Segmental colonic dilation is associated with premature termination of high‐amplitude propagating contractions in children with intractable functional constipation
Background Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC. Methods We performed a retrospective study on 30 children with intractable FC (acco...
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| Veröffentlicht in: | Neurogastroenterology and motility 2017-10, Vol.29 (10), p.1-9 |
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| creator | Koppen, I. J. N. Thompson, B. P. Ambeba, E. J. Lane, V. A. Bates, D. G. Minneci, P. C. Deans, K. J. Levitt, M. A. Wood, R. J. Benninga, M. A. Di Lorenzo, C. Yacob, D. |
| description | Background
Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC.
Methods
We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12‐month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure. Moreover, the distance between the lateral margins of the pedicles of vertebra L2 was measured to provide a ratio (colonic diameter or length/distance between the lateral margins; “standardized colon size” [SCS]). All manometry recordings were visually inspected for the presence of high‐amplitude propagating contractions (HAPCs); a parameter for colonic motility integrity. The intracolonic location of the manometry catheter sensors was assessed using an abdominal X‐ray.
Key Results
Colonic segments with HAPCs had a significantly smaller median diameter than colonic segments without HAPCs (4.08 cm vs 5.48 cm, P |
| doi_str_mv | 10.1111/nmo.13110 |
| format | Article |
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Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC.
Methods
We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12‐month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure. Moreover, the distance between the lateral margins of the pedicles of vertebra L2 was measured to provide a ratio (colonic diameter or length/distance between the lateral margins; “standardized colon size” [SCS]). All manometry recordings were visually inspected for the presence of high‐amplitude propagating contractions (HAPCs); a parameter for colonic motility integrity. The intracolonic location of the manometry catheter sensors was assessed using an abdominal X‐ray.
Key Results
Colonic segments with HAPCs had a significantly smaller median diameter than colonic segments without HAPCs (4.08 cm vs 5.48 cm, P<.001; SCS 1.14 vs 1.66, P=.001). Children with prematurely terminating HAPCs had significantly larger SCS ratios for colonic diameter than children with fully propagating HAPCs (P=.008). SCS ratios for the length of the rectosigmoid and the descending colon and the SCS ratio for sigmoid colon diameter were significantly larger in children with FC compared to a previously described normative population (P<.0001, P<.0001 and P=.0007 respectively).
Conclusions & Inferences
Segmental colonic dilation was associated with prematurely terminating HAPCs and may be a useful indicator of colonic dysmotility.
Colonic dilation is often encountered in children with severe functional constipation. In this study, segmental colonic dilation was associated with prematurely terminating high‐amplitude propagating contractions and may therefore be a useful indicator of colonic dysmotility.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.13110</identifier><identifier>PMID: 28524640</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Child ; Children ; Colon ; Colon - pathology ; Colon - physiopathology ; Constipation ; Constipation - pathology ; Constipation - physiopathology ; contrast enema ; Dilatation, Pathologic - pathology ; Dilatation, Pathologic - physiopathology ; dilation ; elongation ; Female ; Gastrointestinal Motility - physiology ; Humans ; Male ; Manometry ; Muscle Contraction - physiology ; Muscle, Smooth - physiopathology ; Retrospective Studies ; Spine ; Spleen ; Vertebrae</subject><ispartof>Neurogastroenterology and motility, 2017-10, Vol.29 (10), p.1-9</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-d6fb532a54b7ed70754fde5f0a8b1e2165818fdf687186d773b493cf66c13a143</citedby><cites>FETCH-LOGICAL-c3530-d6fb532a54b7ed70754fde5f0a8b1e2165818fdf687186d773b493cf66c13a143</cites><orcidid>0000-0002-1856-0968</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.13110$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.13110$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28524640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koppen, I. J. N.</creatorcontrib><creatorcontrib>Thompson, B. P.</creatorcontrib><creatorcontrib>Ambeba, E. J.</creatorcontrib><creatorcontrib>Lane, V. A.</creatorcontrib><creatorcontrib>Bates, D. G.</creatorcontrib><creatorcontrib>Minneci, P. C.</creatorcontrib><creatorcontrib>Deans, K. J.</creatorcontrib><creatorcontrib>Levitt, M. A.</creatorcontrib><creatorcontrib>Wood, R. J.</creatorcontrib><creatorcontrib>Benninga, M. A.</creatorcontrib><creatorcontrib>Di Lorenzo, C.</creatorcontrib><creatorcontrib>Yacob, D.</creatorcontrib><title>Segmental colonic dilation is associated with premature termination of high‐amplitude propagating contractions in children with intractable functional constipation</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC.
Methods
We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12‐month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure. Moreover, the distance between the lateral margins of the pedicles of vertebra L2 was measured to provide a ratio (colonic diameter or length/distance between the lateral margins; “standardized colon size” [SCS]). All manometry recordings were visually inspected for the presence of high‐amplitude propagating contractions (HAPCs); a parameter for colonic motility integrity. The intracolonic location of the manometry catheter sensors was assessed using an abdominal X‐ray.
Key Results
Colonic segments with HAPCs had a significantly smaller median diameter than colonic segments without HAPCs (4.08 cm vs 5.48 cm, P<.001; SCS 1.14 vs 1.66, P=.001). Children with prematurely terminating HAPCs had significantly larger SCS ratios for colonic diameter than children with fully propagating HAPCs (P=.008). SCS ratios for the length of the rectosigmoid and the descending colon and the SCS ratio for sigmoid colon diameter were significantly larger in children with FC compared to a previously described normative population (P<.0001, P<.0001 and P=.0007 respectively).
Conclusions & Inferences
Segmental colonic dilation was associated with prematurely terminating HAPCs and may be a useful indicator of colonic dysmotility.
Colonic dilation is often encountered in children with severe functional constipation. In this study, segmental colonic dilation was associated with prematurely terminating high‐amplitude propagating contractions and may therefore be a useful indicator of colonic dysmotility.</description><subject>Adolescent</subject><subject>Child</subject><subject>Children</subject><subject>Colon</subject><subject>Colon - pathology</subject><subject>Colon - physiopathology</subject><subject>Constipation</subject><subject>Constipation - pathology</subject><subject>Constipation - physiopathology</subject><subject>contrast enema</subject><subject>Dilatation, Pathologic - pathology</subject><subject>Dilatation, Pathologic - physiopathology</subject><subject>dilation</subject><subject>elongation</subject><subject>Female</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Manometry</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth - physiopathology</subject><subject>Retrospective Studies</subject><subject>Spine</subject><subject>Spleen</subject><subject>Vertebrae</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFuFSEUhonR2Fpd-AKGxI0upoVhYLhL07RqUu1CXU8YONxLw8AITJrufIS-hC_mk8i9U12YyIaTnC8ff_gReknJKa3nLEzxlDJKySN0TJngTbuR7eP9zElDNy0_Qs9yviGEiLYTT9FRK3kdOnKMfn6B7QShKI919DE4jY3zqrgYsMtY5Ry1UwUMvnVlh-cEkypLAlwgTS6sYLR457a7Xz_u1TR7VxYDlYyz2tZ92FZzKEnpPZuxC1jvnDcJwup061KNHrBdwgE7xAm5uPnwwnP0xCqf4cXDfYK-XV58Pf_QXF2__3j-7qrRjDPSGGFHzlrFu7EH05Oed9YAt0TJkUJLBZdUWmOF7KkUpu_Z2G2YtkJoyhTt2Al6s3pr-u8L5DJMLmvwXgWISx7ohhDJJGGyoq__QW_ikmrwPcV6Vr-Y00q9XSmdYs4J7DAnN6l0N1Ay7LsbanfDobvKvnowLuME5i_5p6wKnK3ArfNw93_T8PnT9ar8DapgqHo</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Koppen, I. J. N.</creator><creator>Thompson, B. P.</creator><creator>Ambeba, E. J.</creator><creator>Lane, V. A.</creator><creator>Bates, D. G.</creator><creator>Minneci, P. C.</creator><creator>Deans, K. J.</creator><creator>Levitt, M. A.</creator><creator>Wood, R. J.</creator><creator>Benninga, M. A.</creator><creator>Di Lorenzo, C.</creator><creator>Yacob, D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1856-0968</orcidid></search><sort><creationdate>201710</creationdate><title>Segmental colonic dilation is associated with premature termination of high‐amplitude propagating contractions in children with intractable functional constipation</title><author>Koppen, I. J. N. ; Thompson, B. P. ; Ambeba, E. J. ; Lane, V. A. ; Bates, D. G. ; Minneci, P. C. ; Deans, K. J. ; Levitt, M. A. ; Wood, R. J. ; Benninga, M. A. ; Di Lorenzo, C. ; Yacob, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-d6fb532a54b7ed70754fde5f0a8b1e2165818fdf687186d773b493cf66c13a143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Children</topic><topic>Colon</topic><topic>Colon - pathology</topic><topic>Colon - physiopathology</topic><topic>Constipation</topic><topic>Constipation - pathology</topic><topic>Constipation - physiopathology</topic><topic>contrast enema</topic><topic>Dilatation, Pathologic - pathology</topic><topic>Dilatation, Pathologic - physiopathology</topic><topic>dilation</topic><topic>elongation</topic><topic>Female</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Manometry</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth - physiopathology</topic><topic>Retrospective Studies</topic><topic>Spine</topic><topic>Spleen</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koppen, I. J. N.</creatorcontrib><creatorcontrib>Thompson, B. P.</creatorcontrib><creatorcontrib>Ambeba, E. J.</creatorcontrib><creatorcontrib>Lane, V. A.</creatorcontrib><creatorcontrib>Bates, D. G.</creatorcontrib><creatorcontrib>Minneci, P. C.</creatorcontrib><creatorcontrib>Deans, K. J.</creatorcontrib><creatorcontrib>Levitt, M. A.</creatorcontrib><creatorcontrib>Wood, R. J.</creatorcontrib><creatorcontrib>Benninga, M. A.</creatorcontrib><creatorcontrib>Di Lorenzo, C.</creatorcontrib><creatorcontrib>Yacob, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koppen, I. J. N.</au><au>Thompson, B. P.</au><au>Ambeba, E. J.</au><au>Lane, V. A.</au><au>Bates, D. G.</au><au>Minneci, P. C.</au><au>Deans, K. J.</au><au>Levitt, M. A.</au><au>Wood, R. J.</au><au>Benninga, M. A.</au><au>Di Lorenzo, C.</au><au>Yacob, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Segmental colonic dilation is associated with premature termination of high‐amplitude propagating contractions in children with intractable functional constipation</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2017-10</date><risdate>2017</risdate><volume>29</volume><issue>10</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC.
Methods
We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12‐month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure. Moreover, the distance between the lateral margins of the pedicles of vertebra L2 was measured to provide a ratio (colonic diameter or length/distance between the lateral margins; “standardized colon size” [SCS]). All manometry recordings were visually inspected for the presence of high‐amplitude propagating contractions (HAPCs); a parameter for colonic motility integrity. The intracolonic location of the manometry catheter sensors was assessed using an abdominal X‐ray.
Key Results
Colonic segments with HAPCs had a significantly smaller median diameter than colonic segments without HAPCs (4.08 cm vs 5.48 cm, P<.001; SCS 1.14 vs 1.66, P=.001). Children with prematurely terminating HAPCs had significantly larger SCS ratios for colonic diameter than children with fully propagating HAPCs (P=.008). SCS ratios for the length of the rectosigmoid and the descending colon and the SCS ratio for sigmoid colon diameter were significantly larger in children with FC compared to a previously described normative population (P<.0001, P<.0001 and P=.0007 respectively).
Conclusions & Inferences
Segmental colonic dilation was associated with prematurely terminating HAPCs and may be a useful indicator of colonic dysmotility.
Colonic dilation is often encountered in children with severe functional constipation. In this study, segmental colonic dilation was associated with prematurely terminating high‐amplitude propagating contractions and may therefore be a useful indicator of colonic dysmotility.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28524640</pmid><doi>10.1111/nmo.13110</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1856-0968</orcidid></addata></record> |
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| subjects | Adolescent Child Children Colon Colon - pathology Colon - physiopathology Constipation Constipation - pathology Constipation - physiopathology contrast enema Dilatation, Pathologic - pathology Dilatation, Pathologic - physiopathology dilation elongation Female Gastrointestinal Motility - physiology Humans Male Manometry Muscle Contraction - physiology Muscle, Smooth - physiopathology Retrospective Studies Spine Spleen Vertebrae |
| title | Segmental colonic dilation is associated with premature termination of high‐amplitude propagating contractions in children with intractable functional constipation |
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