Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology

Collection of cell-free DNA (cfDNA) from the blood of individuals with cancer has permitted noninvasive tumor genome analysis. Detection and characterization of cfDNA in ascites and pleural effusions have not yet been reported. Herein, we analyzed cfDNA in the ascites and pleural effusions from six...

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Veröffentlicht in:	Molecular cancer therapeutics 2017-05, Vol.16 (5), p.948-955
Hauptverfasser:	Husain, Hatim, Nykin, David, Bui, Nam, Quan, Daniel, Gomez, German, Woodward, Brian, Venkatapathy, Sumathi, Duttagupta, Radha, Fung, Eric, Lippman, Scott M, Kurzrock, Razelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adult Aged Aged, 80 and over Amplification Ascites Ascites - blood Ascites - genetics Ascitic fluid Biology Biopsy Blood Breast cancer Cancer Cell Line, Tumor Cell-Free Nucleic Acids - blood Cell-Free Nucleic Acids - genetics Chromosome rearrangements Class I Phosphatidylinositol 3-Kinases - genetics Copy number Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 4 - genetics Cytology Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics Epidermal growth factor receptors Female Genome, Human - genetics Genomes Humans Lung cancer Male MDM2 protein Metastases Metastasis Middle Aged Mutation Neoplasms - blood Neoplasms - classification Neoplasms - genetics Neoplasms - pathology Pleural Effusion - genetics Proto-Oncogene Proteins c-mdm2 - genetics Receptor, Epidermal Growth Factor - genetics Regression analysis TOR protein
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