Effect of Combined Action of Extracellular ATP and Elevated Calcium on Osteogenic Differentiation of Primary Cultures From Rat Calvaria

ABSTRACT The in vitro osteogenic differentiation has been intensively studied. However, it is not yet clear precisely how osteogenesis can be optimized. Changes in extracellular Ca2+ concentration ([Ca2+]e), as well as modulation of purinergic receptors play an important role in the regulation of os...

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Veröffentlicht in:	Journal of cellular biochemistry 2016-11, Vol.117 (11), p.2658-2668
Hauptverfasser:	Laiuppa, Juan A., Santillán, Graciela E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Animals, Newborn Blotting, Western Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Bone Morphogenetic Protein 5 - genetics Bone Morphogenetic Protein 5 - metabolism CALCIUM Calcium - pharmacology Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Drug Combinations EXTRACELLULAR ATP GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism OSTEOGENESIS Osteogenesis - drug effects Osteogenesis - physiology PURINERGIC RECEPTORS Rats Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Skull - cytology Skull - drug effects Skull - metabolism
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