Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol)
Gold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic GNR system. In this work we replace the CTAB molecules with a thiolated chitos...
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| Veröffentlicht in: | Materials Science & Engineering C 2017-08, Vol.77, p.583-593 |
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| creator | Almada, M. Leal-Martínez, B.H. Hassan, N. Kogan, M.J. Burboa, M.G. Topete, A. Valdez, M.A. Juárez, J. |
| description | Gold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic GNR system. In this work we replace the CTAB molecules with a thiolated chitosan. Once chitosan coated GNRs (Chi-SH-GNR) were attained, a film of alginate (Alg-Chi-SH-GNR) or polyvinyl alcohol (PVA-Chi-SH-GNR) was deposited onto the surface of Chi-GNR by a layer-by-layer process. The photothermal conversion efficiency for the GNR systems was determined irradiating the GNRs suspended in aqua media with a CW 808nm diode laser (CNI, China). The cytotoxicity effect and the photothermal cellular damage of GNR systems were evaluated on a breast cancer cell line. Results show that polymer coats did not affect the transduction photothermal efficiency. Values around 50% were obtained for the different coated gold nanorods. The cytotoxicity of coated gold nanorods diminished significantly compared with those GNR stabilized with CTAB. The laser irradiation of cells treated with gold nanorods showed a decrease in their viability compared with the cells treated but no irradiated.
•Gold nanorods coated with the biocompatible polymers chitosan, alginate and PVA were synthesized.•The polymer coating does not affect the photothermal efficiency.•Gold nanorods coated with the polymer diminished the cytotoxicity associated with CTAB. |
| doi_str_mv | 10.1016/j.msec.2017.03.218 |
| format | Article |
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•Gold nanorods coated with the biocompatible polymers chitosan, alginate and PVA were synthesized.•The polymer coating does not affect the photothermal efficiency.•Gold nanorods coated with the polymer diminished the cytotoxicity associated with CTAB.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2017.03.218</identifier><identifier>PMID: 28532069</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alcohols ; Alginate ; Alginates ; Alginic acid ; Breast cancer ; Cell Line, Tumor ; Cells ; China ; Chitosan ; Coating ; Cytotoxicity ; Damage assessment ; Efficiency ; Glucuronic Acid ; Gold ; Gold nanorods ; Hexuronic Acids ; Humans ; Irradiation ; Materials science ; Molecules ; Nanorods ; Nanotubes ; Photothermal conversion ; Photothermal efficiency ; Polyvinyl Alcohol ; Systems analysis ; Toxicity ; Viability</subject><ispartof>Materials Science & Engineering C, 2017-08, Vol.77, p.583-593</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Aug 1, 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-b81868ea333a70f4c594c96a217ac47c4c345e4a1c84ae3ed95fdcfc4e52913c3</citedby><cites>FETCH-LOGICAL-c421t-b81868ea333a70f4c594c96a217ac47c4c345e4a1c84ae3ed95fdcfc4e52913c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2017.03.218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28532069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almada, M.</creatorcontrib><creatorcontrib>Leal-Martínez, B.H.</creatorcontrib><creatorcontrib>Hassan, N.</creatorcontrib><creatorcontrib>Kogan, M.J.</creatorcontrib><creatorcontrib>Burboa, M.G.</creatorcontrib><creatorcontrib>Topete, A.</creatorcontrib><creatorcontrib>Valdez, M.A.</creatorcontrib><creatorcontrib>Juárez, J.</creatorcontrib><title>Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol)</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Gold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic GNR system. In this work we replace the CTAB molecules with a thiolated chitosan. Once chitosan coated GNRs (Chi-SH-GNR) were attained, a film of alginate (Alg-Chi-SH-GNR) or polyvinyl alcohol (PVA-Chi-SH-GNR) was deposited onto the surface of Chi-GNR by a layer-by-layer process. The photothermal conversion efficiency for the GNR systems was determined irradiating the GNRs suspended in aqua media with a CW 808nm diode laser (CNI, China). The cytotoxicity effect and the photothermal cellular damage of GNR systems were evaluated on a breast cancer cell line. Results show that polymer coats did not affect the transduction photothermal efficiency. Values around 50% were obtained for the different coated gold nanorods. The cytotoxicity of coated gold nanorods diminished significantly compared with those GNR stabilized with CTAB. The laser irradiation of cells treated with gold nanorods showed a decrease in their viability compared with the cells treated but no irradiated.
•Gold nanorods coated with the biocompatible polymers chitosan, alginate and PVA were synthesized.•The polymer coating does not affect the photothermal efficiency.•Gold nanorods coated with the polymer diminished the cytotoxicity associated with CTAB.</description><subject>Alcohols</subject><subject>Alginate</subject><subject>Alginates</subject><subject>Alginic acid</subject><subject>Breast cancer</subject><subject>Cell Line, Tumor</subject><subject>Cells</subject><subject>China</subject><subject>Chitosan</subject><subject>Coating</subject><subject>Cytotoxicity</subject><subject>Damage assessment</subject><subject>Efficiency</subject><subject>Glucuronic Acid</subject><subject>Gold</subject><subject>Gold nanorods</subject><subject>Hexuronic Acids</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Materials science</subject><subject>Molecules</subject><subject>Nanorods</subject><subject>Nanotubes</subject><subject>Photothermal conversion</subject><subject>Photothermal efficiency</subject><subject>Polyvinyl Alcohol</subject><subject>Systems analysis</subject><subject>Toxicity</subject><subject>Viability</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2r1DAUhoso3vHqH3AhATdXsDVfbVNwIxe_4IIudB0yp6e3GdJkTDqjdesfN525unDhKnDynJfD-xTFU0YrRlnzaldNCaHilLUVFRVn6l6xYaoVJWUdu19saMdVKTvBLopHKe0obZRo-cPigqtacNp0m-LX5zHMYR4xTsYRCP6IMdngCQ6DBYseFmJ8T2DJVPhhYf1AmEkYyG1wPfHGhxj6RNJsttbZn9iT73YeCYx2Dsn4l8S4W-vNjKegfXDL1dH6xeU5hDG4F4-LB4NxCZ_cvZfF13dvv1x_KG8-vf94_eamBMnZXG4VU41CI4QwLR0k1J2ErjGctQZkCxKErFEaBkoaFNh39dDDABJr3jEB4rK4OufuY_h2wDTrySZA54zHcEiadbnJei0wo8__QXfhEH2-LlOStzyXrjLFzxTEkFLEQe-jnUxcNKN6VaR3elWkV0WaCs1PS8_uog_bCfu_K3-cZOD1GcDcxdFi1OkkAnsbc_O6D_Z_-b8BmsKkqA</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Almada, M.</creator><creator>Leal-Martínez, B.H.</creator><creator>Hassan, N.</creator><creator>Kogan, M.J.</creator><creator>Burboa, M.G.</creator><creator>Topete, A.</creator><creator>Valdez, M.A.</creator><creator>Juárez, J.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol)</title><author>Almada, M. ; Leal-Martínez, B.H. ; Hassan, N. ; Kogan, M.J. ; Burboa, M.G. ; Topete, A. ; Valdez, M.A. ; Juárez, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-b81868ea333a70f4c594c96a217ac47c4c345e4a1c84ae3ed95fdcfc4e52913c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alcohols</topic><topic>Alginate</topic><topic>Alginates</topic><topic>Alginic acid</topic><topic>Breast cancer</topic><topic>Cell Line, Tumor</topic><topic>Cells</topic><topic>China</topic><topic>Chitosan</topic><topic>Coating</topic><topic>Cytotoxicity</topic><topic>Damage assessment</topic><topic>Efficiency</topic><topic>Glucuronic Acid</topic><topic>Gold</topic><topic>Gold nanorods</topic><topic>Hexuronic Acids</topic><topic>Humans</topic><topic>Irradiation</topic><topic>Materials science</topic><topic>Molecules</topic><topic>Nanorods</topic><topic>Nanotubes</topic><topic>Photothermal conversion</topic><topic>Photothermal efficiency</topic><topic>Polyvinyl Alcohol</topic><topic>Systems analysis</topic><topic>Toxicity</topic><topic>Viability</topic><toplevel>online_resources</toplevel><creatorcontrib>Almada, M.</creatorcontrib><creatorcontrib>Leal-Martínez, B.H.</creatorcontrib><creatorcontrib>Hassan, N.</creatorcontrib><creatorcontrib>Kogan, M.J.</creatorcontrib><creatorcontrib>Burboa, M.G.</creatorcontrib><creatorcontrib>Topete, A.</creatorcontrib><creatorcontrib>Valdez, M.A.</creatorcontrib><creatorcontrib>Juárez, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almada, M.</au><au>Leal-Martínez, B.H.</au><au>Hassan, N.</au><au>Kogan, M.J.</au><au>Burboa, M.G.</au><au>Topete, A.</au><au>Valdez, M.A.</au><au>Juárez, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol)</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>77</volume><spage>583</spage><epage>593</epage><pages>583-593</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Gold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic GNR system. In this work we replace the CTAB molecules with a thiolated chitosan. Once chitosan coated GNRs (Chi-SH-GNR) were attained, a film of alginate (Alg-Chi-SH-GNR) or polyvinyl alcohol (PVA-Chi-SH-GNR) was deposited onto the surface of Chi-GNR by a layer-by-layer process. The photothermal conversion efficiency for the GNR systems was determined irradiating the GNRs suspended in aqua media with a CW 808nm diode laser (CNI, China). The cytotoxicity effect and the photothermal cellular damage of GNR systems were evaluated on a breast cancer cell line. Results show that polymer coats did not affect the transduction photothermal efficiency. Values around 50% were obtained for the different coated gold nanorods. The cytotoxicity of coated gold nanorods diminished significantly compared with those GNR stabilized with CTAB. The laser irradiation of cells treated with gold nanorods showed a decrease in their viability compared with the cells treated but no irradiated.
•Gold nanorods coated with the biocompatible polymers chitosan, alginate and PVA were synthesized.•The polymer coating does not affect the photothermal efficiency.•Gold nanorods coated with the polymer diminished the cytotoxicity associated with CTAB.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28532069</pmid><doi>10.1016/j.msec.2017.03.218</doi><tpages>11</tpages></addata></record> |
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| subjects | Alcohols Alginate Alginates Alginic acid Breast cancer Cell Line, Tumor Cells China Chitosan Coating Cytotoxicity Damage assessment Efficiency Glucuronic Acid Gold Gold nanorods Hexuronic Acids Humans Irradiation Materials science Molecules Nanorods Nanotubes Photothermal conversion Photothermal efficiency Polyvinyl Alcohol Systems analysis Toxicity Viability |
| title | Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol) |
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