Metformin attenuates renal fibrosis in both AMPKα2‐dependent and independent manners

Summary Metformin is a well‐known AMP‐activated protein kinase (AMPK) activator, and it has been shown to inhibit organ fibrosis. Whether AMPKα2 mediates metformin protection against renal fibrosis remains unknown. Here, we aimed to investigate the role of the AMPKα2 isoform in mediating the inhibit...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2017-06, Vol.44 (6), p.648-655
Hauptverfasser:	Feng, Yenan, Wang, Shuaixing, Zhang, Youyi, Xiao, Han
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism AMPKα2 Animals Fibrosis Gene Expression Regulation - drug effects Kidney - drug effects Kidney - metabolism Kidney - pathology metformin Metformin - pharmacology Mice Mice, Inbred C57BL Phosphorylation - drug effects renal fibrosis Signal Transduction - drug effects Smad3 Protein - metabolism TGFβ1 Transforming Growth Factor beta1 - biosynthesis Transforming Growth Factor beta1 - metabolism Ureteral Obstruction - complications
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