Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells

The long non-coding RNA, HOTTIP, has an important role in tumorigenesis. It is known that HOTTIP regulates HOX gene family; however, its regulatory mechanism in esophageal squamous cell carcinoma (ESCC) remains elusive. In this study, we investigated the role of HOTTIP in ESCC and observed that HOTT...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2017-09, Vol.36 (38), p.5392-5406
Hauptverfasser:	Lin, C, Wang, Y, Zhang, S, Yu, L, Guo, C, Xu, H
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/31 13/95 14/1 38/22 38/77 38/89 38/90 631/337/505 631/67/68 82/29 Animals Apoptosis Binding sites Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Care and treatment Cell Biology Cell Line, Tumor Cell proliferation Cell Proliferation - physiology Cell Transformation, Neoplastic Cytoplasm Development and progression Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Esophagus Female Gene expression Gene Expression Regulation, Neoplastic Gene regulation Genetic aspects Health aspects Heterografts Histone H3 Histones Homeodomain Proteins - genetics Homeodomain Proteins - metabolism HOX gene Hoxa13 gene Human Genetics Humans Internal Medicine Lysine Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Mice Mice, Inbred BALB C Neoplasm Metastasis Non-coding RNA Nuclei Oncology original-article Post-transcription Protein Processing, Post-Translational RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Squamous cell carcinoma Therapeutic targets Transcription Transcription factors Transcription, Genetic Tumorigenesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!