Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA

Ribosome frameshifting during translation of bacterial dnaX can proceed via different routes, generating a variety of distinct polypeptides. Using kinetic experiments, we show that –1 frameshifting predominantly occurs during translocation of two tRNAs bound to the slippery sequence codons. This pat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell 2017-05, Vol.66 (4), p.558-567.e4
Hauptverfasser:	Caliskan, Neva, Wohlgemuth, Ingo, Korniy, Natalia, Pearson, Michael, Peske, Frank, Rodnina, Marina V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - biosynthesis Bacterial Proteins - genetics DNA Polymerase III - biosynthesis DNA Polymerase III - genetics dnaX Escherichia coli - enzymology Escherichia coli - genetics Frameshifting, Ribosomal Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Kinetics Mutation Nucleic Acid Conformation programmed ribosome frameshifting protein synthesis recoding RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Transfer, Amino Acyl - chemistry RNA, Transfer, Amino Acyl - genetics RNA, Transfer, Amino Acyl - metabolism Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship Tandem Mass Spectrometry translation pausing translation regulation tRNA abundance
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!