Computed tomographic findings in subjects who died from respiratory disease in the National Lung Screening Trial
We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respirato...
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| Veröffentlicht in: | The European respiratory journal 2017-04, Vol.49 (4), p.1601814-1601814 |
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| container_title | The European respiratory journal |
| container_volume | 49 |
| creator | Pompe, Esther de Jong, Pim A Lynch, David A Lessmann, Nikolas Išgum, Ivana van Ginneken, Bram Lammers, Jan-Willem J Mohamed Hoesein, Firdaus A A |
| description | We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respiratory illness other than lung cancer were matched for age, sex, pack-years and smoking status to a surviving control. A chest radiologist and a radiology resident blinded to the outcome independently scored baseline CT scans visually and qualitatively for the presence of emphysema, airway wall thickening and fibrotic lung disease. The prevalence of CT abnormalities was compared between cases and controls by using chi-squared tests.In total, 167 participants died from a respiratory cause other than lung cancer. The prevalence of severe emphysema, airway wall thickening and fibrotic lung disease were 28.7%
4.8%, 26.9%
13.2% and 18.6%
0.5% in cases and controls, respectively. Radiological findings were significantly more prevalent in deaths compared with controls (all p |
| doi_str_mv | 10.1183/13993003.01814-2016 |
| format | Article |
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4.8%, 26.9%
13.2% and 18.6%
0.5% in cases and controls, respectively. Radiological findings were significantly more prevalent in deaths compared with controls (all p<0.001).CT-diagnosed severe emphysema, airway wall thickening and fibrosis were much more common in NLST participants who died from respiratory disease, and CT may provide an additional means of identifying these diseases.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/13993003.01814-2016</identifier><identifier>PMID: 28424361</identifier><language>eng</language><publisher>England: European Respiratory Society Journals Ltd</publisher><subject>Aged ; Case-Control Studies ; Cause of Death ; Computed tomography ; Death Certificates ; Emphysema ; Female ; Fibrosis ; Humans ; Lung - diagnostic imaging ; Lung - pathology ; Lung cancer ; Lung diseases ; Male ; Mass Screening - methods ; Middle Aged ; Netherlands ; Prevalence ; Radiology ; Respiratory diseases ; Respiratory tract ; Respiratory Tract Diseases - classification ; Respiratory Tract Diseases - diagnostic imaging ; Retrospective Studies ; Smoking ; Tomography, X-Ray Computed</subject><ispartof>The European respiratory journal, 2017-04, Vol.49 (4), p.1601814-1601814</ispartof><rights>Copyright ©ERS 2017.</rights><rights>Copyright European Respiratory Society Journals Ltd. Apr 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-4e74af223dffa40d4279dcbeb6655f53ff2d6182c7406bbd4432d0c048246a133</citedby><cites>FETCH-LOGICAL-c411t-4e74af223dffa40d4279dcbeb6655f53ff2d6182c7406bbd4432d0c048246a133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28424361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pompe, Esther</creatorcontrib><creatorcontrib>de Jong, Pim A</creatorcontrib><creatorcontrib>Lynch, David A</creatorcontrib><creatorcontrib>Lessmann, Nikolas</creatorcontrib><creatorcontrib>Išgum, Ivana</creatorcontrib><creatorcontrib>van Ginneken, Bram</creatorcontrib><creatorcontrib>Lammers, Jan-Willem J</creatorcontrib><creatorcontrib>Mohamed Hoesein, Firdaus A A</creatorcontrib><title>Computed tomographic findings in subjects who died from respiratory disease in the National Lung Screening Trial</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respiratory illness other than lung cancer were matched for age, sex, pack-years and smoking status to a surviving control. A chest radiologist and a radiology resident blinded to the outcome independently scored baseline CT scans visually and qualitatively for the presence of emphysema, airway wall thickening and fibrotic lung disease. The prevalence of CT abnormalities was compared between cases and controls by using chi-squared tests.In total, 167 participants died from a respiratory cause other than lung cancer. The prevalence of severe emphysema, airway wall thickening and fibrotic lung disease were 28.7%
4.8%, 26.9%
13.2% and 18.6%
0.5% in cases and controls, respectively. Radiological findings were significantly more prevalent in deaths compared with controls (all p<0.001).CT-diagnosed severe emphysema, airway wall thickening and fibrosis were much more common in NLST participants who died from respiratory disease, and CT may provide an additional means of identifying these diseases.</description><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Cause of Death</subject><subject>Computed tomography</subject><subject>Death Certificates</subject><subject>Emphysema</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - pathology</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Middle Aged</subject><subject>Netherlands</subject><subject>Prevalence</subject><subject>Radiology</subject><subject>Respiratory diseases</subject><subject>Respiratory tract</subject><subject>Respiratory Tract Diseases - classification</subject><subject>Respiratory Tract Diseases - diagnostic imaging</subject><subject>Retrospective Studies</subject><subject>Smoking</subject><subject>Tomography, X-Ray Computed</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAUhYMoOj5-gSABN26quUkm0yxl8AWDLhzXJc1jJkPb1KRF_Pe2OuPCjasLh-8cuHwInQO5BsjZDTApGSHsmkAOPKMExB6ajGk2xvtoQiRhGUgmjtBxShsyEJzBITqiOaecCZigdh7qtu-swV2owyqqdu01dr4xvlkl7Buc-nJjdZfwxzpg4wfSxVDjaFPro-pC_BzSZFWyI92tLX5WnQ-NqvCib1b4VUdrm2ENL6NX1Sk6cKpK9mx7T9Db_d1y_pgtXh6e5reLTHOALuN2xpWjlBnnFCeG05k0urSlENOpmzLnqBGQUz3jRJSl4ZxRQzThOeVCAWMn6Opnt43hvbepK2qftK0q1djQpwIkgRmnksv_0VwCkQASBvTyD7oJfRx-HQdzJqkEMVLsh9IxpBStK9roaxU_CyDF6K7YuSu-3RWju6F1sd3uy9qa385OFvsCWMqT1Q</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Pompe, Esther</creator><creator>de Jong, Pim A</creator><creator>Lynch, David A</creator><creator>Lessmann, Nikolas</creator><creator>Išgum, Ivana</creator><creator>van Ginneken, Bram</creator><creator>Lammers, Jan-Willem J</creator><creator>Mohamed Hoesein, Firdaus A A</creator><general>European Respiratory Society Journals Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Computed tomographic findings in subjects who died from respiratory disease in the National Lung Screening Trial</title><author>Pompe, Esther ; de Jong, Pim A ; Lynch, David A ; Lessmann, Nikolas ; Išgum, Ivana ; van Ginneken, Bram ; Lammers, Jan-Willem J ; Mohamed Hoesein, Firdaus A A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-4e74af223dffa40d4279dcbeb6655f53ff2d6182c7406bbd4432d0c048246a133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Cause of Death</topic><topic>Computed tomography</topic><topic>Death Certificates</topic><topic>Emphysema</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - pathology</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Middle Aged</topic><topic>Netherlands</topic><topic>Prevalence</topic><topic>Radiology</topic><topic>Respiratory diseases</topic><topic>Respiratory tract</topic><topic>Respiratory Tract Diseases - classification</topic><topic>Respiratory Tract Diseases - diagnostic imaging</topic><topic>Retrospective Studies</topic><topic>Smoking</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pompe, Esther</creatorcontrib><creatorcontrib>de Jong, Pim A</creatorcontrib><creatorcontrib>Lynch, David A</creatorcontrib><creatorcontrib>Lessmann, Nikolas</creatorcontrib><creatorcontrib>Išgum, Ivana</creatorcontrib><creatorcontrib>van Ginneken, Bram</creatorcontrib><creatorcontrib>Lammers, Jan-Willem J</creatorcontrib><creatorcontrib>Mohamed Hoesein, Firdaus A A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pompe, Esther</au><au>de Jong, Pim A</au><au>Lynch, David A</au><au>Lessmann, Nikolas</au><au>Išgum, Ivana</au><au>van Ginneken, Bram</au><au>Lammers, Jan-Willem J</au><au>Mohamed Hoesein, Firdaus A A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computed tomographic findings in subjects who died from respiratory disease in the National Lung Screening Trial</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>49</volume><issue>4</issue><spage>1601814</spage><epage>1601814</epage><pages>1601814-1601814</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respiratory illness other than lung cancer were matched for age, sex, pack-years and smoking status to a surviving control. A chest radiologist and a radiology resident blinded to the outcome independently scored baseline CT scans visually and qualitatively for the presence of emphysema, airway wall thickening and fibrotic lung disease. The prevalence of CT abnormalities was compared between cases and controls by using chi-squared tests.In total, 167 participants died from a respiratory cause other than lung cancer. The prevalence of severe emphysema, airway wall thickening and fibrotic lung disease were 28.7%
4.8%, 26.9%
13.2% and 18.6%
0.5% in cases and controls, respectively. Radiological findings were significantly more prevalent in deaths compared with controls (all p<0.001).CT-diagnosed severe emphysema, airway wall thickening and fibrosis were much more common in NLST participants who died from respiratory disease, and CT may provide an additional means of identifying these diseases.</abstract><cop>England</cop><pub>European Respiratory Society Journals Ltd</pub><pmid>28424361</pmid><doi>10.1183/13993003.01814-2016</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Case-Control Studies Cause of Death Computed tomography Death Certificates Emphysema Female Fibrosis Humans Lung - diagnostic imaging Lung - pathology Lung cancer Lung diseases Male Mass Screening - methods Middle Aged Netherlands Prevalence Radiology Respiratory diseases Respiratory tract Respiratory Tract Diseases - classification Respiratory Tract Diseases - diagnostic imaging Retrospective Studies Smoking Tomography, X-Ray Computed |
| title | Computed tomographic findings in subjects who died from respiratory disease in the National Lung Screening Trial |
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