Polymorphisms in pfdhfr and pfdhps genes after five years of artemisinin combination therapy (ACT) implementation from urban Kolkata, India

In India, sulphadoxine-pyrimethamine (SP) is now in use as a partner drug of ACT (AS+SP) to treat uncomplicated falciparum malaria since 2010. Declined trend of AS+SP efficacy has been reported from north-eastern states of the country. It is not possible to determine the efficacy of SP alone from an...

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Veröffentlicht in:	Infection, genetics and evolution genetics and evolution, 2017-09, Vol.53, p.155-159
Hauptverfasser:	Chatterjee, Moytrey, Ganguly, Swagata, Saha, Pabitra, Guha, Subhasish K., Maji, Ardhendu Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	ACT Adult Antimalarials - therapeutic use Artemisinins - therapeutic use Child Cities Dihydropteroate Synthase - genetics Dihydropteroate Synthase - metabolism Drug Combinations Drug Resistance - genetics Drug Therapy, Combination Female Gene Expression Genotype Humans India Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Male Mutation P. falciparum Pfdhfr Pfdhps Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Polymorphism, Genetic Protozoan Proteins - genetics Protozoan Proteins - metabolism Pyrimethamine - therapeutic use Retrospective Studies Sulfadoxine - therapeutic use Tetrahydrofolate Dehydrogenase - genetics Tetrahydrofolate Dehydrogenase - metabolism
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