Length effect of methoxy poly(ethylene oxide)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] copolymers on cisplatin delivery
A novel comb-shape amphiphilic copolymer of mPEG-b-[PCL-g-pMAA] was constructed to chelate cisplatin for passive drug targeting into cancerous cells. [Display omitted] •A comb-shape amphiphilic copolymer, MPEG-PCL-pMAA, was constructed.•Zinc ethyl β-diiminate was adopted for the ROP reaction of MPCL...
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Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2017-08, Vol.156, p.243-253 |
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creator | Chen, Hsuan-Ying Lo, Yu-Lun Wu, Pei-Ling Lo, Pei-Chi Wang, Li-Fang |
description | A novel comb-shape amphiphilic copolymer of mPEG-b-[PCL-g-pMAA] was constructed to chelate cisplatin for passive drug targeting into cancerous cells.
[Display omitted]
•A comb-shape amphiphilic copolymer, MPEG-PCL-pMAA, was constructed.•Zinc ethyl β-diiminate was adopted for the ROP reaction of MPCL-Br.•MPEG-PCL-pMAA particles were utilized to coordinate cisplatin for chemotherapy.•MPEG-PCL-pMAA particles can be utilized to a co-delivery system of two drugs.
Novel comb-shaped amphiphilic copolymers based on methoxy poly(ethylene glycol)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] (MPCL-g-pMAA), were synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) for drug delivery systems. MPCL-g-pMAAs with various MAA repeating units self-assemble into a core-shell structure in an aqueous solution. Critical aggregation concentrations range within 5.6×10−3–7.0×10−2mg/mL in double deionized water and 8.9×10−3–7.0×10−2mg/mL in phosphate buffered saline of pH 7.4, decreasing with increase in pMAA length. The carboxylic groups of MPCL-g-pMAAs were utilized to coordinate cisplatin, forming polymer-metal complexes for chemotherapy. The average hydrodynamic diameters of particles are within 220–246nm, slightly dependent on pMAA length. However, the cisplatin-loaded MPCL-g-pMAAs particles have average hydrodynamic diameters of 263–412nm owing to increasing drug loading efficiency with increase in pMAA length. Nevertheless, the MPCL-g-pMAA with the least number of MAA repeating unit shows the fastest drug release rate as well as the highest cytotoxicity against CRL-5802 cells. The cellular uptake of MPCL-g-pMAA particles, involving mainly clathrin-mediated endocytosis, increases with incubation time. MPCL-g-pMAA particles are non-cytotoxic to CRL-5802 cells but the cisplatin-loaded MPCL-g-pMAA particles show profound cell-killing ability. The MPCL-g-pMAA is a potential carrier for drug delivery systems. |
doi_str_mv | 10.1016/j.colsurfb.2017.05.034 |
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[Display omitted]
•A comb-shape amphiphilic copolymer, MPEG-PCL-pMAA, was constructed.•Zinc ethyl β-diiminate was adopted for the ROP reaction of MPCL-Br.•MPEG-PCL-pMAA particles were utilized to coordinate cisplatin for chemotherapy.•MPEG-PCL-pMAA particles can be utilized to a co-delivery system of two drugs.
Novel comb-shaped amphiphilic copolymers based on methoxy poly(ethylene glycol)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] (MPCL-g-pMAA), were synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) for drug delivery systems. MPCL-g-pMAAs with various MAA repeating units self-assemble into a core-shell structure in an aqueous solution. Critical aggregation concentrations range within 5.6×10−3–7.0×10−2mg/mL in double deionized water and 8.9×10−3–7.0×10−2mg/mL in phosphate buffered saline of pH 7.4, decreasing with increase in pMAA length. The carboxylic groups of MPCL-g-pMAAs were utilized to coordinate cisplatin, forming polymer-metal complexes for chemotherapy. The average hydrodynamic diameters of particles are within 220–246nm, slightly dependent on pMAA length. However, the cisplatin-loaded MPCL-g-pMAAs particles have average hydrodynamic diameters of 263–412nm owing to increasing drug loading efficiency with increase in pMAA length. Nevertheless, the MPCL-g-pMAA with the least number of MAA repeating unit shows the fastest drug release rate as well as the highest cytotoxicity against CRL-5802 cells. The cellular uptake of MPCL-g-pMAA particles, involving mainly clathrin-mediated endocytosis, increases with incubation time. MPCL-g-pMAA particles are non-cytotoxic to CRL-5802 cells but the cisplatin-loaded MPCL-g-pMAA particles show profound cell-killing ability. The MPCL-g-pMAA is a potential carrier for drug delivery systems.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2017.05.034</identifier><identifier>PMID: 28535473</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Atom transfer radical polymerization ; caprolactone ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cisplatin - chemistry ; Cisplatin - pharmacology ; Comb-shape amphiphilic block copolymers ; Dose-Response Relationship, Drug ; Drug Carriers - chemistry ; Drug Delivery Systems ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Particle Size ; Poly(ethylene glycol) ; Poly(methacrylic acid) ; Poly(ε ; Polyesters - chemical synthesis ; Polyesters - chemistry ; Polyethylene Glycols - chemical synthesis ; Polyethylene Glycols - chemistry ; Ring opening polymerization ; Structure-Activity Relationship</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2017-08, Vol.156, p.243-253</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-af644ffb5e0990ca99195ff858682848dff9dc3a376901d60924f1978ebaa8d43</citedby><cites>FETCH-LOGICAL-c471t-af644ffb5e0990ca99195ff858682848dff9dc3a376901d60924f1978ebaa8d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2017.05.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28535473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hsuan-Ying</creatorcontrib><creatorcontrib>Lo, Yu-Lun</creatorcontrib><creatorcontrib>Wu, Pei-Ling</creatorcontrib><creatorcontrib>Lo, Pei-Chi</creatorcontrib><creatorcontrib>Wang, Li-Fang</creatorcontrib><title>Length effect of methoxy poly(ethylene oxide)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] copolymers on cisplatin delivery</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>A novel comb-shape amphiphilic copolymer of mPEG-b-[PCL-g-pMAA] was constructed to chelate cisplatin for passive drug targeting into cancerous cells.
[Display omitted]
•A comb-shape amphiphilic copolymer, MPEG-PCL-pMAA, was constructed.•Zinc ethyl β-diiminate was adopted for the ROP reaction of MPCL-Br.•MPEG-PCL-pMAA particles were utilized to coordinate cisplatin for chemotherapy.•MPEG-PCL-pMAA particles can be utilized to a co-delivery system of two drugs.
Novel comb-shaped amphiphilic copolymers based on methoxy poly(ethylene glycol)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] (MPCL-g-pMAA), were synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) for drug delivery systems. MPCL-g-pMAAs with various MAA repeating units self-assemble into a core-shell structure in an aqueous solution. Critical aggregation concentrations range within 5.6×10−3–7.0×10−2mg/mL in double deionized water and 8.9×10−3–7.0×10−2mg/mL in phosphate buffered saline of pH 7.4, decreasing with increase in pMAA length. The carboxylic groups of MPCL-g-pMAAs were utilized to coordinate cisplatin, forming polymer-metal complexes for chemotherapy. The average hydrodynamic diameters of particles are within 220–246nm, slightly dependent on pMAA length. However, the cisplatin-loaded MPCL-g-pMAAs particles have average hydrodynamic diameters of 263–412nm owing to increasing drug loading efficiency with increase in pMAA length. Nevertheless, the MPCL-g-pMAA with the least number of MAA repeating unit shows the fastest drug release rate as well as the highest cytotoxicity against CRL-5802 cells. The cellular uptake of MPCL-g-pMAA particles, involving mainly clathrin-mediated endocytosis, increases with incubation time. MPCL-g-pMAA particles are non-cytotoxic to CRL-5802 cells but the cisplatin-loaded MPCL-g-pMAA particles show profound cell-killing ability. The MPCL-g-pMAA is a potential carrier for drug delivery systems.</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Atom transfer radical polymerization</subject><subject>caprolactone</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cisplatin - chemistry</subject><subject>Cisplatin - pharmacology</subject><subject>Comb-shape amphiphilic block copolymers</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Humans</subject><subject>Molecular Structure</subject><subject>Particle Size</subject><subject>Poly(ethylene glycol)</subject><subject>Poly(methacrylic acid)</subject><subject>Poly(ε</subject><subject>Polyesters - chemical synthesis</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene Glycols - chemical synthesis</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Ring opening polymerization</subject><subject>Structure-Activity Relationship</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9O3DAQxq2qqCy0r4B8hENSO3Fi-9YK0VJppV7oqaosxx6DV068tbOIHPtQvAbPVC8LvfY0o5nvmz8_hM4oqSmh_cdNbWLIu-SGuiGU16SrScveoBUVvK1Y2_O3aEVkwyvO--4YneS8IYQ0jPJ36LgRXdsx3q7QnzVMt_MdBufAzDg6PMJ8Fx8WvI1hOS_5EmACHB-8hYtqqH4-158eK6O3KQZt5jiVxm31XN-btUlL8AZr4-3FL2zivjNCyjhO2Pi8DXr2E7YQ_D2k5T06cjpk-PAST9GPL1c3l9fV-vvXb5ef15VhnM6Vdj1jzg0dECmJ0VJS2TknOtGLRjBhnZPWtLrlvSTU9uV35qjkAgathWXtKTo_zC1n_95BntXos4EQ9ARxlxWVpKGkbxtRpP1BalLMOYFT2-RHnRZFidrjVxv1il_t8SvSqYK_GM9eduyGEew_2yvvIvh0EED59N5DUtl4mAxYnwp_ZaP_346_8imdKg</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Chen, Hsuan-Ying</creator><creator>Lo, Yu-Lun</creator><creator>Wu, Pei-Ling</creator><creator>Lo, Pei-Chi</creator><creator>Wang, Li-Fang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Length effect of methoxy poly(ethylene oxide)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] copolymers on cisplatin delivery</title><author>Chen, Hsuan-Ying ; Lo, Yu-Lun ; Wu, Pei-Ling ; Lo, Pei-Chi ; Wang, Li-Fang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-af644ffb5e0990ca99195ff858682848dff9dc3a376901d60924f1978ebaa8d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Atom transfer radical polymerization</topic><topic>caprolactone</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cisplatin - chemistry</topic><topic>Cisplatin - pharmacology</topic><topic>Comb-shape amphiphilic block copolymers</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Humans</topic><topic>Molecular Structure</topic><topic>Particle Size</topic><topic>Poly(ethylene glycol)</topic><topic>Poly(methacrylic acid)</topic><topic>Poly(ε</topic><topic>Polyesters - chemical synthesis</topic><topic>Polyesters - chemistry</topic><topic>Polyethylene Glycols - chemical synthesis</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Ring opening polymerization</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hsuan-Ying</creatorcontrib><creatorcontrib>Lo, Yu-Lun</creatorcontrib><creatorcontrib>Wu, Pei-Ling</creatorcontrib><creatorcontrib>Lo, Pei-Chi</creatorcontrib><creatorcontrib>Wang, Li-Fang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hsuan-Ying</au><au>Lo, Yu-Lun</au><au>Wu, Pei-Ling</au><au>Lo, Pei-Chi</au><au>Wang, Li-Fang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Length effect of methoxy poly(ethylene oxide)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] copolymers on cisplatin delivery</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>156</volume><spage>243</spage><epage>253</epage><pages>243-253</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>A novel comb-shape amphiphilic copolymer of mPEG-b-[PCL-g-pMAA] was constructed to chelate cisplatin for passive drug targeting into cancerous cells.
[Display omitted]
•A comb-shape amphiphilic copolymer, MPEG-PCL-pMAA, was constructed.•Zinc ethyl β-diiminate was adopted for the ROP reaction of MPCL-Br.•MPEG-PCL-pMAA particles were utilized to coordinate cisplatin for chemotherapy.•MPEG-PCL-pMAA particles can be utilized to a co-delivery system of two drugs.
Novel comb-shaped amphiphilic copolymers based on methoxy poly(ethylene glycol)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] (MPCL-g-pMAA), were synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) for drug delivery systems. MPCL-g-pMAAs with various MAA repeating units self-assemble into a core-shell structure in an aqueous solution. Critical aggregation concentrations range within 5.6×10−3–7.0×10−2mg/mL in double deionized water and 8.9×10−3–7.0×10−2mg/mL in phosphate buffered saline of pH 7.4, decreasing with increase in pMAA length. The carboxylic groups of MPCL-g-pMAAs were utilized to coordinate cisplatin, forming polymer-metal complexes for chemotherapy. The average hydrodynamic diameters of particles are within 220–246nm, slightly dependent on pMAA length. However, the cisplatin-loaded MPCL-g-pMAAs particles have average hydrodynamic diameters of 263–412nm owing to increasing drug loading efficiency with increase in pMAA length. Nevertheless, the MPCL-g-pMAA with the least number of MAA repeating unit shows the fastest drug release rate as well as the highest cytotoxicity against CRL-5802 cells. The cellular uptake of MPCL-g-pMAA particles, involving mainly clathrin-mediated endocytosis, increases with incubation time. MPCL-g-pMAA particles are non-cytotoxic to CRL-5802 cells but the cisplatin-loaded MPCL-g-pMAA particles show profound cell-killing ability. The MPCL-g-pMAA is a potential carrier for drug delivery systems.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28535473</pmid><doi>10.1016/j.colsurfb.2017.05.034</doi><tpages>11</tpages></addata></record> |
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subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Atom transfer radical polymerization caprolactone Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cisplatin - chemistry Cisplatin - pharmacology Comb-shape amphiphilic block copolymers Dose-Response Relationship, Drug Drug Carriers - chemistry Drug Delivery Systems Drug Screening Assays, Antitumor Humans Molecular Structure Particle Size Poly(ethylene glycol) Poly(methacrylic acid) Poly(ε Polyesters - chemical synthesis Polyesters - chemistry Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Ring opening polymerization Structure-Activity Relationship |
title | Length effect of methoxy poly(ethylene oxide)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] copolymers on cisplatin delivery |
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