Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study

Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. Given this association, we hypothesized that the cen...

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Veröffentlicht in:	Alzheimer disease and associated disorders 2017-04, Vol.31 (2), p.107-113
Hauptverfasser:	Koenig, Aaron M, Mechanic-Hamilton, Dawn, Xie, Sharon X, Combs, Martha F, Cappola, Anne R, Xie, Long, Detre, John A, Wolk, David A, Arnold, Steven E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnostic imaging Alzheimer Disease - drug therapy Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - drug therapy Cross-Over Studies Diabetes Mellitus, Type 2 - drug therapy Female Humans Hypoglycemic Agents - therapeutic use Male Metformin - therapeutic use Neuropsychological Tests - statistics & numerical data
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