A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein
Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-tr...
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| Veröffentlicht in: | Polish Journal of Veterinary Sciences 2017-03, Vol.20 (1), p.189-201 |
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| container_title | Polish Journal of Veterinary Sciences |
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| creator | Shahid, M Manchi, G Slunsky, P Naseer, O Fatima, A Leo, B Raila, J |
| description | Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases. This review deliberates our current findings of how the components of ECM change at the molecular level during disease progression in canine OA. |
| doi_str_mv | 10.1515/pjvs-2017-0024 |
| format | Article |
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| ispartof | Polish Journal of Veterinary Sciences, 2017-03, Vol.20 (1), p.189-201 |
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| subjects | Animals Arthritis Biomarkers Collagen Disease Dog Diseases - metabolism Dogs Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fluids Gene expression Gene Expression Regulation Knee NMR Nuclear magnetic resonance Osteoarthritis - metabolism Osteoarthritis - veterinary Proteins Proteoglycans Proteoglycans - genetics Proteoglycans - metabolism Urine Veterinary medicine |
| title | A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein |
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