Medroxyprogesterone acetate drives M2 macrophage differentiation toward a phenotype of decidual macrophage

M1 macrophage differentiation plays a crucial role in enhanced inflammation during pregnancy, which may lead to pregnancy complications. Therefore, modulation of macrophage differentiation toward the M2 phenotype is desirable to ensure a successful pregnancy. Medroxyprogesterone acetate (MPA) is a p...

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Veröffentlicht in:	Molecular and cellular endocrinology 2017-09, Vol.452, p.74-83
Hauptverfasser:	Tsai, Yung-Chieh, Tseng, Joseph T., Wang, Chia-Yih, Su, Mei-Tsz, Huang, Jyun-Yuan, Kuo, Pao-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Butadienes - pharmacology Cell Differentiation - drug effects Cytokines - metabolism Decidua - immunology Differentiation Endometritis - immunology Endometritis - pathology Enzyme Inhibitors - pharmacology Female Hormone Antagonists - pharmacology Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Macrophage Macrophages - cytology Macrophages - drug effects Medroxyprogesterone acetate Medroxyprogesterone Acetate - pharmacology Mifepristone - pharmacology Monocytes - cytology Monocytes - drug effects Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitriles - pharmacology Pregnancy Primary Cell Culture Stromal Cells - metabolism Tetradecanoylphorbol Acetate - pharmacology THP-1 Cells Trophoblasts - metabolism
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