Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study
Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and sa...
Gespeichert in:
| Veröffentlicht in: | Japanese journal of clinical oncology 2017-09, Vol.47 (9), p.820-825 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 825 |
|---|---|
| container_issue | 9 |
| container_start_page | 820 |
| container_title | Japanese journal of clinical oncology |
| container_volume | 47 |
| creator | Koyama, Daisuke Nishiwaki, Satoshi Harada, Yasuhiko Yamamoto, Satomi Kurahashi, Shingo Sugimoto, Takumi Iwasaki, Toshihiro Sugiura, Isamu |
| description | Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen).
We retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1-4) and cytarabine (100 mg/m2/day, days 1-4)] at Toyohashi municipal hospital from 2004 to 2013.
The median age of the patients was 55 years. The most common underlying diseases were diffuse large B-cell lymphoma (46%) and follicular lymphoma (26%). Three-quarters of patients were in their second complete or partial remission. The median total number of collected CD34+ cells was 10.6 × 106 kg-1. Forty-two patients (91%) yielded at least 2 × 106 kg-1 CD34+ cells within a median of 2 apheresis days, and 33 patients (72%) achieved it with only one apheresis. Successful mobilization was observed in five of six patients who failed to mobilize previously. Although febrile neutropenia occurred in 22 patients (48%), no fatal infection was observed.
The EC regimen was highly effective in lymphoma patients, including patients who mobilized poorly with other regimens. |
| doi_str_mv | 10.1093/jjco/hyx076 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1902482314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1902482314</sourcerecordid><originalsourceid>FETCH-LOGICAL-c350t-ca704c97b3b2c9201b7e02c3c02d3e6bfa301b10c11a4494cc51cd87e60a51bd3</originalsourceid><addsrcrecordid>eNo9kU1P3DAQhq0KVLa0p96Rj6BuwJ_56K1abSnSSlzoObInE9arJA62lzb8iv7kBhY4jWb0zPuO5iXkK2eXnFXyarcDf7Wd_rIi_0AWXOU6k7ngR2TBZF5mouT8hHyKcccY06UqPpITUWrFtdYL8m_dtgjJPSKFLfa-99Z17skk5wf6x6UtxeRHH12D1AwNhSmZYKwbkJ6vVzTgvetxuKBuoN3Uj1vfGzrO2zik-J0aGt1w32EGc49hOfMp-DgeHJfU24jh8cXMdDSmfTN9Jset6SJ-ea2n5PfP9d3qV7a5vb5Z_dhkIDVLGZiCKagKK62ASjBuC2QCJDDRSMxta-Q84ww4N0pVCkBzaMoCc2Y0t408JecH3TH4hz3GVPcuAnadGdDvY80rJlQpJFcz-u2Awnx7DNjWY3C9CVPNWf0cQf0cQX2IYKbPXoX3tsfmnX37ufwP9HmGyw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1902482314</pqid></control><display><type>article</type><title>Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Koyama, Daisuke ; Nishiwaki, Satoshi ; Harada, Yasuhiko ; Yamamoto, Satomi ; Kurahashi, Shingo ; Sugimoto, Takumi ; Iwasaki, Toshihiro ; Sugiura, Isamu</creator><creatorcontrib>Koyama, Daisuke ; Nishiwaki, Satoshi ; Harada, Yasuhiko ; Yamamoto, Satomi ; Kurahashi, Shingo ; Sugimoto, Takumi ; Iwasaki, Toshihiro ; Sugiura, Isamu</creatorcontrib><description>Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen).
We retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1-4) and cytarabine (100 mg/m2/day, days 1-4)] at Toyohashi municipal hospital from 2004 to 2013.
The median age of the patients was 55 years. The most common underlying diseases were diffuse large B-cell lymphoma (46%) and follicular lymphoma (26%). Three-quarters of patients were in their second complete or partial remission. The median total number of collected CD34+ cells was 10.6 × 106 kg-1. Forty-two patients (91%) yielded at least 2 × 106 kg-1 CD34+ cells within a median of 2 apheresis days, and 33 patients (72%) achieved it with only one apheresis. Successful mobilization was observed in five of six patients who failed to mobilize previously. Although febrile neutropenia occurred in 22 patients (48%), no fatal infection was observed.
The EC regimen was highly effective in lymphoma patients, including patients who mobilized poorly with other regimens.</description><identifier>ISSN: 0368-2811</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyx076</identifier><identifier>PMID: 28541555</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Antimetabolites, Antineoplastic - administration & dosage ; Antimetabolites, Antineoplastic - pharmacology ; Antimetabolites, Antineoplastic - therapeutic use ; Cytarabine - administration & dosage ; Cytarabine - pharmacology ; Cytarabine - therapeutic use ; Etoposide - administration & dosage ; Etoposide - pharmacology ; Etoposide - therapeutic use ; Female ; Hematopoietic Stem Cell Mobilization - methods ; Hematopoietic Stem Cell Transplantation - methods ; Humans ; Lymphoma, Large B-Cell, Diffuse - drug therapy ; Lymphoma, Large B-Cell, Diffuse - pathology ; Male ; Middle Aged ; Retrospective Studies ; Transplantation Conditioning - methods ; Transplantation, Autologous - methods</subject><ispartof>Japanese journal of clinical oncology, 2017-09, Vol.47 (9), p.820-825</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-ca704c97b3b2c9201b7e02c3c02d3e6bfa301b10c11a4494cc51cd87e60a51bd3</citedby><cites>FETCH-LOGICAL-c350t-ca704c97b3b2c9201b7e02c3c02d3e6bfa301b10c11a4494cc51cd87e60a51bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28541555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koyama, Daisuke</creatorcontrib><creatorcontrib>Nishiwaki, Satoshi</creatorcontrib><creatorcontrib>Harada, Yasuhiko</creatorcontrib><creatorcontrib>Yamamoto, Satomi</creatorcontrib><creatorcontrib>Kurahashi, Shingo</creatorcontrib><creatorcontrib>Sugimoto, Takumi</creatorcontrib><creatorcontrib>Iwasaki, Toshihiro</creatorcontrib><creatorcontrib>Sugiura, Isamu</creatorcontrib><title>Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen).
We retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1-4) and cytarabine (100 mg/m2/day, days 1-4)] at Toyohashi municipal hospital from 2004 to 2013.
The median age of the patients was 55 years. The most common underlying diseases were diffuse large B-cell lymphoma (46%) and follicular lymphoma (26%). Three-quarters of patients were in their second complete or partial remission. The median total number of collected CD34+ cells was 10.6 × 106 kg-1. Forty-two patients (91%) yielded at least 2 × 106 kg-1 CD34+ cells within a median of 2 apheresis days, and 33 patients (72%) achieved it with only one apheresis. Successful mobilization was observed in five of six patients who failed to mobilize previously. Although febrile neutropenia occurred in 22 patients (48%), no fatal infection was observed.
The EC regimen was highly effective in lymphoma patients, including patients who mobilized poorly with other regimens.</description><subject>Adolescent</subject><subject>Antimetabolites, Antineoplastic - administration & dosage</subject><subject>Antimetabolites, Antineoplastic - pharmacology</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Cytarabine - administration & dosage</subject><subject>Cytarabine - pharmacology</subject><subject>Cytarabine - therapeutic use</subject><subject>Etoposide - administration & dosage</subject><subject>Etoposide - pharmacology</subject><subject>Etoposide - therapeutic use</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Mobilization - methods</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Humans</subject><subject>Lymphoma, Large B-Cell, Diffuse - drug therapy</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Transplantation Conditioning - methods</subject><subject>Transplantation, Autologous - methods</subject><issn>0368-2811</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1P3DAQhq0KVLa0p96Rj6BuwJ_56K1abSnSSlzoObInE9arJA62lzb8iv7kBhY4jWb0zPuO5iXkK2eXnFXyarcDf7Wd_rIi_0AWXOU6k7ngR2TBZF5mouT8hHyKcccY06UqPpITUWrFtdYL8m_dtgjJPSKFLfa-99Z17skk5wf6x6UtxeRHH12D1AwNhSmZYKwbkJ6vVzTgvetxuKBuoN3Uj1vfGzrO2zik-J0aGt1w32EGc49hOfMp-DgeHJfU24jh8cXMdDSmfTN9Jset6SJ-ea2n5PfP9d3qV7a5vb5Z_dhkIDVLGZiCKagKK62ASjBuC2QCJDDRSMxta-Q84ww4N0pVCkBzaMoCc2Y0t408JecH3TH4hz3GVPcuAnadGdDvY80rJlQpJFcz-u2Awnx7DNjWY3C9CVPNWf0cQf0cQX2IYKbPXoX3tsfmnX37ufwP9HmGyw</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Koyama, Daisuke</creator><creator>Nishiwaki, Satoshi</creator><creator>Harada, Yasuhiko</creator><creator>Yamamoto, Satomi</creator><creator>Kurahashi, Shingo</creator><creator>Sugimoto, Takumi</creator><creator>Iwasaki, Toshihiro</creator><creator>Sugiura, Isamu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study</title><author>Koyama, Daisuke ; Nishiwaki, Satoshi ; Harada, Yasuhiko ; Yamamoto, Satomi ; Kurahashi, Shingo ; Sugimoto, Takumi ; Iwasaki, Toshihiro ; Sugiura, Isamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-ca704c97b3b2c9201b7e02c3c02d3e6bfa301b10c11a4494cc51cd87e60a51bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Antimetabolites, Antineoplastic - administration & dosage</topic><topic>Antimetabolites, Antineoplastic - pharmacology</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>Cytarabine - administration & dosage</topic><topic>Cytarabine - pharmacology</topic><topic>Cytarabine - therapeutic use</topic><topic>Etoposide - administration & dosage</topic><topic>Etoposide - pharmacology</topic><topic>Etoposide - therapeutic use</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Mobilization - methods</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Humans</topic><topic>Lymphoma, Large B-Cell, Diffuse - drug therapy</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Transplantation Conditioning - methods</topic><topic>Transplantation, Autologous - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koyama, Daisuke</creatorcontrib><creatorcontrib>Nishiwaki, Satoshi</creatorcontrib><creatorcontrib>Harada, Yasuhiko</creatorcontrib><creatorcontrib>Yamamoto, Satomi</creatorcontrib><creatorcontrib>Kurahashi, Shingo</creatorcontrib><creatorcontrib>Sugimoto, Takumi</creatorcontrib><creatorcontrib>Iwasaki, Toshihiro</creatorcontrib><creatorcontrib>Sugiura, Isamu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koyama, Daisuke</au><au>Nishiwaki, Satoshi</au><au>Harada, Yasuhiko</au><au>Yamamoto, Satomi</au><au>Kurahashi, Shingo</au><au>Sugimoto, Takumi</au><au>Iwasaki, Toshihiro</au><au>Sugiura, Isamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>Jpn J Clin Oncol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>47</volume><issue>9</issue><spage>820</spage><epage>825</epage><pages>820-825</pages><issn>0368-2811</issn><eissn>1465-3621</eissn><abstract>Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen).
We retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1-4) and cytarabine (100 mg/m2/day, days 1-4)] at Toyohashi municipal hospital from 2004 to 2013.
The median age of the patients was 55 years. The most common underlying diseases were diffuse large B-cell lymphoma (46%) and follicular lymphoma (26%). Three-quarters of patients were in their second complete or partial remission. The median total number of collected CD34+ cells was 10.6 × 106 kg-1. Forty-two patients (91%) yielded at least 2 × 106 kg-1 CD34+ cells within a median of 2 apheresis days, and 33 patients (72%) achieved it with only one apheresis. Successful mobilization was observed in five of six patients who failed to mobilize previously. Although febrile neutropenia occurred in 22 patients (48%), no fatal infection was observed.
The EC regimen was highly effective in lymphoma patients, including patients who mobilized poorly with other regimens.</abstract><cop>England</cop><pmid>28541555</pmid><doi>10.1093/jjco/hyx076</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2811 |
| ispartof | Japanese journal of clinical oncology, 2017-09, Vol.47 (9), p.820-825 |
| issn | 0368-2811 1465-3621 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1902482314 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Cytarabine - administration & dosage Cytarabine - pharmacology Cytarabine - therapeutic use Etoposide - administration & dosage Etoposide - pharmacology Etoposide - therapeutic use Female Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cell Transplantation - methods Humans Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - pathology Male Middle Aged Retrospective Studies Transplantation Conditioning - methods Transplantation, Autologous - methods |
| title | Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T02%3A27%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effective%20chemomobilization%20with%20etoposide%20and%20cytarabine%20(EC%20regimen)%20in%20lymphoma%20patients:%20a%20single-center,%20retrospective,%20observational%20study&rft.jtitle=Japanese%20journal%20of%20clinical%20oncology&rft.au=Koyama,%20Daisuke&rft.date=2017-09-01&rft.volume=47&rft.issue=9&rft.spage=820&rft.epage=825&rft.pages=820-825&rft.issn=0368-2811&rft.eissn=1465-3621&rft_id=info:doi/10.1093/jjco/hyx076&rft_dat=%3Cproquest_cross%3E1902482314%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1902482314&rft_id=info:pmid/28541555&rfr_iscdi=true |