The effect of heritability and host genetics on the gut microbiota and metabolic syndrome
ObjectiveMetabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to...
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| Veröffentlicht in: | Gut 2017-06, Vol.66 (6), p.1031-1038 |
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| creator | Lim, Mi Young You, Hyun Ju Yoon, Hyo Shin Kwon, Bomi Lee, Jae Yoon Lee, Sunghee Song, Yun-Mi Lee, Kayoung Sung, Joohon Ko, GwangPyo |
| description | ObjectiveMetabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remains limited. Here, we investigated the links among host genetic factors, gut microbiota and MetS in humans.DesignWe characterised the gut microbial community composition of 655 monozygotic (n=306) and dizygotic (n=74) twins and their families (n=275), of which approximately 18% (121 individuals) had MetS. We evaluated the association of MetS status with the gut microbiota and estimated the heritability of each taxon. For the MetS-related and heritable taxa, we further investigated their associations with the apolipoprotein A-V gene (APOA5) single nucleotide polymorphism (SNP) rs651821, which is known to be associated with triglyceride levels and MetS.ResultsIndividuals with MetS had a lower gut microbiota diversity than healthy individuals. The abundances of several taxa were associated with MetS status; Sutterella, Methanobrevibacter and Lactobacillus were enriched in the MetS group, whereas Akkermansia, Odoribacter and Bifidobacterium were enriched in the healthy group. Among the taxa associated with MetS status, the phylum Actinobacteria, to which Bifidobacterium belongs, had the highest heritability (45.7%). Even after adjustment for MetS status, reduced abundances of Actinobacteria and Bifidobacterium were significantly linked to the minor allele at the APOA5 SNP rs651821.ConclusionsOur results suggest that an altered microbiota composition mediated by a specific host genotype can contribute to the development of MetS. |
| doi_str_mv | 10.1136/gutjnl-2015-311326 |
| format | Article |
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Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remains limited. Here, we investigated the links among host genetic factors, gut microbiota and MetS in humans.DesignWe characterised the gut microbial community composition of 655 monozygotic (n=306) and dizygotic (n=74) twins and their families (n=275), of which approximately 18% (121 individuals) had MetS. We evaluated the association of MetS status with the gut microbiota and estimated the heritability of each taxon. For the MetS-related and heritable taxa, we further investigated their associations with the apolipoprotein A-V gene (APOA5) single nucleotide polymorphism (SNP) rs651821, which is known to be associated with triglyceride levels and MetS.ResultsIndividuals with MetS had a lower gut microbiota diversity than healthy individuals. The abundances of several taxa were associated with MetS status; Sutterella, Methanobrevibacter and Lactobacillus were enriched in the MetS group, whereas Akkermansia, Odoribacter and Bifidobacterium were enriched in the healthy group. Among the taxa associated with MetS status, the phylum Actinobacteria, to which Bifidobacterium belongs, had the highest heritability (45.7%). Even after adjustment for MetS status, reduced abundances of Actinobacteria and Bifidobacterium were significantly linked to the minor allele at the APOA5 SNP rs651821.ConclusionsOur results suggest that an altered microbiota composition mediated by a specific host genotype can contribute to the development of MetS.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2015-311326</identifier><identifier>PMID: 27053630</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject><![CDATA[Actinobacteria ; Adult ; Age ; Aged ; Aged, 80 and over ; Alleles ; Apolipoprotein A ; Apolipoprotein A-V - genetics ; Apolipoproteins ; Bacteroidetes - isolation & purification ; Betaproteobacteria - isolation & purification ; Bifidobacterium ; Bifidobacterium - isolation & purification ; Cardiovascular disease ; Community composition ; Diabetes ; Diet ; Dysbiosis - microbiology ; Environmental factors ; Feces - microbiology ; Female ; Gastrointestinal Microbiome ; Gene polymorphism ; Gene-Environment Interaction ; Genes ; Genetic factors ; Genetics ; Genotype ; Heritability ; Humans ; Intestinal microflora ; Lactobacillus ; Lactobacillus - isolation & purification ; Low density lipoprotein ; Male ; Metabolic syndrome ; Metabolic Syndrome - genetics ; Metabolic Syndrome - microbiology ; Methanobrevibacter ; Methanobrevibacter - isolation & purification ; Microbiota ; Middle Aged ; Obesity ; Polymorphism, Single Nucleotide ; Probiotics ; RNA, Ribosomal, 16S - analysis ; Single-nucleotide polymorphism ; Studies ; Sutterella ; Twins ; Verrucomicrobia - isolation & purification ; Womens health ; Young Adult]]></subject><ispartof>Gut, 2017-06, Vol.66 (6), p.1031-1038</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</rights><rights>Copyright: 2016 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b468t-264f8c2401caf57b688154cc067bf030c50a5468ae25a7a221e0a34a82b3f5813</citedby><cites>FETCH-LOGICAL-b468t-264f8c2401caf57b688154cc067bf030c50a5468ae25a7a221e0a34a82b3f5813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27053630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Mi Young</creatorcontrib><creatorcontrib>You, Hyun Ju</creatorcontrib><creatorcontrib>Yoon, Hyo Shin</creatorcontrib><creatorcontrib>Kwon, Bomi</creatorcontrib><creatorcontrib>Lee, Jae Yoon</creatorcontrib><creatorcontrib>Lee, Sunghee</creatorcontrib><creatorcontrib>Song, Yun-Mi</creatorcontrib><creatorcontrib>Lee, Kayoung</creatorcontrib><creatorcontrib>Sung, Joohon</creatorcontrib><creatorcontrib>Ko, GwangPyo</creatorcontrib><title>The effect of heritability and host genetics on the gut microbiota and metabolic syndrome</title><title>Gut</title><addtitle>Gut</addtitle><description>ObjectiveMetabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remains limited. Here, we investigated the links among host genetic factors, gut microbiota and MetS in humans.DesignWe characterised the gut microbial community composition of 655 monozygotic (n=306) and dizygotic (n=74) twins and their families (n=275), of which approximately 18% (121 individuals) had MetS. We evaluated the association of MetS status with the gut microbiota and estimated the heritability of each taxon. For the MetS-related and heritable taxa, we further investigated their associations with the apolipoprotein A-V gene (APOA5) single nucleotide polymorphism (SNP) rs651821, which is known to be associated with triglyceride levels and MetS.ResultsIndividuals with MetS had a lower gut microbiota diversity than healthy individuals. The abundances of several taxa were associated with MetS status; Sutterella, Methanobrevibacter and Lactobacillus were enriched in the MetS group, whereas Akkermansia, Odoribacter and Bifidobacterium were enriched in the healthy group. Among the taxa associated with MetS status, the phylum Actinobacteria, to which Bifidobacterium belongs, had the highest heritability (45.7%). Even after adjustment for MetS status, reduced abundances of Actinobacteria and Bifidobacterium were significantly linked to the minor allele at the APOA5 SNP rs651821.ConclusionsOur results suggest that an altered microbiota composition mediated by a specific host genotype can contribute to the development of MetS.</description><subject>Actinobacteria</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Apolipoprotein A</subject><subject>Apolipoprotein A-V - genetics</subject><subject>Apolipoproteins</subject><subject>Bacteroidetes - isolation & purification</subject><subject>Betaproteobacteria - isolation & purification</subject><subject>Bifidobacterium</subject><subject>Bifidobacterium - isolation & purification</subject><subject>Cardiovascular disease</subject><subject>Community composition</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Dysbiosis - microbiology</subject><subject>Environmental factors</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome</subject><subject>Gene polymorphism</subject><subject>Gene-Environment Interaction</subject><subject>Genes</subject><subject>Genetic factors</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Heritability</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Lactobacillus</subject><subject>Lactobacillus - isolation & purification</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - genetics</subject><subject>Metabolic Syndrome - microbiology</subject><subject>Methanobrevibacter</subject><subject>Methanobrevibacter - isolation & purification</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Probiotics</subject><subject>RNA, Ribosomal, 16S - analysis</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Sutterella</subject><subject>Twins</subject><subject>Verrucomicrobia - isolation & purification</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0017-5749</issn><issn>1468-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU9PwyAYh4nRuDn9Ah4MiRcv1RcoLT2axX_JEi_z4KmhDDaatsxCD_v2Mjs9eFEuJOT5_YD3QeiSwC0hLLtbD6HumoQC4QmLJzQ7QlOSZiJhVIhjNAUgecLztJigM-9rABCiIKdoQnPgLGMwRe_LjcbaGK0CdgZvdG-DrGxjww7LboU3zge81p0OVnnsOhwiHy_GrVW9q6wL8otrdYy5xirsd92qd60-RydGNl5fHPYZent8WM6fk8Xr08v8fpFU8aUhoVlqhKIpECUNz6tMCMJTpSDLKwMMFAfJIyk15TKXlBINkqVS0IoZLgiboZuxd9u7j0H7ULbWK900stNu8CUp4hRSCkXxNypoFhcTENHrX2jthr6LH4lUITgtCrKn6EjFWXjfa1Nue9vKflcSKPeOytFRuXdUjo5i6OpQPVStXv1EvqVEIBmBqq3_U_gJpPaa9Q</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Lim, Mi Young</creator><creator>You, Hyun Ju</creator><creator>Yoon, Hyo Shin</creator><creator>Kwon, Bomi</creator><creator>Lee, Jae Yoon</creator><creator>Lee, Sunghee</creator><creator>Song, Yun-Mi</creator><creator>Lee, Kayoung</creator><creator>Sung, Joohon</creator><creator>Ko, GwangPyo</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20170601</creationdate><title>The effect of heritability and host genetics on the gut microbiota and metabolic syndrome</title><author>Lim, Mi Young ; You, Hyun Ju ; Yoon, Hyo Shin ; Kwon, Bomi ; Lee, Jae Yoon ; Lee, Sunghee ; Song, Yun-Mi ; Lee, Kayoung ; Sung, Joohon ; Ko, GwangPyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b468t-264f8c2401caf57b688154cc067bf030c50a5468ae25a7a221e0a34a82b3f5813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Actinobacteria</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Apolipoprotein A</topic><topic>Apolipoprotein A-V - genetics</topic><topic>Apolipoproteins</topic><topic>Bacteroidetes - isolation & purification</topic><topic>Betaproteobacteria - isolation & purification</topic><topic>Bifidobacterium</topic><topic>Bifidobacterium - isolation & purification</topic><topic>Cardiovascular disease</topic><topic>Community composition</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Dysbiosis - microbiology</topic><topic>Environmental factors</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastrointestinal Microbiome</topic><topic>Gene polymorphism</topic><topic>Gene-Environment Interaction</topic><topic>Genes</topic><topic>Genetic factors</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Heritability</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Lactobacillus</topic><topic>Lactobacillus - isolation & purification</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - genetics</topic><topic>Metabolic Syndrome - microbiology</topic><topic>Methanobrevibacter</topic><topic>Methanobrevibacter - isolation & purification</topic><topic>Microbiota</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Probiotics</topic><topic>RNA, Ribosomal, 16S - analysis</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>Sutterella</topic><topic>Twins</topic><topic>Verrucomicrobia - isolation & purification</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Mi Young</creatorcontrib><creatorcontrib>You, Hyun Ju</creatorcontrib><creatorcontrib>Yoon, Hyo Shin</creatorcontrib><creatorcontrib>Kwon, Bomi</creatorcontrib><creatorcontrib>Lee, Jae Yoon</creatorcontrib><creatorcontrib>Lee, Sunghee</creatorcontrib><creatorcontrib>Song, Yun-Mi</creatorcontrib><creatorcontrib>Lee, Kayoung</creatorcontrib><creatorcontrib>Sung, Joohon</creatorcontrib><creatorcontrib>Ko, GwangPyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Mi Young</au><au>You, Hyun Ju</au><au>Yoon, Hyo Shin</au><au>Kwon, Bomi</au><au>Lee, Jae Yoon</au><au>Lee, Sunghee</au><au>Song, Yun-Mi</au><au>Lee, Kayoung</au><au>Sung, Joohon</au><au>Ko, GwangPyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of heritability and host genetics on the gut microbiota and metabolic syndrome</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>66</volume><issue>6</issue><spage>1031</spage><epage>1038</epage><pages>1031-1038</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><abstract>ObjectiveMetabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remains limited. Here, we investigated the links among host genetic factors, gut microbiota and MetS in humans.DesignWe characterised the gut microbial community composition of 655 monozygotic (n=306) and dizygotic (n=74) twins and their families (n=275), of which approximately 18% (121 individuals) had MetS. We evaluated the association of MetS status with the gut microbiota and estimated the heritability of each taxon. For the MetS-related and heritable taxa, we further investigated their associations with the apolipoprotein A-V gene (APOA5) single nucleotide polymorphism (SNP) rs651821, which is known to be associated with triglyceride levels and MetS.ResultsIndividuals with MetS had a lower gut microbiota diversity than healthy individuals. The abundances of several taxa were associated with MetS status; Sutterella, Methanobrevibacter and Lactobacillus were enriched in the MetS group, whereas Akkermansia, Odoribacter and Bifidobacterium were enriched in the healthy group. Among the taxa associated with MetS status, the phylum Actinobacteria, to which Bifidobacterium belongs, had the highest heritability (45.7%). Even after adjustment for MetS status, reduced abundances of Actinobacteria and Bifidobacterium were significantly linked to the minor allele at the APOA5 SNP rs651821.ConclusionsOur results suggest that an altered microbiota composition mediated by a specific host genotype can contribute to the development of MetS.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>27053630</pmid><doi>10.1136/gutjnl-2015-311326</doi><tpages>8</tpages></addata></record> |
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| subjects | Actinobacteria Adult Age Aged Aged, 80 and over Alleles Apolipoprotein A Apolipoprotein A-V - genetics Apolipoproteins Bacteroidetes - isolation & purification Betaproteobacteria - isolation & purification Bifidobacterium Bifidobacterium - isolation & purification Cardiovascular disease Community composition Diabetes Diet Dysbiosis - microbiology Environmental factors Feces - microbiology Female Gastrointestinal Microbiome Gene polymorphism Gene-Environment Interaction Genes Genetic factors Genetics Genotype Heritability Humans Intestinal microflora Lactobacillus Lactobacillus - isolation & purification Low density lipoprotein Male Metabolic syndrome Metabolic Syndrome - genetics Metabolic Syndrome - microbiology Methanobrevibacter Methanobrevibacter - isolation & purification Microbiota Middle Aged Obesity Polymorphism, Single Nucleotide Probiotics RNA, Ribosomal, 16S - analysis Single-nucleotide polymorphism Studies Sutterella Twins Verrucomicrobia - isolation & purification Womens health Young Adult |
| title | The effect of heritability and host genetics on the gut microbiota and metabolic syndrome |
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