Diagnosis of Zika virus infection on a nanotechnology platform
Antibody-based diagnosis of Zika virus (ZIKV) infection is complicated by cross-reactivity with antibodies against dengue virus. Hongjie Dai and colleagues report their development of a new IgA- and IgG-based diagnostic test that detects ZIKV with high specificity. We developed a multiplexed assay o...
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| Veröffentlicht in: | Nature medicine 2017-05, Vol.23 (5), p.548-550 |
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| container_title | Nature medicine |
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| creator | Zhang, Bo Pinsky, Benjamin A Ananta, Jeyarama S Zhao, Su Arulkumar, Shylaja Wan, Hao Sahoo, Malaya K Abeynayake, Janaki Waggoner, Jesse J Hopes, Clay Tang, Meijie Dai, Hongjie |
| description | Antibody-based diagnosis of Zika virus (ZIKV) infection is complicated by cross-reactivity with antibodies against dengue virus. Hongjie Dai and colleagues report their development of a new IgA- and IgG-based diagnostic test that detects ZIKV with high specificity.
We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections. |
| doi_str_mv | 10.1038/nm.4302 |
| format | Article |
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We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm.4302</identifier><identifier>PMID: 28263312</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>38/77 ; 631/1647/350/59 ; 631/61/32 ; 692/53/2421 ; 692/699/255 ; 9/10 ; 96/34 ; Adult ; Aged ; Antibodies, Viral - immunology ; Antigens, Viral - immunology ; Assay equipment ; Biochemical assays ; Biomedicine ; brief-communication ; Cancer Research ; Cross Reactions ; Dengue - blood ; Dengue - immunology ; Dengue Virus - immunology ; Design and construction ; Diagnosis ; Female ; Flaviviridae ; Gold ; Humans ; Immunoglobulin A - immunology ; Immunoglobulin G - immunology ; Infectious Diseases ; Male ; Medical diagnosis ; Metabolic Diseases ; Methods ; Middle Aged ; Molecular Medicine ; Nanotechnology ; Neurosciences ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Viral - blood ; Vector-borne diseases ; Viral Nonstructural Proteins - immunology ; Young Adult ; Zika virus ; Zika Virus - immunology ; Zika virus infection ; Zika Virus Infection - blood ; Zika Virus Infection - diagnosis ; Zika Virus Infection - immunology</subject><ispartof>Nature medicine, 2017-05, Vol.23 (5), p.548-550</ispartof><rights>Springer Nature America, Inc. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-6320461440dc4d39137117daa89670b0f026bbfeb840ffccf04675ec7fafba783</citedby><cites>FETCH-LOGICAL-c502t-6320461440dc4d39137117daa89670b0f026bbfeb840ffccf04675ec7fafba783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm.4302$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm.4302$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28263312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Pinsky, Benjamin A</creatorcontrib><creatorcontrib>Ananta, Jeyarama S</creatorcontrib><creatorcontrib>Zhao, Su</creatorcontrib><creatorcontrib>Arulkumar, Shylaja</creatorcontrib><creatorcontrib>Wan, Hao</creatorcontrib><creatorcontrib>Sahoo, Malaya K</creatorcontrib><creatorcontrib>Abeynayake, Janaki</creatorcontrib><creatorcontrib>Waggoner, Jesse J</creatorcontrib><creatorcontrib>Hopes, Clay</creatorcontrib><creatorcontrib>Tang, Meijie</creatorcontrib><creatorcontrib>Dai, Hongjie</creatorcontrib><title>Diagnosis of Zika virus infection on a nanotechnology platform</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Antibody-based diagnosis of Zika virus (ZIKV) infection is complicated by cross-reactivity with antibodies against dengue virus. Hongjie Dai and colleagues report their development of a new IgA- and IgG-based diagnostic test that detects ZIKV with high specificity.
We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.</description><subject>38/77</subject><subject>631/1647/350/59</subject><subject>631/61/32</subject><subject>692/53/2421</subject><subject>692/699/255</subject><subject>9/10</subject><subject>96/34</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Viral - immunology</subject><subject>Antigens, Viral - immunology</subject><subject>Assay equipment</subject><subject>Biochemical assays</subject><subject>Biomedicine</subject><subject>brief-communication</subject><subject>Cancer Research</subject><subject>Cross Reactions</subject><subject>Dengue - blood</subject><subject>Dengue - immunology</subject><subject>Dengue Virus - immunology</subject><subject>Design and construction</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Flaviviridae</subject><subject>Gold</subject><subject>Humans</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin G - 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Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Bo</au><au>Pinsky, Benjamin A</au><au>Ananta, Jeyarama S</au><au>Zhao, Su</au><au>Arulkumar, Shylaja</au><au>Wan, Hao</au><au>Sahoo, Malaya K</au><au>Abeynayake, Janaki</au><au>Waggoner, Jesse J</au><au>Hopes, Clay</au><au>Tang, Meijie</au><au>Dai, Hongjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of Zika virus infection on a nanotechnology platform</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>23</volume><issue>5</issue><spage>548</spage><epage>550</epage><pages>548-550</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Antibody-based diagnosis of Zika virus (ZIKV) infection is complicated by cross-reactivity with antibodies against dengue virus. Hongjie Dai and colleagues report their development of a new IgA- and IgG-based diagnostic test that detects ZIKV with high specificity.
We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28263312</pmid><doi>10.1038/nm.4302</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | 38/77 631/1647/350/59 631/61/32 692/53/2421 692/699/255 9/10 96/34 Adult Aged Antibodies, Viral - immunology Antigens, Viral - immunology Assay equipment Biochemical assays Biomedicine brief-communication Cancer Research Cross Reactions Dengue - blood Dengue - immunology Dengue Virus - immunology Design and construction Diagnosis Female Flaviviridae Gold Humans Immunoglobulin A - immunology Immunoglobulin G - immunology Infectious Diseases Male Medical diagnosis Metabolic Diseases Methods Middle Aged Molecular Medicine Nanotechnology Neurosciences Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - blood Vector-borne diseases Viral Nonstructural Proteins - immunology Young Adult Zika virus Zika Virus - immunology Zika virus infection Zika Virus Infection - blood Zika Virus Infection - diagnosis Zika Virus Infection - immunology |
| title | Diagnosis of Zika virus infection on a nanotechnology platform |
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