miR-34a knockout attenuates cognitive deficits in APP/PS1 mice through inhibition of the amyloidogenic processing of APP

The noncoding miRNA-34a (miR-34a) is involved in Alzheimer's disease (AD) pathologenesis and shows potential for application as a biomarker for early diagnosis and intervention. Here, we established miR-34a knockout mice in an APP/PS1 background (APP/PS1-miR-34a KO mice) by crossbreeding miR-34...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Life sciences (1973) 2017-08, Vol.182, p.104-111
Hauptverfasser:	Jian, Chongdong, Lu, Mengru, Zhang, Zhao, Liu, Long, Li, Xianfeng, Huang, Fang, Xu, Ning, Qin, Lina, Zhang, Qian, Zou, Donghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alzheimer Disease - genetics Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Amyloid Precursor Protein Secretases - metabolism Amyloidogenesis Amyloidogenic processing Animals Biomarkers Cognition Cognition Disorders - physiopathology Cognitive ability Disease Models, Animal Disease Progression Inhibition (psychology) Intervention Mental depression Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs MicroRNAs - genetics miR-34a miRNA Neurodegenerative diseases Pathology Presenilin 1 Rodents Secretase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!