Novel strategies for the formulation and processing of poorly water-soluble drugs
[Display omitted] Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on st...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2018-05, Vol.126, p.40-56 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
| container_volume | 126 |
| creator | Göke, Katrin Lorenz, Thomas Repanas, Alexandros Schneider, Frederic Steiner, Denise Baumann, Knut Bunjes, Heike Dietzel, Andreas Finke, Jan H. Glasmacher, Birgit Kwade, Arno |
| description | [Display omitted]
Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers. |
| doi_str_mv | 10.1016/j.ejpb.2017.05.008 |
| format | Article |
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Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2017.05.008</identifier><identifier>PMID: 28532676</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Colloidal lipid carriers ; Computational carrier selection ; Drug delivery systems ; Drug nanosuspensions ; Electrospinning ; Microfluidics ; Orodispersible films ; Solubility</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2018-05, Vol.126, p.40-56</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-e7afe42e883125164d36b1b02625a05fa3c932f6c08c11ec3b14f6952c7fae423</citedby><cites>FETCH-LOGICAL-c422t-e7afe42e883125164d36b1b02625a05fa3c932f6c08c11ec3b14f6952c7fae423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S093964111730156X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28532676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Göke, Katrin</creatorcontrib><creatorcontrib>Lorenz, Thomas</creatorcontrib><creatorcontrib>Repanas, Alexandros</creatorcontrib><creatorcontrib>Schneider, Frederic</creatorcontrib><creatorcontrib>Steiner, Denise</creatorcontrib><creatorcontrib>Baumann, Knut</creatorcontrib><creatorcontrib>Bunjes, Heike</creatorcontrib><creatorcontrib>Dietzel, Andreas</creatorcontrib><creatorcontrib>Finke, Jan H.</creatorcontrib><creatorcontrib>Glasmacher, Birgit</creatorcontrib><creatorcontrib>Kwade, Arno</creatorcontrib><title>Novel strategies for the formulation and processing of poorly water-soluble drugs</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>[Display omitted]
Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers.</description><subject>Colloidal lipid carriers</subject><subject>Computational carrier selection</subject><subject>Drug delivery systems</subject><subject>Drug nanosuspensions</subject><subject>Electrospinning</subject><subject>Microfluidics</subject><subject>Orodispersible films</subject><subject>Solubility</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMoOj7-gAvJ0k1rHk3aghsZfMGgCLoOaXozZug0NWkV_70ZZnTp6my-c7j3Q-ickpwSKq9WOayGJmeEljkROSHVHprRquQZLwq6j2ak5nUmC0qP0HGMK0JIUYrqEB2xSnAmSzlDL0_-Ezocx6BHWDqI2PqAx3fY5Hrq9Oh8j3Xf4iF4AzG6fom9xYP3ofvGX6kVsui7qekAt2FaxlN0YHUX4WyXJ-jt7vZ1_pAtnu8f5zeLzBSMjRmU2kLBoKo4ZYLKouWyoQ1hkglNhNXc1JxZaUhlKAXDG1pYWQtmSqtTkZ-gy-1uOuxjgjiqtYsGuk734KeoaJ28CFYxklC2RU3wMQawaghurcO3okRtVKqV2qhUG5WKCJVUptLFbn9q1tD-VX7dJeB6C0D68tNBUNE46A20LoAZVevdf_s_x1qFcQ</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Göke, Katrin</creator><creator>Lorenz, Thomas</creator><creator>Repanas, Alexandros</creator><creator>Schneider, Frederic</creator><creator>Steiner, Denise</creator><creator>Baumann, Knut</creator><creator>Bunjes, Heike</creator><creator>Dietzel, Andreas</creator><creator>Finke, Jan H.</creator><creator>Glasmacher, Birgit</creator><creator>Kwade, Arno</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Novel strategies for the formulation and processing of poorly water-soluble drugs</title><author>Göke, Katrin ; Lorenz, Thomas ; Repanas, Alexandros ; Schneider, Frederic ; Steiner, Denise ; Baumann, Knut ; Bunjes, Heike ; Dietzel, Andreas ; Finke, Jan H. ; Glasmacher, Birgit ; Kwade, Arno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-e7afe42e883125164d36b1b02625a05fa3c932f6c08c11ec3b14f6952c7fae423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Colloidal lipid carriers</topic><topic>Computational carrier selection</topic><topic>Drug delivery systems</topic><topic>Drug nanosuspensions</topic><topic>Electrospinning</topic><topic>Microfluidics</topic><topic>Orodispersible films</topic><topic>Solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Göke, Katrin</creatorcontrib><creatorcontrib>Lorenz, Thomas</creatorcontrib><creatorcontrib>Repanas, Alexandros</creatorcontrib><creatorcontrib>Schneider, Frederic</creatorcontrib><creatorcontrib>Steiner, Denise</creatorcontrib><creatorcontrib>Baumann, Knut</creatorcontrib><creatorcontrib>Bunjes, Heike</creatorcontrib><creatorcontrib>Dietzel, Andreas</creatorcontrib><creatorcontrib>Finke, Jan H.</creatorcontrib><creatorcontrib>Glasmacher, Birgit</creatorcontrib><creatorcontrib>Kwade, Arno</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Göke, Katrin</au><au>Lorenz, Thomas</au><au>Repanas, Alexandros</au><au>Schneider, Frederic</au><au>Steiner, Denise</au><au>Baumann, Knut</au><au>Bunjes, Heike</au><au>Dietzel, Andreas</au><au>Finke, Jan H.</au><au>Glasmacher, Birgit</au><au>Kwade, Arno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel strategies for the formulation and processing of poorly water-soluble drugs</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2018-05</date><risdate>2018</risdate><volume>126</volume><spage>40</spage><epage>56</epage><pages>40-56</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>[Display omitted]
Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28532676</pmid><doi>10.1016/j.ejpb.2017.05.008</doi><tpages>17</tpages></addata></record> |
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| identifier | ISSN: 0939-6411 |
| ispartof | European journal of pharmaceutics and biopharmaceutics, 2018-05, Vol.126, p.40-56 |
| issn | 0939-6411 1873-3441 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Colloidal lipid carriers Computational carrier selection Drug delivery systems Drug nanosuspensions Electrospinning Microfluidics Orodispersible films Solubility |
| title | Novel strategies for the formulation and processing of poorly water-soluble drugs |
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