Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs

Colchicine (COL) is a well-known and potent microtubule targeting anticancer agent. The purpose of our study was to identify conditions that increase sensitization of COL-resistant cancer cells that overexpress P-glycoprotein (P-gp). The anti-malarial drugs chloroquine (CHL), mefloquine (MEF) and pr...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Anticancer research 2016-11, Vol.36 (11), p.5859-5866
Hauptverfasser:	Choi, Ae-Ran, Kim, Ju-Hwa, Cheon, Ji Hyun, Kim, Hyung Sik, Yoon, Sungpil
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Cell Line, Tumor Colchicine - toxicity Drug Resistance, Neoplasm Histones - metabolism Humans
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!