Circulating miRNAs from imprinted genomic regions are associated with peripheral muscle strength in COPD patients
Reduced muscle mass and strength are common comorbidities of COPD that lead to a poorer quality of life and are associated with increased mortality. Whilst the presence of disease may be viewed as a ‘necessary’ factor for the loss of muscle mass and strength, disease severity itself is not tightly l...
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| Veröffentlicht in: | The European respiratory journal 2017-04, Vol.49 (4), p.1601881-1601881 |
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| container_end_page | 1601881 |
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| container_issue | 4 |
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| container_title | The European respiratory journal |
| container_volume | 49 |
| creator | Lee, Jen Y Donaldson, Anna V Lewis, Amy Natanek, S Amanda Polkey, Michael I Kemp, Paul R |
| description | Reduced muscle mass and strength are common comorbidities of COPD that lead to a poorer quality of life and are associated with increased mortality. Whilst the presence of disease may be viewed as a ‘necessary’ factor for the loss of muscle mass and strength, disease severity itself is not tightly linked to muscle loss, as some patients with mild disease have a significant loss of muscle mass and strength, whereas others with severe disease appear to maintain a normal muscle mass and strength [1]. These differences in susceptibility to changes in muscle are likely to be caused by the interplay between genetic, epigenetic and environmental factors. |
| doi_str_mv | 10.1183/13993003.01881-2016 |
| format | Article |
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These differences in susceptibility to changes in muscle are likely to be caused by the interplay between genetic, epigenetic and environmental factors.</description><subject>Chronic obstructive pulmonary disease</subject><subject>Circulating MicroRNA - blood</subject><subject>DNA Methylation</subject><subject>Environmental factors</subject><subject>Female</subject><subject>Genomic Imprinting</subject><subject>Humans</subject><subject>Male</subject><subject>Muscle Strength</subject><subject>Muscle Weakness - blood</subject><subject>Muscle Weakness - etiology</subject><subject>Pulmonary Disease, Chronic Obstructive - blood</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Quality of life</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1KxDAQx4Mo7rr6BIIEvHjpmmn6kRyX9RPEFdFzSdNkjbRpTVrEt_FZfDJTXT148RSY-c0_zPwQOgQyB2D0FCjnlBA6J8AYRDGBbAtNx2o0lrfRlHBCI-A0m6A9759JIBIKu2gSsyTJ0jSfIrc0Tg616I1d48bc3y481q5tsGk6Z2yvKrxWtm2MxE6tTWs9Fk5h4X0rjRjbr6Z_wp1ypntSTtS4GbysFfa9U3YdWsbi5eru7OO9C58o2_t9tKNF7dXB5p2hx4vzh-VVdLO6vF4ubiKZAPRRHBOWp7kqy1TLTEKiK1lxBkwzkuR5RqSkWcWIkKVOBRAqQTCqOZQ6EyAZnaGT79zOtS-D8n3RGC9VXQur2sEXwAnkWQxp-j_KeJzHNA0Hn6HjP-hzOzgbFgmBjPKYM5YHin5T0rXeO6WLcM1GuLcCSDHaK37sFV_2itFemDraZA9lo6rfmR9d9BMfP5YL</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Lee, Jen Y</creator><creator>Donaldson, Anna V</creator><creator>Lewis, Amy</creator><creator>Natanek, S Amanda</creator><creator>Polkey, Michael I</creator><creator>Kemp, Paul R</creator><general>European Respiratory Society Journals Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8975-7293</orcidid></search><sort><creationdate>20170401</creationdate><title>Circulating miRNAs from imprinted genomic regions are associated with peripheral muscle strength in COPD patients</title><author>Lee, Jen Y ; Donaldson, Anna V ; Lewis, Amy ; Natanek, S Amanda ; Polkey, Michael I ; Kemp, Paul R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-2208757ebb5fc6c14fdcd9818f8047760cc36d80acbf5a103c1a83f91bf6a1c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Chronic obstructive pulmonary disease</topic><topic>Circulating MicroRNA - blood</topic><topic>DNA Methylation</topic><topic>Environmental factors</topic><topic>Female</topic><topic>Genomic Imprinting</topic><topic>Humans</topic><topic>Male</topic><topic>Muscle Strength</topic><topic>Muscle Weakness - blood</topic><topic>Muscle Weakness - etiology</topic><topic>Pulmonary Disease, Chronic Obstructive - blood</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Quality of life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jen Y</creatorcontrib><creatorcontrib>Donaldson, Anna V</creatorcontrib><creatorcontrib>Lewis, Amy</creatorcontrib><creatorcontrib>Natanek, S Amanda</creatorcontrib><creatorcontrib>Polkey, Michael I</creatorcontrib><creatorcontrib>Kemp, Paul R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jen Y</au><au>Donaldson, Anna V</au><au>Lewis, Amy</au><au>Natanek, S Amanda</au><au>Polkey, Michael I</au><au>Kemp, Paul R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating miRNAs from imprinted genomic regions are associated with peripheral muscle strength in COPD patients</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>49</volume><issue>4</issue><spage>1601881</spage><epage>1601881</epage><pages>1601881-1601881</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Reduced muscle mass and strength are common comorbidities of COPD that lead to a poorer quality of life and are associated with increased mortality. 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| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 2017-04, Vol.49 (4), p.1601881-1601881 |
| issn | 0903-1936 1399-3003 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Chronic obstructive pulmonary disease Circulating MicroRNA - blood DNA Methylation Environmental factors Female Genomic Imprinting Humans Male Muscle Strength Muscle Weakness - blood Muscle Weakness - etiology Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - physiopathology Quality of life |
| title | Circulating miRNAs from imprinted genomic regions are associated with peripheral muscle strength in COPD patients |
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