Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot
Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biote...
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| Veröffentlicht in: | Advances in colloid and interface science 2017-11, Vol.249, p.163-180 |
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| creator | Milcovich, Gesmi Lettieri, Stefania Antunes, Filipe E. Medronho, Bruno Fonseca, Ana C. Coelho, Jorge F.J. Marizza, Paolo Perrone, Francesca Farra, Rossella Dapas, Barbara Grassi, Gabriele Grassi, Mario Giordani, Silvia |
| description | Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications.
In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
[Display omitted]
Tailored bioactive molecule delivery can be targeted towards several colloidal structures, such as:•Hydrogels•Surfactant self-assembly•Covalently functionalized colloidal structures•Polymers assembly features•Carbon nano materials |
| doi_str_mv | 10.1016/j.cis.2017.05.009 |
| format | Article |
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In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
[Display omitted]
Tailored bioactive molecule delivery can be targeted towards several colloidal structures, such as:•Hydrogels•Surfactant self-assembly•Covalently functionalized colloidal structures•Polymers assembly features•Carbon nano materials</description><identifier>ISSN: 0001-8686</identifier><identifier>EISSN: 1873-3727</identifier><identifier>DOI: 10.1016/j.cis.2017.05.009</identifier><identifier>PMID: 28527520</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antibodies - pharmacology ; Bioactive molecule delivery ; Carbon nano materials ; Diagnostic Imaging - methods ; Drug Delivery Systems - methods ; Humans ; Hydrogels ; Hydrogels - chemistry ; Intercellular Signaling Peptides and Proteins - genetics ; Intercellular Signaling Peptides and Proteins - metabolism ; Liposomes ; Liposomes - chemistry ; Liposomes - metabolism ; Mice ; Micro/nanocarriers ; Molecular Probes - chemical synthesis ; Molecular Targeted Therapy ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Nanotechnology - methods ; Plasmids - chemistry ; Plasmids - metabolism ; RNA, Small Interfering - genetics ; RNA, Small Interfering - metabolism ; Small Molecule Libraries - chemical synthesis ; Small Molecule Libraries - pharmacology ; Transgenes</subject><ispartof>Advances in colloid and interface science, 2017-11, Vol.249, p.163-180</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-f81296a5f17acc6d817710ed9663f74c31f8fee0225414a907b29399377b070a3</citedby><cites>FETCH-LOGICAL-c461t-f81296a5f17acc6d817710ed9663f74c31f8fee0225414a907b29399377b070a3</cites><orcidid>0000-0003-0972-1739 ; 0000-0002-9212-5067</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0001868617301215$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28527520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Milcovich, Gesmi</creatorcontrib><creatorcontrib>Lettieri, Stefania</creatorcontrib><creatorcontrib>Antunes, Filipe E.</creatorcontrib><creatorcontrib>Medronho, Bruno</creatorcontrib><creatorcontrib>Fonseca, Ana C.</creatorcontrib><creatorcontrib>Coelho, Jorge F.J.</creatorcontrib><creatorcontrib>Marizza, Paolo</creatorcontrib><creatorcontrib>Perrone, Francesca</creatorcontrib><creatorcontrib>Farra, Rossella</creatorcontrib><creatorcontrib>Dapas, Barbara</creatorcontrib><creatorcontrib>Grassi, Gabriele</creatorcontrib><creatorcontrib>Grassi, Mario</creatorcontrib><creatorcontrib>Giordani, Silvia</creatorcontrib><title>Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot</title><title>Advances in colloid and interface science</title><addtitle>Adv Colloid Interface Sci</addtitle><description>Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications.
In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
[Display omitted]
Tailored bioactive molecule delivery can be targeted towards several colloidal structures, such as:•Hydrogels•Surfactant self-assembly•Covalently functionalized colloidal structures•Polymers assembly features•Carbon nano materials</description><subject>Animals</subject><subject>Antibodies - pharmacology</subject><subject>Bioactive molecule delivery</subject><subject>Carbon nano materials</subject><subject>Diagnostic Imaging - methods</subject><subject>Drug Delivery Systems - methods</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Liposomes</subject><subject>Liposomes - chemistry</subject><subject>Liposomes - metabolism</subject><subject>Mice</subject><subject>Micro/nanocarriers</subject><subject>Molecular Probes - chemical synthesis</subject><subject>Molecular Targeted Therapy</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - metabolism</subject><subject>Nanotechnology - methods</subject><subject>Plasmids - chemistry</subject><subject>Plasmids - metabolism</subject><subject>RNA, Small Interfering - genetics</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Small Molecule Libraries - chemical synthesis</subject><subject>Small Molecule Libraries - pharmacology</subject><subject>Transgenes</subject><issn>0001-8686</issn><issn>1873-3727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrGzEQRkVpaZy0P6CXomMvu5mRvNJuewqmTQKBQGnPQpZmU5n1ypVkg_99ZZzmmJMYeN8DPcY-IbQIqK43rQu5FYC6ha4FGN6wBfZaNlIL_ZYtAACbXvXqgl3mvKmn6HT3nl2IvhO6E7Bg4Sc5mgu3_mBnR5mHmeetTYWvQyzk_sxxik_Hr_zu6FN8oilzO3s-2zk6m1KglPkYEy82TDGRP82sK-FAfBsncvupOj3tYvnA3o12yvTx-b1iv398_7W6ax4eb-9XNw-NWyoszdijGJTtRtTWOeV71BqB_KCUHPXSSRz7kQiE6Ja4tAPotRjkMEit16DByiv25ezdpfh3T7mYbciOpsnOFPfZ4AAoEUDJiuIZdSnmnGg0uxTq548GwZwKm42phc2psIHO1MJ18_lZv19vyb8s_ietwLczUFvRoQYy2QWqbX1I5IrxMbyi_wd0fYyV</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Milcovich, Gesmi</creator><creator>Lettieri, Stefania</creator><creator>Antunes, Filipe E.</creator><creator>Medronho, Bruno</creator><creator>Fonseca, Ana C.</creator><creator>Coelho, Jorge F.J.</creator><creator>Marizza, Paolo</creator><creator>Perrone, Francesca</creator><creator>Farra, Rossella</creator><creator>Dapas, Barbara</creator><creator>Grassi, Gabriele</creator><creator>Grassi, Mario</creator><creator>Giordani, Silvia</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0972-1739</orcidid><orcidid>https://orcid.org/0000-0002-9212-5067</orcidid></search><sort><creationdate>20171101</creationdate><title>Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot</title><author>Milcovich, Gesmi ; 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In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
[Display omitted]
Tailored bioactive molecule delivery can be targeted towards several colloidal structures, such as:•Hydrogels•Surfactant self-assembly•Covalently functionalized colloidal structures•Polymers assembly features•Carbon nano materials</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28527520</pmid><doi>10.1016/j.cis.2017.05.009</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0003-0972-1739</orcidid><orcidid>https://orcid.org/0000-0002-9212-5067</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies - pharmacology Bioactive molecule delivery Carbon nano materials Diagnostic Imaging - methods Drug Delivery Systems - methods Humans Hydrogels Hydrogels - chemistry Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Liposomes Liposomes - chemistry Liposomes - metabolism Mice Micro/nanocarriers Molecular Probes - chemical synthesis Molecular Targeted Therapy Nanoparticles - chemistry Nanoparticles - metabolism Nanotechnology - methods Plasmids - chemistry Plasmids - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Small Molecule Libraries - chemical synthesis Small Molecule Libraries - pharmacology Transgenes |
| title | Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot |
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