X-linked Carriers of Chronic Granulomatous Disease: Illness, Lyonization and Stability

Abstract Background Chronic granulomatous disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infections and aberrant inflammation. Mutations in CYBB cause X-linked CGD and account for 65%-70% of cases in western countries. Objective To understand the clinical manifesta...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2018-01, Vol.141 (1), p.365-371
Hauptverfasser:	Marciano, Beatriz E., MD, Zerbe, Christa S., MD, Falcone, E. Liana, MD PhD, Ding, Li, MD, DeRavin, Suk See, MD PhD, Daub, Janine, CRNP, Kreuzburg, Samantha, CRNP, Yockey, Lynne, CRNP, Hunsberger, Sally, PHD, Foruraghi, Ladan, CRNP, Barnhart, Lisa A., CRNP, Matharu, Kabir, MD, Anderson, Victoria, CRNP, Darnell, Dirk N., CRNP, Frein, Cathleen, CRNP, Fink, Danielle L., MS, Lau, Karen P., MS, Long Priel, Debra A., MS, Gallin, John I., MD, Malech, Harry L., MD, Uzel, Gulbu, MD, Freeman, Alexandra F., MD, Kuhns, Douglas B., PhD, Rosenzweig, Sergio D., MD PhD, Holland, Steven M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Allergy and Immunology Arthritis Autoimmunity Bacteria Biomarkers Child Child, Preschool Chromosomes Chronic granulomatous disease dihydrorhodamine flow cytometry test Disease Female Genes, X-Linked Genetic Association Studies Granulomatous Disease, Chronic - complications Granulomatous Disease, Chronic - diagnosis Granulomatous Disease, Chronic - genetics Granulomatous Disease, Chronic - immunology Health risks Heterozygote Humans Immunoglobulin G - immunology Immunoglobulin M - immunology Inactivation Infant Infection - etiology Infections Inflammation Lupus lyonization Middle Aged Mutation Neutrophils Odds Ratio Oxidation Patients Phenotype Software Superoxide Symptom Assessment X Chromosome Inactivation X chromosomes X inactivation Young Adult
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