Length effect of methoxy poly(ethylene oxide)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] copolymers on cisplatin delivery

A novel comb-shape amphiphilic copolymer of mPEG-b-[PCL-g-pMAA] was constructed to chelate cisplatin for passive drug targeting into cancerous cells. [Display omitted] •A comb-shape amphiphilic copolymer, MPEG-PCL-pMAA, was constructed.•Zinc ethyl β-diiminate was adopted for the ROP reaction of MPCL...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2017-08, Vol.156, p.243-253
Hauptverfasser:	Chen, Hsuan-Ying, Lo, Yu-Lun, Wu, Pei-Ling, Lo, Pei-Chi, Wang, Li-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Atom transfer radical polymerization caprolactone Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cisplatin - chemistry Cisplatin - pharmacology Comb-shape amphiphilic block copolymers Dose-Response Relationship, Drug Drug Carriers - chemistry Drug Delivery Systems Drug Screening Assays, Antitumor Humans Molecular Structure Particle Size Poly(ethylene glycol) Poly(methacrylic acid) Poly(ε Polyesters - chemical synthesis Polyesters - chemistry Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Ring opening polymerization Structure-Activity Relationship
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