Human papillomavirus molecular biology

Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologi...

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Veröffentlicht in:	Mutation research 2017-04, Vol.772, p.3-12
Hauptverfasser:	Harden, Mallory E., Munger, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Squamous Cell - prevention & control Carcinoma, Squamous Cell - virology Cervical cancer Epithelial differentiation Epithelium - pathology Epithelium - virology Genome, Viral Human papillomavirus Humans Molecular Biology Mouth Neoplasms - pathology Mouth Neoplasms - virology Neoplasms, Squamous Cell - prevention & control Neoplasms, Squamous Cell - virology Oncogene Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - physiology Papillomavirus Vaccines - therapeutic use Tumor suppressor Vaccine Viral Proteins - genetics
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Beschreibung
Zusammenfassung:	Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses.
ISSN:	1383-5742 0027-5107 1388-2139 1873-135X
DOI:	10.1016/j.mrrev.2016.07.002