisposed and is associated with endothelial dysfunction that is induced by oxidative stress. Subsequent edema can hinder cerebrospinal fluid efflux and can lead to locally increased pressures in the subarachnoid space within the orbit, which impinges on the optic nerve and/or eye in affected individuals. Confirming this hypothesis will help characterize the genetics of 1‐carbon pathway metabolism, homocysteine, oxidative stress, endothelial dysfunction, and cardiovascular and potentially other diseases.—Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., Smith, S. M. Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017). www.fasebj.org—Zwart, Sara R., Gibson, Charles R., Gregory, Jesse F., Mader, Thomas H., Stover, Patrick J., Zeisel, Steven H., Smith, Scott M., Astronaut ophthalmic syndrome. FASEB J. 31, 3746–3756 (2017)</abstract><cop>United States</cop><pub>Federation of American Societies for Experimental Biology (FASEB)</pub><pmid>28546443</pmid><doi>10.1096/fj.201700294</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-6638 |
| ispartof | The FASEB journal, 2017-09, Vol.31 (9), p.3746-3756 |
| issn | 0892-6638 1530-6860 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1903159647 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Aerospace Medicine Astronauts B vitamins Carbon Carbon Dioxide Cerebrospinal fluid Edema Edema - etiology Edema - pathology Efflux endothelial dysfunction Genetic Predisposition to Disease Genetics Homocysteine Humans Hypotheses International Space Station Metabolism Metabolites microgravity Optic nerve Oxidative metabolism Oxidative stress Space Flight Space missions Subarachnoid space Vision Disorders - etiology Vision Disorders - genetics Vision Disorders - physiopathology Vitamin B Complex - blood Vitamin B Complex - metabolism Weightlessness |
| title | Astronaut ophthalmic syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T11%3A20%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Astronaut%20ophthalmic%20syndrome&rft.jtitle=The%20FASEB%20journal&rft.au=Zwart,%20Sara%20R.&rft.date=2017-09&rft.volume=31&rft.issue=9&rft.spage=3746&rft.epage=3756&rft.pages=3746-3756&rft.issn=0892-6638&rft.eissn=1530-6860&rft_id=info:doi/10.1096/fj.201700294&rft_dat=%3Cproquest_cross%3E1984080516%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1984080516&rft_id=info:pmid/28546443&rfr_iscdi=true |